- New paper from our team: Led by @nike-wagner.bsky.social, we just published our findings on how the metabolite class of pteridines binds to the previously cryptic CutA protein. We used our native metabolomics approach to identify pteridines as ligands of CutA. www.pnas.org/doi/10.1073/...Nov 27, 2025 02:16
- Our data show that CutA binds copper more strongly in the presence of pteridines, suggesting that these metabolites act as co-factors that modulate copper binding and redox homeostasis.
- A huge thank you to Nike and the Forchhammer Lab and to Khaled Selim and all co-authors, especially our Natural-Product-Partner-in-Crime Chambers Hughes for solving the structure of 2’-deoxyxanthopterin B2, and Karoline Steuer-Lodd and the Ansel Hsiao lab for generating the mutants.
- Great work Daniel!
