Lukas A. Basedow, PhD
Postdoc & Clinical Psychologist @unimarburg.bsky.social & @SFB-TRR-289.bsky.social
Coordinator of the German Addiction Association - ECR network.
Interested in placebo effects, drugs & clinical psychology. All views my own.
- Reposted by Lukas A. Basedow, PhDtldr: in past 25 years annual incidence of psychotic disorders increased by 60% in 14-20 year olds, in Ontario🇨🇦; rates stable or lower among 21 to 50 y/o A few possible factors: ⬆️parental age, ⬆️substance use, maternal/neonatal health, other stressors). 🧪🧠 #neuroskyence www.cmaj.ca/content/198/...
- Great analysis from an economical perspective on the issue of receiving psychotherapy when indicated!
- 🧵 New WP with @kaimiele.bsky.social. We document 2 unsettling patterns in mental health care: 1) despite universal coverage, few individuals with mental illness receive guideline-consistent treatment, and 2) the more severe the illness, the lower the treatment uptake & the longer the wait times. 1/n
- Reposted by Lukas A. Basedow, PhDFirst post of the year, new paper out today: we present possibly the biggest case of systematic Measurement Schmeasurement in tech use. It seems that most studies on gaming (videogame) addiction/disorder haven't measured gaming after all. This research took years, so long 🧵 doi.org/10.1098/rsos...
- Reposted by Lukas A. Basedow, PhDI've never experienced anything like this in my life, where people keep telling me that "we have to use AI or else we'll be left behind" but they don't actually tell me exactly what problem they are hoping to solve with the "AI" or how we would know it was useful. But we must use it! Apparently.
- Finally got around to reading this great paper. A really insightful argument for treating psychedelic-assisted therapy as psychotherapy!
- With Zalsupindole (see quoted skeet) and Bretisilocin (5F-MET; journals.sagepub.com/doi/10.1177/...) there are very exciting things happening in the psychedelic drug development world. 5F-MET especially might be well suited to psychedelic-assisted psychotherapy with a half life of 40-50 minutes!
- Big week for all you second-gen psychedelics and non-hallucinatory neuroplastogens fans! New results from Zalsupindole - promotes greater neuroplasticity than ketamine, psilocybin, or DMT, without any of the pesky psychedelic side (fun?) effects. pubs.acs.org/doi/abs/10.1...
- Reposted by Lukas A. Basedow, PhDAre you a journal editor in Psychology? There's a lot you can do to help support PCI Psych! PCI Psychology is a journal-independent peer review platform where journal editors like you evaluate and recommend preprints, that can then be published in PCI-friendly partner journals. 1/🧵 #PsychSciSky
- Reposted by Lukas A. Basedow, PhDSeeing lots of reactions to this compelling paper - showing VTA dopamine is linked to cue and outcome induced behavioral reactions: www.nature.com/articles/s41... I have some thoughts…
- Reposted by Lukas A. Basedow, PhDResults of the replication are in! Chocolate is more desirable than poop: Cohen's d_rm = 6.20, 95%CI [5.63, 6.78] N = 486, two single item 1-7 Likert scales of desirability. w/ @jamiecummins.bsky.social
- Make an effect size prediction! @jamiecummins.bsky.social and I are replicating Balcetis & Dunning's (2010) "chocolate is more desirable than poop" (Cohen's d = 4.52) Let us known in the replies what effect size you think we'll find. Details of the study in the thread below.
- Reposted by Lukas A. Basedow, PhDExcellent opportunity to pursue a PhD on dissociative states with @susannahpick.bsky.social and me at the IoPPN @kingsioppn.bsky.social Reach out to us with any questions
- Reposted by Lukas A. Basedow, PhDTotal wichtige Studie. Die Industrie ist hier nicht nur unglaubwürdig, sondern geradezu zynisch. In Schottland wurde der Mindestpreis, der sich dezidiert gegen den Konsum großer Mengen billigen Alkohols richtet, jahrelang von der Alkoholindustrie gerichtlich aufgehalten.
- Reposted by Lukas A. Basedow, PhDWe often hear from reviewers: "what about demand effects?" So we developed a method to eliminate them. Something weird happened during testing: We couldn’t detect demand effects in the first place! (1/8)
- Reposted by Lukas A. Basedow, PhDIt has often been suggested that psychotherapy works because patients expect it will work before they have even started treatment. But what if treatment expectations are an emergent phenomenon that develops in the course of psychotherapy and contributes to a successful outcome?
