Thomas Gorochowski
Synthetic biologist, programmer of cells, and lover of all things visual. Wakes up in the morning to learn some of natures secrets and do a spot of fly fishing.
- Reposted by Thomas GorochowskiMany microorganisms modify their movement in response to light. This new #JRSocInterface paper has developed an integrated pipeline capable of acquiring temporal imaging data and extracting kinematics to create digital twins: doi.org/10.1098/rsif... @chofski.bsky.social
- 🫣 Now for something a little different from the lab: a data-centric approach to building digital twins as a route to control of emergent population level behaviours in microbial swarms 🤔 If that means nothing to you, then just check out the video! doi.org/10.1098/rsif... #engbio #control
- Reposted by Thomas GorochowskiNext in Lab's conference agenda: AI, Engineering Biology and beyond. It starts today in Bristol hosted by @chofski.bsky.social. Looks great: aiebab.github.io. From our side, @lewisgrozinger.bsky.social will be talking about our approach to the use of evolutionary algorithms for biocomputation.
- Reposted by Thomas GorochowskiIn Bristol for the week for the AI, Engineering Biology and Beyond conference hosted by @chofski.bsky.social. Very excited to meet the UK synthbio community. First day hackathon event was a blast!
- Cold and "nippy" 🥶 start to the #AIEBaB26 Hack-a-thon 💻. The students helping with the organisation have done an amazing job in pulling this all together. A big thank you to the @jgibristol.bsky.social and @aibio-uk.bsky.social for the support!
- If you work with R6K plasmids for transient DNA delivery, our latest SHARK strains might be of use! Work out at ACS Synthetic Biology led by Shivang Joshi and strains plus plasmids for their assembly will be available @addgene.bsky.social very soon! doi.org/10.1021/acss...
- If you are looking to integrate your latest genetic creation into the genome of your favourite bug, you might find our latest review now out in OUP Synthetic Biology useful. 🧬⚒️ Work led by Riesa Rohmat with input from Thea Irvine and Shivang Joshi. #genome #synbio doi.org/10.1093/synb...
- Reposted by Thomas GorochowskiSo you think your mammalian plasmids have nothing to fear from cloning and propagation in E.coli? Quantitative profiling of millions of nucleotides by Tom Copeman will prove you wrong! Supervised with the amazing @proftomellis.bsky.social and AZ, now on BioRxiv: doi.org/10.64898/202...
- Reposted by Thomas GorochowskiEmerging trends in genome integration tools for precision engineering of diverse bacterial species doi.org/10.1093/synb...
- 🚨 Last call for the 'AI, Engineering Biology and Beyond' conference taking place in Bristol on the 15-16 January 2026. There is a limited capacity and some places are still left, but worth signing up soon before the 19th December deadline! Register at: aiebab.github.io
- 📕My review for Jane Calvert's latest book, 'A Place for Science and Technology Studies' is out in Interdisciplinary Science Reviews! I really enjoyed the stories and learnt so mcuh. Well worth a read if you are interested in the ways that that study of science works: doi.org/10.1177/0308...
- End of year Science Bonanza is always something I look forward to, not only for hearing about what the team has been up to all year, but also for the amazing food everyone brings. Christmas has started proper now 🎅
- A couple new #PhD opportunities to join my lab at the intersection of #synbio, #plantsci and #biotech as part of the Plant BioDesign doctoral programme spanning the University of York, University of Cambridge, University of Bristol and John Innes Centre. 1/4
- (PhD 1) Join @PierreBuscaill and me to create SynProm, a modular synthetic biology toolkit for rapid, spatio-temporal monitoring of plant gene activity. Design, test & model synthetic promoters in Nicotiana benthamiana with a focus on plant immunity. 2/4 www.findaphd.com/phds/project...
- (PhD 2) Join Heather Whitney, me and others to take plant RNA synthetic biology to a new level. Create new biofacbrication processes to enable the robust and effective RNA delivery to turbo-charge agriculture. 3/4 www.findaphd.com/phds/project...
- Only available to UK applicants, and did I mention these studentships are part of the TechExpert pilot providing an enhanced annual (tax-free) stipend of £31,000. Do something amazing, and get paid for it!
- Very excited for this project with @pierrebuscaill.bsky.social! Will bring together a lot of exciting tools we have up and running in the lab for working with diverse biology and put them to use in building new technologies to trace gene expression across plants. 🧬 🔍 Applications open!
