Scott Coyle
signaling systems and protein circuitry. reimagining what cells can be. fun posts only. Assistant Professor:
@uwbiochem | Postdoc: @stanford @prakashlab | Ph.D.:
@ucsf Wendell Lim @CDI_UCSF
- Reposted by Scott CoyleThx for @mollyherring.bsky.social for featuring our recent work with @centriolelab.bsky.social and our quest with @gautamdey.bsky.social & the support of the @moorefound.bsky.social to look for the beauty in every #eukaryote out there using #Expansion #Microscopy #UExM
- Even with the largest zoom on a classic compound optical system, scientists struggle to make sense of finer details. Microbiologists are turning to an unexpected source to clear things up: a moisture-absorbing material found in diapers. www.quantamagazine.org/expansion-mi...
- Reposted by Scott CoyleNow in print at ACS Synbio! Introducing Aviatar: a concept for inducible translocation to any cell compartment using only a 1-component probe pubs.acs.org/doi/10.1021/...
- Reposted by Scott CoyleOur company has a new name, Eira Bio (www.eirabio.com) (formerly K2 Therapeutics), but the same important mission to apply our advanced synthetic biology, directed evolution, and protein design technologies to discover and develop next-generation antibody-based medicines for a range of diseases!
- Reposted by Scott CoyleOur new paper just out! pubs.acs.org/doi/10.1021/...
- Reposted by Scott Coyle#SynBYSS conference is scheduled on Jun 8-11, 2026 in Barcelona. Given the 100-year celebration of Architect Gaudi in Barcelona, we suggest early booking of hotels. Details can be found: www.jcvi.org/events/synbyss (speakers, abstract submission & registration) @jcvi.org @marcguellc.bsky.social
- Reposted by Scott CoyleOut in @physrevlett.bsky.social: @sfuphysics.bsky.social postdoc Antonio Patrón Castro (in tight collaboration with my colleague John Bechhoefer) pushes our information engine to higher dimensions! doi.org/10.1103/xwjd...
- Reposted by Scott CoyleWe've got a new preprint posted, you can read all about it (and see a picture of our recently adopted lab mascot) here: eltinglab.github.io/news/taylorB... The bottom line of this work is that we reveal new ways that S. pombe spindle biochemistry is regulated by force from the nuclear envelope.
- Reposted by Scott CoyleOur CytoTape work is published today in Nature @nature.com! CytoTape is a genetically encoded, flexible, intracellular protein tape recorder for spatiotemporally scalable and multiplexed recording of cellular activities continuously across weeks in vitro and in vivo. www.nature.com/articles/s41...
- Reposted by Scott CoyleAlex Pretti was a colleague at the VA. We hired him to recruit for our trial. He became an ICU nurse- I lover working with him. He was a good kind person who lived to help and these fuckers executed him. White. Hot. Rage.
- Reposted by Scott Coyle"Use it or lose it." This is great advice for exercise, but when cells need to slow down or go dormant, they need to store ribosomes to recover growth in the future. They use hibernation factors to do this. Here is our latest story on how archaea hibernate ribosomes (1/7): doi.org/10.64898/202...
- Reposted by Scott CoyleLatest collection of papers on mitochondria in health and disease! #MitochondrialDisease #week3 biomed.news/bims-mitdis/... @biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social www.nature.com/articles/s42...
- Reposted by Scott Coyle📢 Open faculty position – Origins of Life We have an opening in our section at the University of Geneva! 🧬🚀 SPREAD THE WORD Apply here: jobs.unige.ch/www/wd_porta...
- Yet another fantastic study by my amazing colleague @jasonrcantor.bsky.social -- the spatiotemporal organization of glycolytic machinery / ATP production at play here is so interesting. Congrats to @thebiokimist.bsky.social and the team on a beautiful paper!
- For ~century, we’ve asked: why do proliferating cells ferment glucose even when O2 is around? I’m thrilled to share our latest work @natmetabolism.nature.com, led by @thebiokimist.bsky.social. By leveraging conditional essentiality in HPLM, we propose a provocative new answer to this classic Q. 🧵
- Reposted by Scott CoyleFor ~century, we’ve asked: why do proliferating cells ferment glucose even when O2 is around? I’m thrilled to share our latest work @natmetabolism.nature.com, led by @thebiokimist.bsky.social. By leveraging conditional essentiality in HPLM, we propose a provocative new answer to this classic Q. 🧵
- Reposted by Scott CoyleThrilled to share our latest study, led by @reikatei.bsky.social, in @natchembio.nature.com! We began by asking a simple question—how do cells know if they have too much of a lipid in a particular membrane, and how do they respond to rectify this imbalance? www.nature.com/articles/s41... More info 👇
- Reposted by Scott CoyleThrilled that the lab's first @hhmijanelia.bsky.social project is up on bioRxiv! Story behind the story to follow. www.biorxiv.org/content/10.6...
