Chen Wang
Postdoc | UMass Chan Medical School @umasschan.bsky.social | biochemistry & structural biology
PhD | Australian National University | host-microbe interactions
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- I’m thrilled to share our Retron Eco8 paper published in Molecular Cell today. Thanks all Fu lab members and our collaborators. 👉Phage SSB detection by retron Eco8 msDNA unleashes nuclease-mediated immunity. www.cell.com/molecular-ce...
- There’s another Retron Eco8 paper published in Molecular Cell today: Molecular mechanism of Eco8-mediated anti-phage defense: Molecular Cell www.cell.com/molecular-ce...
- Reposted by Chen WangStructural insights into type I and type II Lamassu anti-phage systems biorxiv.org/content/10.1101/202…
- Thrilled to share our new paper uncovering the defense mechanism of Retron-Septu antiphage systems! Grateful to the incredible Fu lab team, our outstanding colleagues at UMass Chan and OSU, and wonderful collaborators at UCSD for their support and contributions.
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- Reposted by Chen Wang🧬🧫🦠 @science.org Bacterial reverse transcriptase synthesizes long poly-A–rich cDNA for antiphage defense | Science www.science.org/doi/10.1126/... #microbiology #bacteriophage #antiphage #immunity #DNA #RNAsky #RT #Cryo-EM #DRT9
- Reposted by Chen WangExcited to share my PhD work in the Kranzusch Lab published in @nature.com! Two key discoveries: - Nucleotides can act as negative regulators of antiviral immunity - Ion channel activation is gated by DNA Thank you to our all collaborators! @soreklab.bsky.social www.nature.com/articles/s41...
- Reposted by Chen WangOut in Nature today: A new immune signaling molecule, His-ADPR, is produced by defensive TIR domain proteins in bacteria to protect from phage Joint work with the Tamulaitienė and Kranzusch labs www.nature.com/articles/s41... Congrats Carmel Avraham, Dziugas Sabonis, Renee Chang and co-authors!
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- So excited to see a Fu Lab trainee take the stage at #ASBMB25! Great to see our lab represented.