- Reposted by Lukas A. Basedow, PhD#Bewusstseinskultur #Rausch „Die Drogen langweilen uns mit ihrem Paradies” PDF-Volltext: rb.gy/h568tp
- Reposted by Lukas A. Basedow, PhDWhat can *genetic insensitivity to opioids* teach us about endogenous opioid function in humans? Fully funded position in Oslo (PhD student or postdoc) Interested in pain, mu/kappa opioids, behavioural genetics, RCTs, or related? Apply here: 2411.webcruiter.no/Main2/Recrui... Please RT for reach
- Reposted by Lukas A. Basedow, PhDAre interoception and mental health linked? Many assume so, with interoception even described as a psychiatric “p-factor.” But in our latest preprint, we were surprised to find little evidence for such a connection. www.medrxiv.org/content/10.1... 🧵 Thread with our reflections on the matter 👇
- Reposted by Lukas A. Basedow, PhD🍄 Our new living systematic review and meta-analysis on psilocybin for depression is out. Here's what we found and the open science infrastructure we built to support it 🧪🧵 www.medrxiv.org/content/10.1...
- Reposted by Lukas A. Basedow, PhD1. I need to recover this thread from X about a review on lithium in tap-water and suicide. It shows that papers aren't retracted despite being total nonsense
- Reposted by Lukas A. Basedow, PhD📣 Noch 2 Tage bis zum Bewerbungsschluss! Bitte teilen – wir freuen uns auf die Bewerbungen! 🤩
- 🚀 Unsere Arbeitsgruppe an der TU Dresden sucht Verstärkung! Wir bieten eine Postdoc- oder WiMi-Stelle (50%, E13 TV-L) ab 15.09.2025 an der Professur für Klinische Kinder- und Jugendpsychologie. Bewirb dich bis 7.8. und werde Teil unseres Teams! 👇👇👇 tu-dresden.de/mn/psycholog...
- Reposted by Lukas A. Basedow, PhDBit of a quiet landmark this study. Offers significant evidence to suggest non hallucinogenic psychedelic analogs could be effective as antidepressants. Amazing stuff.
- Reposted by Lukas A. Basedow, PhDHuge congratulations to our two CRC members @labasedow.bsky.social and Marcel Wilhelm from @unimarburg.bsky.social for winning two out of four science slam prizes! 🥳🤯 Of course we also congratulate @ldruart.bsky.social and Pavel Goldstein for the other two awards - all super deserved! 🤩
- Really happy to be able to present my Poster regarding placebo-induced psychedelic effects at #SIPSplacebo2025 Funded by the @sfb-trr-289.bsky.social
- Really happy to have participated again. Always a fun challenge! @sfb-trr-289.bsky.social @sipsplacebo.bsky.social #SIPSplacebo2025
- Next up, @labasedow.bsky.social from @unimarburg.bsky.social tells us about fake drugs and real highs! 🫠 But can we really get high from a placebo drug? What are the mechanisms?
- Reposted by Lukas A. Basedow, PhDHuge thanks to Lene Vase for highlighting both our recent placebo meta-analysis and the patient advisory board ❤️ The meta-analysis: www.biorxiv.org/content/10.1... The patient advisory board: treatment-expectation.de/projekte-peo... @sipsplacebo.bsky.social #SIPSplacebo2025
- Reposted by Lukas A. Basedow, PhDGlad to see this paper out finally. Well done @trpwolff.bsky.social for driving it! I think this idea has potential for significant impact in psychedelic drug development. /1 🧵 👇 📄 doi.org/10.1177/2050...
- Reposted by Lukas A. Basedow, PhD✨ Job opportunity! ✨ We're currently seeking a Research Associate in Psychology for a new project led by @fieldmatt.bsky.social which will use machine learning to develop a better understanding of why many people drop out of treatment for gambling problems. More project info at: bit.ly/45WEyVb
- Reposted by Lukas A. Basedow, PhDPCI Psychology is here!! 🎉🥳 After over a year of hard work by so many people, we are thrilled to announce that we are open for submissions! Join us in making publishing more efficient, equitable, and open: psych.peercommunityin.org #PsychSciSky #scipub
- Peer Community in Psychology: A platform for peer review of preprints across psychology: osf.io/m456e
- Reposted by Lukas A. Basedow, PhDAn der @rptu.bsky.social wird eine neue W2-Professur "Klinische Psychologie und Psychopathologie" geschaffen 🎉 Wir freuen uns über zahlreiche Bewerbungen und stehen auf dem #dpk25 bei Fragen gerne zur Verfügung! jobs.rptu.de/jobposting/0...