- Reposted by Scott CoyleNew preprint! We found that the flavin-dependent halogenase RebH catalyzes sequence-tolerant Trp bromination in peptides 🧪https://www.biorxiv.org/content/10.64898/2025.12.17.694899v1
- New in ACS SynBio: led by Dennis Bolshakov, we used the awesome power of yeast to define how expression levels, noise, and sequence program the dynamics of synthetic protein waves, allowing us to genetically encode new cellular timescales stable over generations! pubs.acs.org/doi/full/10....
- Reposted by Scott Coyle🚨New preprint(1/2)! We show that RTK fusion oncoproteins broadly suppress EGFR signaling. How? Sequestration of adapters as the shared principle. Led by superb PhD student Carol Gao. www.biorxiv.org/content/10.1... Implications for drug tolerance/resistance, and includes one big surprise🫧.👇
- Reposted by Scott CoyleJust got word that we are a go for the Bacterial Cell Biology and Development GRS and GRC at Southern New Hampshire University! GRS will be on June 5-6, 2027 GRC will be from June 6-11, 2027 Block off your calendars Prokaryotic Cell Biologists! More details to come! Please repost!
- Reposted by Scott Coyle#Cellbio2025 come see the latest from the lab, including on opto/thermogenetics, condensates, RTK fusions, stress granules, biosensors of clustering. Talks and posters today and tomorrow!
- Reposted by Scott CoyleCome work with us! We are looking for a postdoc in #philbio or #philphysics to work on an interdisciplinary project that adopts the lens of self-organization & active matter to explore the boundary between living & nonliving systems www.kuleuven.be/personeel/jo... #academicsky #philjobs #HPS #evosky
- Reposted by Scott CoyleCells can hunt prey, solve mazes, and learn from past experience. Does this mean they can think, at some level? Find out more at our upcoming session on "Cell Behavior and Cognition" at the ASCB/EMBO #cellbio2025 meeting, Saturday 1-3 pm rm 115.
- Reposted by Scott CoyleSo happy to announce our new preprint, “A geothermal amoeba sets a new upper temperature limit for eukaryotes.” We cultured a novel amoeba from Lassen Volcanic NP (CA, USA) that divides at 63°C (145°F) 🔥 - a new record for euk growth! #protistsonsky 🧵
- Reposted by Scott CoyleOur new preprint describes Plasmodium NEK4 as a key regulator coupling meiotic initiation and morphogenesis—a critical step for malaria transmission. This involves MTOC-driven nuclear movement strikingly analogous to "horsetail" movement in fission yeast. www.biorxiv.org/content/10.1...
- Reposted by Scott CoyleWow! Remarkably complete story on the logic of phenotypic plasticity in a predatory protist - congrats @cellraiser.bsky.social et al!
- How do cells adapt morphology to function? In a 🔥 preprint by @zjmaggiexu.bsky.social , with @dudinlab.bsky.social and @amyweeks.bsky.social , we identify a self-organizing single-cell morphology circuit that optimizes the feeding trap structure of the suctorian P. collini. 🧵 tinyurl.com/4k8nv926
- Reposted by Scott CoyleThrilled to share our work on the 🔥 single-celled predator Podophrya collini, which rewires its cell morphology to hunt more efficiently. Huge thanks to our amazing team—Amy, Lauren, Omaya, Marine, Mari, and especially Scott—for making this shine! ✨
- How do cells adapt morphology to function? In a 🔥 preprint by @zjmaggiexu.bsky.social , with @dudinlab.bsky.social and @amyweeks.bsky.social , we identify a self-organizing single-cell morphology circuit that optimizes the feeding trap structure of the suctorian P. collini. 🧵 tinyurl.com/4k8nv926
- Reposted by Scott CoyleVery happy to see this out there ! Amazing work by @zjmaggiexu.bsky.social @amyweeks.bsky.social & @cellraiser.bsky.social! All #ProtistsOnSky are amazing, but when I bumbed into @zjmaggiexu.bsky.social & her poster 2y ago at a #GRC conference, I got the urge to attempt #ExpnasionMicroscopy! n/1
- How do cells adapt morphology to function? In a 🔥 preprint by @zjmaggiexu.bsky.social , with @dudinlab.bsky.social and @amyweeks.bsky.social , we identify a self-organizing single-cell morphology circuit that optimizes the feeding trap structure of the suctorian P. collini. 🧵 tinyurl.com/4k8nv926
- How do cells adapt morphology to function? In a 🔥 preprint by @zjmaggiexu.bsky.social , with @dudinlab.bsky.social and @amyweeks.bsky.social , we identify a self-organizing single-cell morphology circuit that optimizes the feeding trap structure of the suctorian P. collini. 🧵 tinyurl.com/4k8nv926
- Cellular structure self-organizes through an interplay between internal mechanisms and external cues. The single-celled suctorian P. collini builds a trap structure to capture large prey using microtubule feeding tentacles, creating feedback between cell morphology and prey availability.
