Davies Lab
James Davies Lab, Oxford University
- Reposted by Davies LabExcited to share that a part of my PhD work is online now on BioRxiv! www.biorxiv.org/content/10.6... We developed a genome editing approach to target the JAK2 V617F mutation and demonstrate its potential to alleviate MPN hallmarks in primary patient cells. Thread 👇
- Reposted by Davies LabThanks so much for highlighting our images created with @rcollepardo.bsky.social
- Mapping chromatin's structure at base-pair resolution reveals how it mediates cis-regulatory element interactions 📹 Hangpeng Li et al @jojdavies.bsky.social, MRC Molecular Haematology Unit, @imm.ox.ac.uk @ox.ac.uk in @cellpress.bsky.social ➡️ bpod.org.uk/archive/2025...
- Reposted by Davies Lab#WIMMReads: Oxford scientists, led by James Davies at the MRC WIMM, have captured the genome’s structure in unprecedented detail. 🧪 Read the full story below 👇 @ox.ac.uk @davieslab.bsky.social @jojdavies.bsky.social @medsci.ox.ac.uk
- Scientists have the most detailed view yet of how DNA folds and functions inside living cells! The breakthrough helps us understand how genetic differences lead to disease and opens up fresh routes for drug discovery 👇 shorturl.at/nQjsx @jojdavies.bsky.social @imm.ox.ac.uk @medsci.ox.ac.uk
- Reposted by Davies LabOur new preprint 🧬🔗 www.biorxiv.org/content/10.1... BRD4-NUT forms liquid-like condensates that locally constrain nucleosomes via BRD4-mediated crosslinking— physical control of #chromatin by #LLPS transcription condensates. @semeigazin.bsky.social @katsuminami.bsky.social @masaashimazoe.bsky.social
- We’re really excited to see Hangpeng Li present our latest work at the CSH Mechanisms of Eukaryotic Transcription meeting.
