Angel Goñi-Moreno
Computing with living systems | Synthetic biology. Head of the Biocomputation Lab at the CNB-CSIC @cnb-csic.bsky.social
www.biocomputationlab.com
- On my way to Copenhagen for the ALICE workhsop @aliceworkshop.org! Discussions around #ALIFE topics for a full week — looking forward. I'll be talking about cellular computing (what else? :-)
- New tech adventure: co-founded Newton Biotwins together with @mirobueno.bsky.social. We're building #DigitalTwins for the lab — starting with a flow cytometry twin. Turning #biology into an information science! newtonbiotwins.com/en/home_en/
- Next in Lab's conference agenda: AI, Engineering Biology and beyond. It starts today in Bristol hosted by @chofski.bsky.social. Looks great: aiebab.github.io. From our side, @lewisgrozinger.bsky.social will be talking about our approach to the use of evolutionary algorithms for biocomputation.
- Just published our workflow for genotyping transposon libraries. All methods, files, scripts... are open source and publicly available. 🔗 link.springer.com/article/10.1...
- The biological messiness, as the quantum weirdness, as a source of (unconventional) computing.
- New paper out!📢 Exploring the computing power of microbes that shapes the environment. In this short review we talk about the "complexity gap", the distance between bottom-up genetic circuits and microbial information processes. Key questions to improve #biocomputation. 🔗 doi.org/10.1016/j.mi...
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- Side story: NAND gates where one input deals directly with growth control, and it is the actual physical body doing the computation. This is our initial approach to morphological computing in living cells. #biocomputation #alife Our new strain KT-TTX is truly fascinating. Feedback welcome!
- Preprint out! By controlling growth, via RNAP, we control the entire cellular machinery, and tune the cellular context into distinct, stable states. See how NOT gates behave! Kudos to @angeles-hg.bsky.social and @mirobueno.bsky.social 🔗https://www.biorxiv.org/content/10.64898/2025.12.19.695408v1
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- Preprint out! By controlling growth, via RNAP, we control the entire cellular machinery, and tune the cellular context into distinct, stable states. See how NOT gates behave! Kudos to @angeles-hg.bsky.social and @mirobueno.bsky.social 🔗https://www.biorxiv.org/content/10.64898/2025.12.19.695408v1
- Reposted by Angel Goñi-Moreno🔔 Exciting News from the ALIFE Community 🔔 We are pleased to share that the proceedings of ALIFE 2025, the 2025 edition of the premier conference on artificial life, held in Kyoto are now published and accessible - direct.mit.edu/isal/proceed...
- This book is brilliant. Impossible to read without current scenarios in mind...
- Huge news for #biocomputation! In a major call (€30M total) for AI proposals, Spain just funded an initiative for implementing AI with living matter using #synbio as the programming tool. The 'AI in vivo project' is a massive, official recognition of biocomputation as a leading field in computing.
- 2⃣ equipos #CNB participan en nuevos proyectos de investigación en #InteligenciaArtificial 'GRAINS', coordinado desde la @uc3m.es, y 'AI en vivo', coordinado por @upm.es ➡️Iniciativas subvencionadas en la convocatoria de la #AEI ( @cienciagob.bsky.social) www.cnb.csic.es/nuevos-proye... @csic.es
- Reposted by Angel Goñi-Moreno2⃣ equipos #CNB participan en nuevos proyectos de investigación en #InteligenciaArtificial 'GRAINS', coordinado desde la @uc3m.es, y 'AI en vivo', coordinado por @upm.es ➡️Iniciativas subvencionadas en la convocatoria de la #AEI ( @cienciagob.bsky.social) www.cnb.csic.es/nuevos-proye... @csic.es
- The CSIC @csic.es Doctoral Programme in #SyntheticBiology is currently offering 10 PhD positions on a number of projects. Good opportunities! syntheticcell.eu/synbio-csic-...
- El disco de Ana Crismán es alucinante! Como aficionado al flamenco me ha encantado. Muy valiente, muy bonito. Como guitarrista me he quedado un poco descolocado 😅 arpaflamenca.es
- Our #ALIFE2025 paper is out! 🎉 We show that even when two circuits produce the same output, their evolutionary potential can differ greatly. #Evolution at the smallest scale. “Parameter Evolvability in Gene Expression Models Drives Phenotypic Adaptation” 🔗 direct.mit.edu/isal/proceed...
- In Wikipedia, the German entry for DNA computer mentions the cellular supremacy de.wikipedia.org/wiki/DNA-Com...
- Next in the Lab's conference agenda: Synthetic Biology UK #SBUK. Always a target event for us! Look for Lewis @lewisgrozinger.bsky.social to hear about biocomputation and evolution: "Evolutionary algorithms to design biocomputing circuits beyond logic gates" - an upgrade of our #ALIFE 2023 story.
- If you are at the Emerging Applications of Microbes conference in Leuven, go to poster #24: Engineering growth control to modulate circuit host dependencies, by @angeles-hg.bsky.social. This is a brilliant story about growth rates vs. genetic circuit function. And, of course, noise! #synbio
- The 2025 Retreat of the Biocomputation Lab (in wonderful Chinchón, Madrid) comes to an end. Three days of fantastic discussions, with new (and revisited) goals ahead. What a brilliant team!