- Reposted by Lukas A. Basedow, PhDGerne weiterteilen und geeignete Kandidat:innen darauf aufmerksam machen! Neben Verfahrensoffenheit ist auch offen, ob Schwerpunkt auf Kinder & Jugendliche oder Erwachsene - oder eben über die Lebensspanne
- An der @rptu.bsky.social wird eine neue W2-Professur "Klinische Psychologie und Psychopathologie" geschaffen 🎉 Wir freuen uns über zahlreiche Bewerbungen und stehen auf dem #dpk25 bei Fragen gerne zur Verfügung! jobs.rptu.de/jobposting/0...
- Really proud that this paper got published: www.sciencedirect.com/science/arti... While I was only involved peripherally in the final publication, this paper is the result of a project I started during my master thesis 8 years ago! It's great to see continuous collaboration result in a cool paper.
- Reposted by Lukas A. Basedow, PhD“We argue that high-quality collective outcomes are endangered not only by self-interested individual defectors, but by ‘cartels’ of mutually satisfied mediocrities.” 👀 I’ve often referred to Gambetta’s book in the context of academic dysfunction. Very excited to discover more relevant work!
- Great to see a psychedelic null result published in JAMA Psychiatry! "[...], repeated low-dose LSD administration was safe in an outpatient setting, but it was not more efficacious than placebo in reducing ADHD symptoms." (Strong Placebo response as well!) jamanetwork.com/journals/jam...
- Reposted by Lukas A. Basedow, PhDNew blog post! In which I explain the issue with mediation analysis and sketch out one way to deal with the underlying causal inference problem -- in just a bit over 1,000 words! If you have never found the time to read up on this, now is your chance. www.the100.ci/2025/03/20/r...
- Reposted by Lukas A. Basedow, PhD🔥Frisch gedruckt im PTJ🔥: @tkaiser.science , Rafaële Huntjens und ich haben in dem Artikel gängige (Fehl-)Annahmen in der klinischen Praxis im Zusammenhang mit der Dissoziativen Identitätsstörung (#DIS) aus Sicht der Wissenschaft näher beleuchtet. Ein Thread 🧵: 1/
- Reposted by Lukas A. Basedow, PhDOur first qualitative study on the Flotatation experience as Preprint: "Silence, darkness, and gravity: A qualitative analysis of individual experiences during Floatation-REST". By Kristin Schiffer, Eric Pfeifer, Christine Stolterfoth, and Marc Wittmann osf.io/preprints/ps...
- Reposted by Lukas A. Basedow, PhDHi everyone, if you are interested in #psychedelic-assisted therapy, we just published a new study: www.sciencedirect.com/science/arti.... Congratulations to Dr. Nathalie Rieser, who has done a terrific job spearheading this project.
- Reposted by Lukas A. Basedow, PhDI waited for this paper by @robinawester.bsky.social, @ehrenthal-lab.bsky.social et al. to appear and finally, it's there. A mixed-methods survey on how German psychotherapists engage in personalized treatment selection. The results are interesting.
- Reposted by Lukas A. Basedow, PhDIt's out! Elated to share our latest work. I am incredibly proud of Ashley and the entire team. This study really brings together the best of everything we've been doing, and is the culimination of our research so far. It has everything - psychophysics, modelling, drug manipulation of intero!
- 1/ We can measure interoception in many aspects, but can we actually manipulate it? I’m excited to share our new study, which shows that blockade of peripheral beta-adrenergic pathways improves cardiac and respiratory interoception in unique ways! 🧵 www.biorxiv.org/content/10.1...
- Reposted by Lukas A. Basedow, PhD🚨📃New Wassum Lab Paper📃🚨 Out today, @jackiegio.bsky.social discovered brain pathways that support agency and habit and how chronic stress disrupts them to rob of us our agency and cause us to form rigid habits 🧵👇 www.nature.com/articles/s41... Free full text: rdcu.be/eaxEv
- Reposted by Lukas A. Basedow, PhD🏰 PhD position on computational modelling | collective dynamics | cultural evolution 🏰 Get in touch with any questions you might have and join me in beautiful Marburg! stellenangebote.uni-marburg.de/jobposting/c... (Deutsch) stellenangebote.uni-marburg.de/jobposting/3... (English)
- My former PhD @dominikdeffner.bsky.social is now a professor and is looking for a PhD student. Know someone who would fit? stellenangebote.uni-marburg.de/jobposting/3...