- 🚀 PhD opportunity! Join us (@pierrebuscaill.bsky.social & @chofski.bsky.social) in Bristol 🌱✨ Design, test & model synthetic promoters in Nicotiana benthamiana, focusing on plant immunity. Apply now! 🔗 www.findaphd.com/phds/project... #PlantSci #SyntheticBiology #PhD #PlantBioDesign #BristolUni
- The initial lineup of keynotes and spotlight talks is finalised, with 10 contributed talks still up for grabs! Come join us in Bristol on 15-16 Jan 2026 for AI, Engineering Biology and Beyond to shape the future of these fields🤖🧬🦠Register now at: aiebab.github.io
- 🚨Interested in the intersection of AI and Engineering Biology? 🤖🧬 If so, come join us in Bristol, UK from 15-16 Jan 2026 for the latest instalment of the "AI, Engineering Biology and Beyond" conference! It's going to be a "banger" and registration is open NOW! #synbio #ai aiebab.github.io
- Reposted by Thomas GorochowskiUniversité Grenoble Alpes opens a full professorship in microbiology in 2026. The selected candidate will develop their research program on quantitative approaches in microbiology in the Laboratoire Interdisciplinaire de Physique. More info: liphy.univ-grenoble-alpes.fr/en/join-us/r...
- Reposted by Thomas GorochowskiSHARK: a specialized host for assembling R6K plasmids biorxiv.org/content/10.1101/202…
- Reposted by Thomas GorochowskiSHARK: a specialized host for assembling R6K plasmids doi.org/10.1101/2025...
- 🛠️New tool from the lab! #SHARK🦈: a new strain to support complex cloning of transient R6K expression plasmids – perfect for genome engineering. Work led by the talented Shivang Joshi and all strains and strain assembly tools enroute to Addgene. #synbio doi.org/10.1101/2025...
- We've been using these strains in the lab for the past couple years and they are super solid. I should also point out this package will include a nice inducible λ-Red system called pREMORA! Big thank you to the supporters of the work including Dstl, BBSRC and @royalsociety.org.
- 🥳Excited to share our latest collaborative work using whole-cell models and #AI to design genomes!🦠🧬 What a time to be alive! Project led by Ioana Gherman, with Kieren Sharma, Joshua Rees-Garbutt, Claire Grierson, Lucia Marucci, Wei Pang & Zahraa Abdallah #synbio authors.elsevier.com/sd/article/S...
- Very excited to attend and speak at this years #UKOMAIN Multimodal AI workshop at the Barbican. Already learning a lot about emulators and generative models for novel materials.
- 🚨I have a fully funded 4-year #PhD opportunity in my lab on 'Tuneable multi-input genetic logic circuits for designer probiotics'.🦠 We'll be throwing all the tech we have at this one to make reliable engineering of diverse microbes a reality. Applicants must be UK national...
- Email me for further details or apply directly at: www.bristol.ac.uk/study/postgr... but be sure to mention Thomas Gorochowski as supervisor and funding from EPSRC IDLA.
- Come and join us at a free complementary Japan-UK Engineering Biology meeting after the main ESSL conference (essl2025.org/). A few spaces left to some see some of the up and coming superstars of #synbio in the UK!
- Standard day in Bristol... balloons!
- Reading some wonderful old Russian mathematics on automata theory and love this comment that just popped up! Coming from the rural countryside of Somerset, I'm not sure the people quite match this analysis! 🤠
- I've become obsessed by the idea of "design" in all aspects of synthetic biology. How do we discover good bio-design? How will it make me feel? Does it even matter? This awesome post by iA is the first that resonates in terms of how we might get there... ia.net/topics/maker...
- I'm so up for building a team to explore this approach for engineering biology. And it feels like the time is ripe to move beyond the pure stream of technology to a better point of understanding. No idea how I take this forward, but reach out if interested!
- Although I've now taken a back seat, it is great to see the growing adoption of SBOL Visual in the synthetic and engineering biology literature and even more awesome to see so many current and visiting students to my lab on the author list😍 Roll on 2035! arxiv.org/abs/2507.04601
- What to agument your favourite protein with new functionalities? 🛠️ We've got a #biodesign workflow to help with that! In work led by @georgiehs.bsky.social we present SIMPLIFE that blends biophyscial and #ML models to extend biology in useful ways. #synbio doi.org/10.1101/2025...
- Big thank you to @ukri.org and @royalsociety.org for supporting this work and great collaborations with the Parmeggiani and Steel labs!
- What to learn a bit about some of the topics explored at the Japan-UK Synthetic Biology Conference earlier this year? Then, check out our meeting report now out in ACS Synthetic Biology. Big thanks to all the authors and Patrick Cai and Masato Kanemaki for organising! #synbio doi.org/10.1021/acss...
- Great to see this report out from the UK Government Office for Science on 'Mirror Life'. Was nice to contribute to the discussions and thoughts on this topic with other UK colleagues. #synbio www.gov.uk/government/p...