- Vuelvo de dar un seminario sobre biocomputación en la escuela de teatro de Jorge Eines. Cosas de aquí, de Madrid.
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- I'm at a meeting on Unconventional Computing in... Bristol docks! Notes: 1) discussions around Turing Machines are endless, as infinite as the tape, and 2) reservoir computing with all physical substrates (not sure about this trend being the best but here we are).
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- Off to Madrid from an amazing #ALIFE2025 conference in beautiful Kyoto. Kudos to the organisers.
- Last day in #ALIFE2025 talking about evolutionary robotics. Sounds like here "evolution" and "learning" are clearly separated. I'm still unsure what is the interplay between #evolution, #learning and #adaptability. Surely, #information, #knowledge and #memory are keywords in this discussion.
- I am a bit skeptical here I guess... At least when it sort of matches the lego brick metaphor in #synbio.
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- 1st evolution session of the day at #ALIFE2025. Our story on evolvability by Pablo Japón. In evolution, it is not only the visible that matters!
- My first day at #ALIFE2025 was about 1) noise and 2) information. Noise as a perturbation that pushes a system outside viability, or as a resource for computation. Two views that are not the same but complementary. Information leads to (is?) correlation and knowledge (memory?). Most inspiring talks!
- Making the most of Kyoto after a great #ALIFE2025 first day. Here training with the Kyoto University #Judo Club!
- I hear new definitions of evolution and open endedness every now and then. I wonder if the definition itself is evolving.
- Off to #ALIFE conference @alife2025.bsky.social in Kyoto! Although I've been involved in many, this is the first ALIFE I attend since Odense 2012 😅. Pablo Japon will be presenting our work on evolvability in #synbio - Wed at 9 in the Auditorium.
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- Reposted by Angel Goñi-MorenoBreaking News: Jane Goodall, one of the world’s most revered conservationists, died at 91. Her discoveries in the 1960s about how chimpanzees behaved in the wild broke new ground and represented what was called “one of the Western world’s great scientific achievements.” nyti.ms/42kpGxt
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- ¡Qué bonita está Madrid esta tarde!
- The use of evolutionary algorithms offer an interesting advantage for optimising #synbio designs: exploring non-intuitive solutions. We showed this at ALIFE 2023 (paper linked) and will again at #ALIFE 2025 next month! direct.mit.edu/isal/proceed...
- Wow!! This work is great - I'll need to dig out some old ideas on "quantum synthetic biology". This from our 2019 cellular supremacy paper:
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- Journals struggling with LaTeX submissions in 2025.
- Brilliant news here! Our manuscript on evolvability was accepted for presentation at @alife2025.bsky.social. So there is a new item in the Lab's conference agenda: #ALIFE Kyoto! More on this coming soon...
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- Next in Lab's conference agenda: Designer Biology! www.efbiotechnology.org/designerbiol... Paula Múgica has a poster on her recently published quorum sensing tools, and Crislaine Rocha will talk about environmental biosensors as input to logic gates.
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- Great session! A pity it was only 2'5h and not the full day 😅. Computing with oscillations encoding information in frequency, distributed computing with high information capacity wires, neuromorphic computing at the verge of learning, stochastic and probabilistic computing, heterotic computing...
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- The NEWTON project got funded, let's go! #DigitalTwins on their way...
- New toy! Just need some free time now to play with it... Sure we can get ideas for new genetic circuits 🤔
- Next in Lab's conference agenda: FEMS @femsmicro.org! @vdlorenzo.bsky.social and myself are running a session on bacterial computation. Talks by @yschaerli.bsky.social, @manishmicrobe.bsky.social, Sangram Bagh & organisers. Very looking forward to it! #biocomputation #synbio
- Many genetic circuits we design don't get through the DNA synthesis stage. They just cannot be built. This is not the future I was told about in 2010 😅
- Next in the Lab's conference agenda: the @embl.org symposium on New approaches and concepts in #microbiology. Look for @juanricomol.bsky.social!
- Of course! Couldn't be otherwise 😉 Huge congrats, Lorea @loraleja.bsky.social! #ME16
- Lorea Alejaldre, from our lab, is at the Metabolic Engineering 16 #ME16 meeting in Copenhagen this week. Look for her if you want to engage with the Biocomputation Lab.
- Lorea Alejaldre, from our lab, is at the Metabolic Engineering 16 #ME16 meeting in Copenhagen this week. Look for her if you want to engage with the Biocomputation Lab.
- On my way to the conference of the Spanish Society of #Microbiology! Very happy to be invited to show our research on computing with microbes. Looking forward to meeting with friends (and making new ones)!
- Just out! Want to use quorum sensing (QS) for cell–cell communication? Check this out — you might find it useful! Kudos to Paula Múgica 👏 Standardized Quorum Sensing Tools for Gram-Negative Bacteria | @pubs.acs.org @acs.org #SyntheticBiology @sevaplasmids.bsky.social pubs.acs.org/doi/10.1021/...
