Functional Metabolomics Lab
- Reposted by Functional Metabolomics LabPreprint from our lab and @func-metabo-lab.bsky.social: In synthetic nasal communities a single Corynebacterium propinquum strain can exclude Staphylococcus aureus through nutrient competition. www.biorxiv.org/content/10.6...
- New paper from our team: Led by @nike-wagner.bsky.social, we just published our findings on how the metabolite class of pteridines binds to the previously cryptic CutA protein. We used our native metabolomics approach to identify pteridines as ligands of CutA. www.pnas.org/doi/10.1073/...
- Our data show that CutA binds copper more strongly in the presence of pteridines, suggesting that these metabolites act as co-factors that modulate copper binding and redox homeostasis.
- A huge thank you to Nike and the Forchhammer Lab and to Khaled Selim and all co-authors, especially our Natural-Product-Partner-in-Crime Chambers Hughes for solving the structure of 2’-deoxyxanthopterin B2, and Karoline Steuer-Lodd and the Ansel Hsiao lab for generating the mutants.
- We are super excited that our new paper on microfluidic-based LC-MS/MS fractionation in combination with bioluminescence bioreporters readouts, for compound-resolved bioactivity metabolomics, was just published: pubs.acs.org/doi/10.1021/...
- Its great to see the project in completion after almost four years ago, when Albert Hernandez, a mechanical engineer from UCSD, joined us in Tübingen, and started building the microspotter.
- Combining the new tool with the bioluminescent bioreporter strains from Heike Brötz-Oesterhelt and her students Julian Schubert and Leonard Boldt was a key element to achieve the high sensitivity of the bioactivity assays needed for microfractions.
- Reposted by Functional Metabolomics LabNew paper from the group. Together with Chambers Hughes, Giovanni Vitale and our amazing collaborators, we developed a multiplexed chemical metabolomics workflow to assign functional groups in non-targeted LC-MS/MS data: www.nature.com/articles/s41... Behind the paper story: go.nature.com/45ljV4d
- We are super excited to start a new project with support from the Simons Foundation. We will leverage our metabolomics tools and SynCom models to study how microbes shape the production, transformation, and fate of marine DOM. Thanks so much @simonsfoundation.org for making this possible!
- Congratulations to our six new 2025 Simons Early Career Investigators in Aquatic Microbial Ecology and Evolution! See full list: www.simonsfoundation.org/2025/07/01/a... #science @systemsecology.bsky.social @daniel-petras.bsky.social @kendraturkkubo.bsky.social
- We are pretty stoked that our paper on chemical shifts in kelp forests in the Gulf of Maine made it onto the front cover of @science.org Big congratulations to Shane Farrell and everybody involved! ✌️✌️✌️
- Kelp forests on the coast of Maine are in decline owing to rapid ocean warming and are being replaced by turf algae, which alter the ecosystem’s chemistry, hindering the recovery of kelp forests. Learn more in this week's issue of Science: scim.ag/4dwzl8j
- If you want to read more about how the changing reef exo-metabolome, driven by invasive red algae, affects kelp survival, you can find the paper here: www.science.org/doi/10.1126/...
- Reposted by Functional Metabolomics LabExciting invited talk by Daniel Petras @daniel-petras.bsky.social Functional #Metabolomics Approaches for Understanding Microbial Community Dynamics at the Molecular Level. #ICTC13 @func-metabo-lab.bsky.social
- Reposted by Functional Metabolomics LabAnother success story of native MS. Pteridines, found also in #cyanobacteria, bind to cutA, possibly bridging copper homeostasis and cellular redox regulation. doi.org/10.1101/2025... More about functional metabolomics at #ICTC13 from @daniel-petras.bsky.social (Invited speaker).
