Iris Irby
PhD Candidate in the Brown Lab at Georgia Tech | mobile genetic element enthusiast 🧬 | NSF Graduate Research Fellow
- Reposted by Iris IrbyPhage-host interactions have a role shaping microbial ecosystems, but what happens in #microgravity? Experiments aboard the #ISS reveal distinct evolutionary adaptations in T7 bacteriophage & #Ecoli, revealing #phage variants effective against resistant pathogens @plosbiology.org 🧪 plos.io/3LtKOfs
- Reposted by Iris IrbyOur new review highlights that ants, cockroaches, and flies carry antimicrobial-resistant bacteria and fungi in hospitals. Better pest management is key to infection prevention. #ASHEJournal #microsky www.cambridge.org/core/journal...
- Reposted by Iris IrbyThe distinction between virulent & temperate phages gets fuzzier if one can find so many virulent phages in the sequences of bacterial genomes coming from standard lab "pure" cultures. Check Peter's thread on our work and the N&V by Carson & Hynes: doi.org/10.1038/s415... #phagesky #microsky
- [1/3] Is your favorite bacterial isolate hiding a surprise lytic virus with a VERY different lifestyle? Finally I can proudly say that our paper on persistent phages is out in Nature Microbiology. rdcu.be/eWJEp. Well done @peterdoug.bsky.social
- Reposted by Iris IrbyThe final form of my 2nd postdoc paper with the Bassler Lab! Turns out our favorite quorum-sensing phage isn’t a one-off, but rather a member of a globally dispersed family of phages that sense a universal autoinducer. #phagesky #microsky journals.asm.org/doi/10.1128/...
- Reposted by Iris IrbyVery happy to see this piece out in @plosbiology.org, on the bacterial immune systems and microbial communities. It was a great team effort with Rafael Custodio, @brockhurstlab.bsky.social , @brownlab.bsky.social, and Edze Westra! 🦠🧫 #phagesky #mevosky journals.plos.org/plosbiology/...
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- Reposted by Iris IrbyPhages evolve fast, or do they? In oysters, some stay identical for years. With >1,200 phages & 600 Vibrio genomes, we reveal long-term stability and new mobile elements. Proud of this collaborative work across our teams (Roscoff-UdeM and @epcrocha.bsky.social www.biorxiv.org/cgi/content/...
- Reposted by Iris IrbyNew pre-print www.biorxiv.org/content/10.1... Plasmid-dependent phage (PDPs) are ubiquitous, but the selective pressures that they impose on plasmids are not well understood. Project led by Daniel Cazares in collaboration with @brockhurstlab.bsky.social! #phagesky#microsky
- Reposted by Iris IrbyNew preprint! Ever wondered why only a fraction of genomes encode CRISPR immunity? 🧬 🦠 Turns out CRISPR is rarely beneficial against virulent phages, being most beneficial against those for which resistance mutations are rare! An epic effort by Rosanna Wright www.biorxiv.org/content/10.1...
- Reposted by Iris IrbyDYK most P. aeruginosa carry filamentous phage(s) that don't need to kill the cell to reproduce? We 👉🏻@nanamikubota.bsky.social show that these Pf phages can go ROGUE. "Filamentous cheater phages drive bacterial and phage populations to lower fitness" 🔗 authors.elsevier.com/c/1lt5I3QW8S...
- Reposted by Iris IrbyIf you ever find yourself needing evidence for ‘Plasmids are just as common in microbes without resistance genes,’ we’ve got you covered! Check our new paper, out today: www.microbiologyresearch.org/content/jour...
- Reposted by Iris IrbyStoked to finally have a preprint out for Phold, our tool that uses protein structural information to enhance phage genome annotation #phagesky 1/n www.biorxiv.org/content/10.1...
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- Reposted by Iris IrbyNew pre-print from my lab! Plasmids link antibiotic resistance and phage defense. E.coli plasmids are hotspots for both antibiotic resistance and phage defense. Phage therapy has the potential to accidentally select for antibiotic resistance!!! #microsky#AMR#phage www.biorxiv.org/content/10.1....
- Reposted by Iris IrbyAfter many years in the making, here is our host range #phage paper with #ecology, #evolution and #biocontrol perspectives published in Molecular Ecology! @phimresearch.bsky.social @inrae-pv.bsky.social #PVBMT #JulianGarneau onlinelibrary.wiley.com/doi/10.1111/... These are our key findings:
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- Reposted by Iris IrbyHere's our new broad review on the extended mobility of plasmids, about all mechanisms driving and limiting their transfer. From conjugation to conduction, phage-plasmids to hitchers, molecular to evolutionary dynamics, ecology to biotech. The state of affairs. 1/9 academic.oup.com/nar/article/...
- Reposted by Iris IrbyDo plasmids evolve faster 🐇, slower 🐢, or just like chromosomes 🧬? In our new paper, we tackled this question using theory, simulations, bioinformatics, and experiments! 👇 Check out all the details in Paula’s thread! Hint: 🐇 (most of the time)
- Reposted by Iris IrbyWe made structural predictions of representatives of each #PHROG from #phage genomes, and put the whole lot online. You can browse through montages or go to your favourite phrog directly and download its PDB. 💻🧬 #phagesky linsalrob.github.io/PHROG_struct...
- Reposted by Iris IrbyCurious about plasmid biology? Our latest paper is out now in Nature Communications! 🚨 doi.org/10.1038/s414... We analyzed thousands of diverse bacterial plasmids to shed light for the first time on a key aspect of plasmid biology: plasmid copy number. 1/7 👇
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- Reposted by Iris IrbyBig day for the Gurney lab, first paper from the lab is now published. @sczerwinski.bsky.social led this work and answered a simple question does phage steering work when other bacteria are around? Tldr: yes! journals.asm.org/doi/epub/10....
- Reposted by Iris IrbyOur new big review on Pseudomonas aeruginosa. Hope you enjoy reading it. www.nature.com/articles/s41...
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- Reposted by Iris IrbyDefence Systems are so hot right now 🔥 🔥 🔥 so check out our latest preprint to see how DSes contribute to niche adaptation, interact with each other, and drive accessory genome interactions in Pseudomonas aeruginosa 1/n www.biorxiv.org/content/10.1...
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- So excited to be able to introduce Mystique to the world! Had such a great time working with @ellinoralseth.bsky.social, @phagephan.bsky.social, and the rest of the team!
- Mystique is here! When I started my position at @cmdi.bsky.social there were no readily available phage against my A. baumannii focal strain. The solution? Finding my own phage ofc. Mystique is a broad host range Acinetobacter phage, and I'm thrilled to see this work out today #PhageSky 🧪🦠
- Reposted by Iris IrbyPreprint out! Bacteria w/ hyper-replicative filamentous phage lead to overnight emergence of cheater phages. Bacteria w/ both phages can outcompete wildtype, then rapidly lose phage via a phage Tragedy of the Commons @shellyscrib.bsky.social @vscooper.micropopbio.org www.biorxiv.org/content/10.1...
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- At #standupforscience Atlanta!
