Irina Dudanova
Neuroscientist, Professor at University Hospital Cologne, @unicologne.bsky.social
My lab studies molecular and circuit mechanisms of neurodegeneration.
- New preprint from the lab by Dennis Feigenbutz et al.: Using #snRNA-seq, we explore vulnerability profiles of cortical cell types in #HuntingtonsDisease mice and identify ER-phagy as a new pathway in HD pathogenesis. www.biorxiv.org/content/10.1...
- Reposted by Irina DudanovaJob Alert! The Institute for Neuro- and Behavioural Biology at the Faculty of Biology @uni-muenster.de invites applications for a Full Professorship (W3) in “Systems Neuroscience” - Highly attractive research environment at the Multiscale Imaging Center. Apply by January 5th. See shorturl.at/VczFp
- Reposted by Irina DudanovaWe are hiring a postdoc to work @istaresearch.bsky.social on an @erc.europa.eu funded project, investigating the control of behavior and physiology by the hypothalamus. Please apply and share! ist.ac.at/en/job/postd...
- Reposted by Irina DudanovaEarly-career researchers: want to run your own lab? 🌟Max Planck Research Groups offer 6+ years, up to €2.7M in funding, open-topic freedom, team support & tenure-track opportunities. Intrigued? 😃Apply by Oct 14, 2025! www.mpg.de/max-planck-r...
- Congratulations to Cole Sitron et al. from Ulrich Hartl's group @mpibiochem.bsky.social on this beautiful study exploring the interaction of α-synuclein aggregates with the ESCRT-III complex, now out in @cp-molcell.bsky.social - it was a pleasure to contribute to the project.
- Reposted by Irina DudanovaTrilled to share our new work🥳We show that age-related hyperactivation of the EPS8/RAC signaling pathway drives protein aggregation and neurodegeneration — hallmarks of Huntington’s disease and ALS. #proteostasis #aging #neurodegenerativediseases
- 🚨 New from our lab: Here we explored how aging contributes to harmful protein aggregation in diseases like Huntington’s & ALS. The culprit? An overlooked aging factor — EPS8 and RAC signaling. #Aging #Longevity #Proteostasis #ALSResearch 🧵 www.nature.com/articles/s43...
- Reposted by Irina DudanovaNew lab preprint: Leveraging the updated AutoGaitA toolbox, we revealed distinct species-specific mechanisms to generate propulsion during walking and the conserved pattern of age-related propulsive decline from flies to humans. www.biorxiv.org/content/10.1...
- Reposted by Irina DudanovaApply now for a fully funded #PhD position at the Cologne Graduate School of Ageing Research and become part of our vibrant #AgingResearch commmuny. 🗓️ Deadline: November 3, 2025. ℹ️ More info: www.ageing-grad-school.de 📣 Spread the news!
- Reposted by Irina DudanovaWe have a 4-year postdoc position open in our Research Unit on proteostasis! The project explores inter-tissue regulation using advanced proteomics approaches. Collaborative & interdisciplinary environment. More details & application here: jobs-uk-koeln.onlyfy.jobs/job/pktg6ivj...
- Reposted by Irina DudanovaNew work from our lab;)
- C9orf72 ALS-causing mutations lead to nucleoporin Nup107 aggregation and subsequent pathological changes biorxiv.org/content/10.1101/202…
- Reposted by Irina Dudanova🚨 Scholarship Alert! 🚨 Pursue your Master studies in Biology or Biochemistry with our #CGA Master Fellowship programme. 🧬👩🏽🔬💰 Explore ageing research at the Cologne Ageing Campus! Apply by July 15! 📅 🔗 Learn more: www.ageing-grad-school.de/master/maste...
- Delighted to be part of the new Research Unit on Organismal Proteostasis. Thanks to @thevilchezlab.bsky.social for all the hard work on putting together this consortium, and to the #DFG for funding our research!
- Happy to share our new preprint, where we find that anle138b reduces Huntingtin inclusions and improves disease phenotypes in #Huntington’sDisease models, showing its potential as an HD treatment. Great work by Miguel Padilha and several wonderful collaborators including thevilchezlab.bsky.social
- Anle138b ameliorates pathological phenotypes in mouse and cellular models of Huntington's disease biorxiv.org/content/10.1101/202…
- Reposted by Irina DudanovaMitochondria a safe haven for aggregation-prone proteins? #neurodegeneration. #Parkinson. Find our latest manuscript in @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...
- Reposted by Irina DudanovaInterested in the molecular mechanisms of neurodegeneration? 📢 We are looking for a PhD student interested in studying the role of TDP-43 in genome stability and the DNA damage response! Apply via this fantastic PhD Programme until April 3 👇
- The summer call of our International PhD programme is open! 📢 Ready to advance your scientific career? If you're passionate about #RNAbiology, #Bioinformatics, or #Immunology, apply to our open calls and join our global community of over 200 #PhD students! 🌍 www.imb.de/phd
- Reposted by Irina DudanovaOur new paper shows that targeted stimulation of a subtype of cortical inhibitory neurons can ameliorate motor deficits in Huntington’s disease mice. A great collab with @irinadudanova.bsky.social www.biorxiv.org/content/10.1...
