Nisha Rafiq
Excellence Strategy Group Leader, University of Tübingen, Germany. nisharafiqlab.com
- Reposted by Nisha Rafiq🧪⚛️ Surface tension—driven by non-equilibrium currents not forces—in pattern formation leads to the same type of interface laws as in liquid foams: Plateau laws, von Neumann evolution; and a new emergent phenomenon: domain splitting akin to cell division. nature.com/articles/s4156…
- At ASCB this year in Philly? Will speak about MT lattice spacing in cells and neurons 🙂 See info below..
- Reposted by Nisha RafiqHow do cells recognize matrix topography? In this preprint we show that α5β1-integrin fibrillar adhesions rapidly form in response to topographic cues like electrospun nanofibers- no actomyosin contractility, focal adhesions or fibronectin secretion needed doi.org/10.1101/2025...
- Please join me for the upcoming talk in the neurocolloquium!
- 📢 Join us for the „IFIB Lecture“ in the Neurocolloquium on Nov 27 at 4.15pm: Melike Lakadamyali (Uni of Pennsylvania) will talk about "Super-resolution imaging of tau in physiology and pathology“, in Tübingen & in Zoom @melikel.bsky.social @nishamrafiq.bsky.social 👉 Zoom link tinyurl.com/54fs7rmc
- Listened to the talk by the first author at SfN and was pleasantly surprised to see so many synaptic proteins, including my all-time favorite: synaptojanin-1!
- Reposted by Nisha RafiqThrilled to share "in situ APEX activation" (iAPEX), a proximity labeling technology for subcellular #proteomics applied to primary #cilia. iAPEX uses an enzymatic cascade, in which a D-amino acid oxidase locally produces H2O2 to activate ascorbate peroxidase. www.nature.com/articles/s41...
- Reposted by Nisha RafiqIf you’re at #sfn25 you definitely don’t want to miss this nanosymposium on cilia, tomorrow from 1-4pm! Come learn about neuronal cilia, they do some pretty cool stuff!
- Synapses may get all the glory, but join us cilia-philes for our @sfn.org Nanosymposium to learn about the role of cilia in modulating brain activity, behavior, and development. Sunday November 16th 1-4pm SDCC Room 25A. Thrilled to chair with @konjikusicmia.bsky.social - we'll see you there!
- Reposted by Nisha Rafiq'Redefining dopaminergic synapses beyond the classical paradigm' Kenshiro Fujise, Jaya Mishra, Nasser Karmali & Nisha M. Rafiq @nishamrafiq.bsky.social www.cell.com/trends/neuro...
- what a beauty!!
- Lab’s first paper is out!! We show the first structures of #Asgard #chromatin by #cryo-EM 🧬❄️ Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
- Looking forward to speak here!
- Synapses may get all the glory, but join us cilia-philes for our @sfn.org Nanosymposium to learn about the role of cilia in modulating brain activity, behavior, and development. Sunday November 16th 1-4pm SDCC Room 25A. Thrilled to chair with @konjikusicmia.bsky.social - we'll see you there!
- Do you like following rules… but also breaking them? So does your dopaminergic synapse! 😎🧠 Our new Trends in Neurosciences review dives into the non-classical side of dopamine signaling, notably the tools reshaping how we see it (CLEM, cryo-CLEM, serial EM + more).
- See link here: www.cell.com/trends/neuro...
- what an animation!
- Happy to share the inaugural paper from the lab. We describe a molecular mechanism for the activation of outer dynein arm motors that power the vital motion of cilia. Open access link below: www.nature.com/articles/s41... Here's a cool animated summary
- Reposted by Nisha RafiqNew paper alert! I’m very excited to share our paper published in @embojournal.org! @pdc-lab.bsky.social @yaleneuro.bsky.social
- Reposted by Nisha Rafiq@anbangdai.bsky.social et al. @pdc-lab.bsky.social report the localization of BLTP2 in different human cell types & reveal binding partners that mediate its tethering to the PM & to PM-connected structures including certain #endosomes & #macropinosomes undergoing fusion rupress.org/jcb/article/...
- Reposted by Nisha RafiqVery happy that the first article from my postdoc work in the Tomancak lab is now published @PNAS! www.pnas.org/doi/10.1073/.... We studied the self-organization of actin in aggregates made from Hydra cells. Thread below (1/9)
- Cilia in the brain! Depiction on angular and orientation information across different parts of the mouse brain...
- Cilia in the #brain display region-dependent oscillations of length and orientation @PLOSBiology.org
- Reposted by Nisha RafiqDid you know that Bioimage Archive has a specific database for people to share AI-ready imaging datasets? I did not until @yanlanmao.bsky.social told me! Please deposit! If people regularly submitted, it would have a huge collective impact on bioimage analysis. www.ebi.ac.uk/bioimage-arc...
- Reposted by Nisha RafiqEU augments opportunities for scientists around the world to launch or re-launch their careers in Europe.
- Europe’s choice is clear. To put science at the heart of its economy. To become the home of scientific freedom and collaboration. And to welcome talent from all over the world. I’m glad to present the first elements of our Choose Europe Initiative. → europa.eu/!TTbWbJ
- Reposted by Nisha RafiqToday, FutureHouse is releasing the first dedicated AI Agents for Science, via our Platform. These agents are able to perform a wide variety of scientific tasks better than humans. With the platform, we are bringing these capabilities to the wider community. 1/2
- Reposted by Nisha RafiqA package of research papers from the MICrONS (Machine Intelligence from Cortical Networks) consortium in Nature and Nature Methods provides a detailed map of mouse brain cell structure and connections, offering insights into how they relate to activity in the mouse brain. 🧪
- Reposted by Nisha Rafiq[Not loaded yet]
- Eid Mubarak! May this special day bring peace, joy, and blessings to you and your loved ones. 😊
- Reposted by Nisha RafiqPost doc in Europe? 🇪🇺🔬💡 It’s open to anyone in the 🌍 Call open 9 April 25 marie-sklodowska-curie-actions.ec.europa.eu/actions/post...
- Reposted by Nisha RafiqConstrained roads to complex brains Neural development and brain circuit evolution converged in birds and mammals www.science.org/doi/10.1126/...
- Reposted by Nisha RafiqVery happy to share our last preprint where we investigated the vesicular organization of dopamine hub synapses with cryo-CLEM. It is a brain structure that emerges as an important regulator of striatal activity. Many thanks to David Perrais, Etienne Herzog and the lab of @fronzeslab.bsky.social !
