Gene Chong
Senior Editor at Nature Chemical Biology handling #glycotime, #lipidtime, immunology, microbiology, protein engineering, #synbio, #computational. Formerly a comp chemist simulating various things. Based in DC.
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- Reposted by Gene ChongOut now in @natchembio.nature.com: Xylosyltransferase engineering to manipulate proteoglycans in mammalian cells 🎉 www.nature.com/articles/s41... check out the press release below! #glycotime
- Researchers at the Crick, @imperialcollegeldn.bsky.social and @tudresden.bsky.social have worked out a method to track and analyse complex molecules that sense external messages crucial for cell growth and behaviour. www.crick.ac.uk/news/2026-01...
- Reposted by Gene ChongJob vacancy: Nature Chemical Biology is hiring Nature Chemical Biology is seeking an Associate or Senior Editor. This is a permanent full-time position within the editorial team. The vacancy is for one of the offices based in USA or China. springernature.wd3.myworkdayjobs.com/en-US/Spring...
- A new paper from @zhilindseylin.bsky.social @jimwellsucsf.bsky.social and colleagues presents temporal mapping of extracellular and intracellular neighborhoods of a protein of interest with MultiMap photoproximity labeling proteomics, here applied to EGFR www.nature.com/articles/s41...
- The fusion of intrinsically disordered regions to CARs enhances CAR-T signaling by inducing CAR condensation and enhances CAR sensitivity to low-antigen-expressing cancer cells www.nature.com/articles/s41...
- I loved this simulation-guided paper with reaaally state-of-the-art simulations at first sight 😍
- Are the lipids associated with static protein structures there as long-lived ligands or an effect of preferential solvation? This computational-experimental framework shows the way! #lipidtime #compchem www.nature.com/articles/s41...
- Are the lipids associated with static protein structures there as long-lived ligands or an effect of preferential solvation? This computational-experimental framework shows the way! #lipidtime #compchem www.nature.com/articles/s41...
- Engineered bispecific Notch agonists “pull” on and mechanically activate Notch receptors in the presence of desired biomarkers www.nature.com/articles/s41...
- Reposted by Gene ChongVery excited to share new work out today in @natchembio.nature.com on a new approach - FACES - for selectively imaging of phospholipids and other biomolecules at spatial resolutions down to individual membrane leaflets (1/n) www.nature.com/articles/s41...
- The design of STAT biosensors enables real-time tracking of STAT activation in live cells, inhibitor screening, and probing the activity of cancer-associated STAT mutants www.nature.com/articles/s41...
- Arginylation is a post-translational modification that is difficult to distinguish from arginine residues using mass spec. Now a method has been developed to profile protein arginylation ex vivo www.nature.com/articles/s41...
- The Red Hen in DC for Italian food. I had to wait a month for the reservation! Worth it
- #glycotime #immunology Structure-guided design rules for antibodies targeting cancer antigens with Tn and STn epitopes www.nature.com/articles/s41...
- A new paper reports that the primary mechanism of capsaicin entry into the vanilloid-binding site of TRPV1 is a targetable hydrophobic tunnel at the TRPV1-membrane interface www.nature.com/articles/s41...
- #glycotime Legionella effector LtpM is found to recognize strict two-residue sequons for site-specific O-glucosylation with minimal perturbations to a target protein and is used to show that O-glucose can act as a constitutively active O-GlcNAc mimic www.nature.com/articles/s41...
- Reposted by Gene ChongMolecular recording of cellular protein kinase activity with chemical labeling: www.nature.com/articles/s41... Congratulations to De-en Sun and the entire team.
- Reposted by Gene ChongThe newest paper from the lab is now out @natchembio.nature.com! A hard-won effort by Rebecca and @xujunc.bsky.social uncovers a previously undescribed post-translationally modified site that regulates STING signaling and proposes a new strategy for inhibition. www.nature.com/articles/s41...
- oh god 😖 🤦🏻♂️
- A new paper from the Institute for Protein Design at UW presents RFpeptides, an extension of RoseTTAFold2 and RFdiffusion for de novo design of macrocyclic peptide binders www.nature.com/articles/s41...
- Another cool protein eng. paper for you -- Designed "chauffeurs" shuttle transporters and integral membrane enzymes folded in the ER to the peroxisomal membrane. This expands the repertoire of biosynthetic pathways that can be compartmentalized in the peroxisome www.nature.com/articles/s41...
- and check out the associated News & Views by Yang Zhou, Xiaoding Ma, and Haifeng Ye on the innovations of this chemically induced proximity system called SAMBA www.nature.com/articles/s41...
- A highly compact chemically induced proximity system dependent on salicylic acid or aspirin enables control of biological processes and cellular therapeutics using an over-the counter drug with minimal side effects www.nature.com/articles/s41...
- A highly compact chemically induced proximity system dependent on salicylic acid or aspirin enables control of biological processes and cellular therapeutics using an over-the counter drug with minimal side effects www.nature.com/articles/s41...