- Reposted by Lukas A. Basedow, PhDScientific publishing cannot be free but an annual $2.5 billion seems excessive to me
- Reposted by Lukas A. Basedow, PhD"...ergibt sich [...] im Durchschnitt ein personeller Mehrbedarf im ärztlichen und pflegerischen Bereich von 103 Prozent..." Ach... #Psychotherapie #Psychiatrie www.aerzteblatt.de/archiv/24254...
- Reposted by Lukas A. Basedow, PhD"Missing outcome data in randomised clinical trials of psychological interventions: a review of published trial reports in major psychiatry journals"
- Reposted by Lukas A. Basedow, PhDNew results for a new year! “Linking neural population formatting to function” describes our modern take on an old question: how can we understand the contribution of a brain area to behavior? www.biorxiv.org/content/10.1... 🧠👩🏻🔬🧪🧵 #neuroskyence 1/
- Reposted by Lukas A. Basedow, PhDHow did people get significant positive effects for so long? Small groups (N<10 is typical), p-hacking, harking. How much time, money have we wasted on that technique? (I was part of the problem) I hope people starting Focused Ultrasound are taking notes (but I see the same mistakes being done)
- Reposted by Lukas A. Basedow, PhDWow! I think this is one of the best (and most beautiful) demonstrations I've seen of the exquisite structure and specificity of neural circuits!
- I used VVD Viewer for this #FluorescenceFriday video: 141 volumes from the #HHMIJanelia FlyLight Split-GAL4 #Drosophila driver collection. The animation comes from a high-level description processed by neuVid. Such a rapid tour of the data has questionable scientific value, but it's fun to watch!
- Reposted by Lukas A. Basedow, PhD"Several scientists I spoke to whose work appears in the book ['The Body Keeps the Score'] say van der Kolk mischaracterizes their research and steers survivors away from treatments that might help them." @araldob.bsky.social, @tflangkaas.bsky.social
- Looks like the Body Keeps the Score may have tried to rig the game.👇 www.motherjones.com/media/2024/1...
- Reposted by Lukas A. Basedow, PhDThe proposition facing patients for most drug trials isn't "you will be given placebo, or some miracle drug" It's "you will be given the standard of care you would receive if not enrolled on the trial plus a placebo, or that standard of care plus a new drug that may or may not be effective"
- Reposted by Lukas A. Basedow, PhDI agree w/ the problem description, but I'm skeptical of the proposed solution. Yes, the efficacy of treatment is to some extent substantially overestimated (due to publication bias, risk of bias etc.). However, the evidence for the effectiveness of universal prevention strategies is *even worse*.
- Reposted by Lukas A. Basedow, PhDGemütlich im Mittelbau #einkuscheln?! Ihr wisst: Ich habe #IchBinHanna gestern im Wissenschaftsausschuss des NRW-Landtags vertreten. Was ich da alles gesagt hab? 1 🧵! Da ich vermute, dass Euch das besonders interessiert, fange ich mal mit meiner Reaktion auf das Einkuscheln an. (1/8)
- Reposted by Lukas A. Basedow, PhDWie wirksam ist Esketamin? Für KollegInnen aus dem deutschsprachigen Raum habe ich eine Zusammenfassung der Wirksamkeitsstudien gemacht. docs.google.com/document/d/1...
- Reposted by Lukas A. Basedow, PhDthat was supposed to say "expel"...
- Reposted by Lukas A. Basedow, PhD🚨Out in Science🚨 Megastudy testing 25 treatments to reduce antidemocratic attitudes and partisan animosity a) Many treatments reduce partisan animosity b) Some treatments reduce support for undemocratic practices/political violence c) a & b are pretty unrelated www.science.org/doi/10.1126/...
- Reposted by Lukas A. Basedow, PhD🚨We have another open PhD position, located within the #CRC289 about affective expectation effects. Please share #neuroscience
- Reposted by Lukas A. Basedow, PhDGreat. I am ready to teach statistics!
- Reposted by Lukas A. Basedow, PhDWe know the drivers of research waste in academia are ⚠️Pressure to maximize papers and PhD students ⚠️Endless demands on time due to poor management ⚠️Stakeholders don't insist on robust quality systems to underpin mission critical work Solutions that don't address these are pointless.
- Reposted by Lukas A. Basedow, PhD
I'll say it again: if you faked Westerns (or any images) you probably faked a ton of other shit. Image data aren't the problem, it's just where we catch people. www.science.org/content/arti...
