Pasero lab
- Reposted by Pasero labIn this new paper we find that Tel1 kinase (yeast ATM) targets D/E-S/T motifs… more prevalent than S/T-Q! Mec1 (yeast ATR) can’t target D/E-S/T, so we think D/E-S/T targeting allows Tel1 functional specialization. A mutation in Tel1 makes it only target S/T-Q… and cells become CPT sensitive.
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- Reposted by Pasero labCongratulations to Jenna Whalen on her Nature Cancer paper out today-a distinct take on nicks and their toxicity! rdcu.be/d60Td