- “if it is allowed…” 😞
- c-di-AMP is found to be a second messenger in eukaryotes generated by ADCY7 and connects TLR9 stimulation to NLRP3 inflammasome activation #immunology #ChemBio www.nature.com/articles/s41...
- My first Memorial Day Weekend spread 🤤
- It’s #lipidtime. The authors capture oscillations in the abundance of different phospholipid species during the yeast cell cycle, suggesting regulation and interplay of phospholipid synthesis, membrane fluidity, and metabolic efficiency during cell division www.nature.com/articles/s41...
- Here to report UltraSelex which uses single-round selection and ranking algorithm for high-affinity RNA aptamer discovery #RNA #ChemBio #chemsky #drugdiscovery www.nature.com/articles/s41...
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- A first-in-class inhibitor of the PASB domain of circadian regulator BMAL1 is reported with an important tie-in to the crosstalk between circadian biology and immunology #chemsky #ChemBio www.nature.com/articles/s41...
- I think I got the wrong booster at the doctor's (tetanus instead of MMR) now that there's a measles case in DC 😐
- We grew up learning about ribosomes in science textbooks, and it's cool that we're just now starting to really see that they're structurally and functionally heterogeneous. Also in reference to a recent Science paper www.science.org/doi/10.1126/.... Long live science!
- Out just now @naturecomms.bsky.social: using cryo-EM and cryo-electron tomography, we provide evidence that structurally heterogeneous ribosomes can cooperate in protein synthesis in bacterial cells: www.nature.com/articles/s41...
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- Ligand-controlled transportable condensates to different cell compartments! Enjoy! #ChemBio #synbio www.nature.com/articles/s41...
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- It's kind of annoying how I come up with my best writing (e.g. for Research Highlights) in the shower but forget it when I get out
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- This Italian market in DC was a discovery. The best variety of vermouths, gins, bitters, and mid- and high-range European wines 😍
- I don't know if I can report the exact number of papers, but the number I've gone through is a very big number considering it's only February, and it makes me feel 😵💫
- A TRPM4 agonist is discovered, but very potent as it leads to sodium overload and a unique type of necrotic cell death #ionchannels #drugdiscovery #ChemBio www.nature.com/articles/s41...
- A binary population of biomimetic membraneless organelles delivers molecular messages with controllable feedback #synbio #ChemBio www.nature.com/articles/s41...
- I come back to this album so much (Muse - Absolution), and it's channeling the shock, anger, and sadness I feel and the edge I need into a coherent wavelength right now
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- A compound binding to a site peripheral to the KCNQ2 pore acts as either a channel activator (Ebio2) or inhibitor (Ebio3) by a change of a functional group, with the inhibitor having a unique mechanism causing the channel gates to close #ionchannel #ChemBio #chemsky www.nature.com/articles/s41...
- And out now from @synbiogaolab.bsky.social: Engineering of a human-derived protease controlled exogenously by its FDA-approved inhibitor enables control over cytokine activity in cell-based therapies with reduced risk of immunogenicity #synbio #ChemBio www.nature.com/articles/s41...
- #synbio is still going strong in January: A signal amplification circuit based on recycling nucleic acid inputs (called polymerase strand recycling) improves the sensitivity of transcription factor-based cell-free biosensors www.nature.com/articles/s41...
- Someone dropped flowers in front of my door? Thanks!
- A new paper from Lingchong You's group develops a cool amplification circuit that expands the dynamic range of plasmid transfer #ChemBio #synbio #microsky www.nature.com/articles/s41...
- It’s #glycotime Fucosyltransferases FUT10 and FUT11 are protein O-fucosyltransferases (POFUTs) modifying proteins with elastin microfibril interface (EMI) domains. Curious to know the function(s) of O-fucosylating EMI domains www.nature.com/articles/s41...
- I'm happy to see this paper I handled finally out! -- Directed evolution in mammalian cells using an orthogonal alphaviral RNA replication system with antiviral-induced mutagenesis #ChemBio #synbio www.nature.com/articles/s41...
- What? I have to return to work in the morning?
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- The Nature Chem Bio account nchembio.bsky.social is up and running! Please give it a follow. Our January issue will also go live before the new year 😉 #ChemBio #chemsky
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- I’m a regular at Astoria now (recognized by the waiters)! 🥹 If you’re ever in DC, it’s my favorite, \textit{the best}, spot
- I’m the Protein-Powered Poet of Bluesky. The Dating App Bio is on point with my love for antibodies 🤣 blueskyroast.com
- This issue looks 🔥 for protein engineering, #synbio, immunology, #biotech and throw in quantum effects in water networks
- Two new studies in Science describe synthetic biology-based strategies that expand the possibilities of harnessing immune cells to treat disease. Learn more in this week's issue: scim.ag/49nfztS
- I’m a Swiftie 😁 And I don’t know what art rock is but Rainy Day Rock is my perennial mood
- Reposted by Gene ChongCould one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from gene expression and real-time fluorescence to modulation..
- I love anything immune synapse
