Chen Wang: There’s another Retron Eco8 paper published in Molecular Cell today: Molecular mechanism of Eco8-mediated anti-phage defense: Molecular Cell www.cell.com/molecular-ce...

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Chen Wang chenwang.bsky.social · Oct 30, 2025
I’m thrilled to share our Retron Eco8 paper published in Molecular Cell today. Thanks all Fu lab members and our collaborators. 👉Phage SSB detection by retron Eco8 msDNA unleashes nuclease-mediated immunity. www.cell.com/molecular-ce...
Phage SSB detection by retron Eco8 msDNA unleashes nuclease-mediated immunity

The cryo-EM structure of the retron Eco8 system reveals an autoinhibited 4:4:4 complex of RT, msDNA, and OLD nuclease. Phage SSB binding to msdDNA unleashes non-specific nuclease activity to restrict ...

cell.com

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Chen Wang chenwang.bsky.social
There’s another Retron Eco8 paper published in Molecular Cell today: Molecular mechanism of Eco8-mediated anti-phage defense: Molecular Cell www.cell.com/molecular-ce...
Molecular mechanism of Eco8-mediated anti-phage defense

Yuan et al. uncover how the bacterial defense system Eco8 detects and combats phage infection. Through structural and biochemical analyses, they show that phage ssDNA-binding proteins trigger Eco8 act...

cell.com
Oct 30, 2025 15:08
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