- We found that P. collini traps display a broad range of morphological configurations: tentacle numbers from 1-25; and tentacle lengths ~15-30 um. To study this variation systematically, we built a deep-learning pipeline and suctorian-viewer app that digitizes the 3D morphology of P. collini cells.
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View full threadFinally – there are many mysteries to still resolve for these cells. From dramatic metamorphic capabilities🤯 to prey preference and detection mechanisms 🕵️. For anyone interested in collaborating or getting their hands on these cells, these fantastic beasts culture well and we’re happy to share!
- Reposted by Scott CoyleWe’re hiring! 🚨 Assistant Professor (TT) in Theoretical or Computational Biological Physics @univmiami.bsky.social 😀 Come build the future of interdisciplinary biophysics with us! Apply by Dec 15 → tinyurl.com/5n9bk836 #Biophysics #PhysicsJobs #AcademicJobs #UMiami
- Reposted by Scott Coyle🚨Our collaboration with @centriolelab.bsky.social & @gautamdey.bsky.social is out today in @cp-cell.bsky.social We show that #Expansion #Microscopy is a broad-spectrum modality for Euks, enabling 3D phenotypic maps rooted to phylogeny. #ProtistsOnSky #SciComm #SciSky www.cell.com/cell/fulltex...
- Reposted by Scott CoyleWhat's creepy and chemistry? Look back at this gallium-based liquid metal that squirms due to an electron-transfer reaction that changes the surface tension of the alloy.⚡ Researchers are investigating the serpentine locomotion of liquid metals for potential applications in soft electronics. [1/2]
- Reposted by Scott CoyleAn intimate conversation about what drives me every day in “sharing experience” of science by getting tools of science in hands of kids everywhere. themicroscopists.bitesizebio.com/episodes/man...
- Manu Prakesh ($1 #foldscope fame) guest stars on #TheMicroscopists. Quite incredible drive & desire for making science hands-on & accessible. He also talks about his passion for fieldwork, & explains why he has barnacles growing in his bathroom! Stream bit.ly/microscopist... @prakashlab.bsky.social
- Reposted by Scott CoyleBacteria use paralog teamwork to survive stress. H-NS forms fluid condensates; its partner StpA forms rigid fibrils. Together, they balance flexibility & stability to keep genes properly regulated under pressure. #PhaseSeparation #Bacteria www.biorxiv.org/content/10.1...
- Reposted by Scott CoyleAndrea A. Putnam, a UW School of Medicine and Public Health assistant professor of biomolecular chemistry, has been named a 2025 Packard Foundation Fellow in Science and Engineering. Congratulations, Dr. Putnam!
- Reposted by Scott CoyleFinal version of our paper on ciliary metachronal waves out now in Science Advances! doi.org/10.1126/scia... This is the main thesis work of my PhD student Rebecca Poon, who caught many #platnereis larvae and tirelessly ablated them with a laser. THREAD
- Reposted by Scott CoyleWe have PhD and Postdoc positions open in our group. Join us in Lausanne to explore how cells pull off extreme shape changes and how cilia drive biological flows. You can find more details on the projects available and how to apply in our website: www.epfl.ch/labs/lpl/joi...
- Reposted by Scott CoyleThe Institute of Science and Technology Austria (ISTA) @istaresearch.bsky.social is hiring a tenure-track staff scientist in Computational Structural Biology (cryo-EM, cryo-ET, structural prediction methods, image analysis)! More info here: apply.ista.ac.at/comp_structu...