- Some days I’m reminded of why working in research can be so exciting. Imaging DNA at the sub-nanometre scale on this beast! High-speed scanning #AFM for the win.
- Reposted by Thomas Gorochowski🚨Anyone want a job?🚨 We have two #postdocs up for grabs! 🧪 - cell developmental biology/#evodevo/#neuroevodevo - bioinformatics and molecular biology Both working on brain evolution in Heliconiini butterflies Details below! Please repost 🙏 1/n
- For those of you interested in the convergence of AI and Engineering Biology, keep the 15–16 Jan 2026 free. Next “AI, Engineering Biology and Beyond” #AIEBaB will be in Bristol, UK! Organisation currently underway and more info to follow soon!
- Recombinases your thing? In the latest from my lab, Veronica Greco shows how @nanopore sequencing + automated liquid handling provides the perfect platform for characterising these systems at scale! Awesome collaboration with @jennbrophy.bsky.social @sarah-guiziou.bsky.social doi.org/10.1101/2025...
- Had an awesome time at #IEEE #ASYNC2025 this year in the beautiful Portland OR. Such a vibrant and open community. Thanks to the organisers. Hopefully this is the start of some new intersections between asynchronous circuits and engineered biology!
- Loving the latest Pace Layers journal from the @longnow.org This article hit home to me on the small bits of reflection we all can do to better appreciate our place in this world. Worth a read. longnow.org/ideas/deep-t...
- Awesome visit to @royalsociety.org to see some of the treasures in their collection, followed up by a fun session with some of the Imperial #synbio "crew" feat. @proftomellis.bsky.social @ceronifranci.bsky.social Ouldridge Lab. Highlights were Micrographia and the TODO list of the early fellowship!
- Learn how Cas9-enrichment + @nanoporetech.com sequencing can more fully uncover biodiversity in complex environments via targeted metabarcoding in latest from lab! Led by the hugely talented Lucia Nikolaeva-Reynolds who started this as her final year undergraduate project! doi.org/10.1098/rsos...
- Big thanks to support from the Liv Sidse Jansen Memorial Foundation, @royalsociety.org, @ukri.org. @bristolbiosci.bsky.social @bristolbiodesign.bsky.social
- Reposted by Thomas GorochowskiInterested in a #postdoc in #originsoflife research? Are you a geek who loves #RNA, #RNAseq and tinkering, with a background in #biochemistry, #chemistry or #biophysics? Join #bubblelife! Apply now by email (CV + a short motivation letter)! cordis.europa.eu/project/id/1...
- Looking for a PhD? I have a fully funded one for UK nationals on engineering gene circuits in probiotic microbes. Will bring together a lot of existing stands of #synbio research in my group and push towards some exciting applications! Start date Sept 2025. Email me if interested! Pls RT
- Reposted by Thomas GorochowskiData-driven inference of digital twins for high-throughput phenotyping of motile and light-responsive microorganisms biorxiv.org/content/10.1101/202…
- Reposted by Thomas GorochowskiData-driven inference of digital twins for high-throughput phenotyping of motile and light-responsive microorganisms biorxiv.org/content/10.1101/202…
- Phenotyping motile microorganisms is always a challenge. In the latest from the lab led by Andrea Giusti, we show how our #DOME platform can speed up the processes, enabling data-centric inference of digital twins and routes to multicellular control! 🦠💨🔦 doi.org/10.1101/2025...
- This was an awesome collaboration with Mario di Bernardo's lab and builds on the foundational development of the #dome with @sabinehauert.bsky.social. Also, wouldn't have been possible without support from the @ukri.org and @royalsociety.org. @bristolbiodesign.bsky.social @bristolbiosci.bsky.social
- Reposted by Thomas GorochowskiExperimental evolution of evolvability | Science www.science.org/doi/10.1126/...
- Reposted by Thomas GorochowskiJust now in Science: Researchers at the Institute for Protein Design report a computationally-designed, multi-step enzyme. Learn how they did it: www.asimov.press/p/ai-enzymes
- Reposted by Thomas Gorochowski
Happy International Women and Girls in Science Day. I celebrate Emily Noether, capturing the remarkable relationship between conservation and symmetry in Noether's theorem. Einstein said she was a "creative mathematical genius." - Wow!
- ÅNGSTRÖM-RESOLUTION IMAGING OF CELL-SURFACE GLYCANS 🧬🎨🍬 The glycocalyx, our cells' sugar coat, holds secrets in immunology, cancer, viral infections, and more. Visualizing its molecular architecture was impossible… until now. #glycotime #microscopy www.biorxiv.org/content/10.1...
- Reposted by Thomas GorochowskiIt’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.