- Reposted by Scott CoyleMCDB Assistant Professor Faculty Search. Please Repost! Applications Due Oct 15th (TOMORROW!) We welcome applications from all areas of physiology and neuroscience - spanning molecular, cellular, systems, and organismal levels. More information can be found HERE: lsa.umich.edu/mcdb/news-ev...
- Reposted by Scott Coyle#Expansion #Microscopy #Atlas of #Microbial #Eukaryotes is getting up to speed. We will be at full speed soon, but we are lucky to have a welcoming #protistology #community. Thx 🙏 to @Marine @fmikus.bsky.social @Julius & @Galina ⏭️Stop: @ccapoban.bsky.social #ExpandThemAll #ExAME #ProtistsOnSky
- Reposted by Scott CoyleExtremely excited to share that I’m joining Columbia University @columbiauniversity.bsky.social as an Assistant Professor! We will explore how the mobile genome works—how transposons shape us, our DNA and how they can be harnessed to build useful technologies. #NewPI #RNAsky #TEsky thawanilab.org
- Reposted by Scott CoyleSee this? This = implanting mouse embryo. Usually this happens inside its mother and is invisible to us, but we can actually watch implantation ex vivo with the hope of understanding why implantation goes awry in embryos of older women. A 🧵...
- Reposted by Scott CoyleHappy to share the inaugural paper from the lab. We describe a molecular mechanism for the activation of outer dynein arm motors that power the vital motion of cilia. Open access link below: www.nature.com/articles/s41... Here's a cool animated summary
- Reposted by Scott CoyleMammalian cells have KSR, budding yeast has Ste5… and fission yeast has Sms1 as the MAPK scaffold for sexual reproduction! Very excited to share my postdoc work where we discover that the hemi-arrestin Sms1 binds all components of the MAPK cascade, including ERK-like Spk1 doi.org/10.1101/2025...
- Reposted by Scott CoyleLove #protists? Then you'd love this! Beautiful collection of hand-drawn critters represented here at the Oxford-Japan symposium on ethological dynamics in diorama environments sites.google.com/view/oxford-... #ciliates #testateamoeba #diatoms
- Reposted by Scott CoyleI am excited to share our new preprint on the CAGE complex, a mysterious hollow protein complex that I first saw years ago while surveying Tetrahymena ciliary lysate www.biorxiv.org/content/10.1... #cilia #protistsonsky 🧬🧪
- Reposted by Scott Coyle🚀 Our new paper is out @natmethods.nature.com! Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells. 🔗 www.nature.com/articles/s41... 🧬 www.addgene.org/John_Ngo/
- Reposted by Scott CoyleA tremendous honor! Thrilled & humbled to receive 2025 Keio Medical Science Prize for launching LLPS #phaseseparation field (= #softmatter + #cellbio) w collaborators esp @HymanLab. & Congrats to Akiko Iwasaki @virusesimmunity.bsky.social. www.princeton.edu/news/2025/09... #KeioMedicalSciencePrize
- Reposted by Scott CoyleLooks like I am late to this party but have exciting news. I’ve been awarded an ERC Starting Grant to study #XtrmCells! Thankful to @erc.europa.eus for this opportunity, and to my collaborators, mentors, and group for their support. Looking forward to exploring the mechanics of these cells!
- Reposted by Scott CoyleSCHEPHERD--the bioelectric cell herding platform built for YOU. Single cells, monolayers, organoids--this herds them all + new tricks. Plz try it-- we will *give* you parts! Teaser here of a steering a single cell. GS Yubin Lin's lifeblood with J. Yodh on piano; Celeste R. and Paul K. Thread 1/N
- Reposted by Scott CoyleCongratulations to EMBO Young Investigator Uri Ben-David from Tel Aviv University, who has been named one of the 2025 Schmidt Polymaths by @schmidtsciences.bsky.social! 🧪 Uri will study human #aging through the lens of chromosomes. www.schmidtsciences.org/eight-scient... #award #genetics #GeneSky
- Reposted by Scott CoyleMy MCDB dept is accepting applications for a faculty position at the Assistant Professor level! Applications Due by October 15, 2025 We welcome applications from all areas of physiology and neuroscience, spanning molecular, cellular, systems, and organismal levels. lsa.umich.edu/mcdb/news-ev...
- Reposted by Scott CoyleWelcome to Bryce LaFoya, who joins the UW–Madison Department of Biochemistry this month as an assistant professor! Learn more about his research, interests, and lab: biochem.wisc.edu/2025/08/21/n...
