Bungo Akiyoshi
Studying kinetochores in African trypanosome (kinetoplastid) and marine plankton (diplonemid) in Edinburgh
ed.ac.uk/biology/groups/akiyoshi
- Reposted by Bungo AkiyoshiRestoring Shugoshin 1 reduces chromosome errors in human eggs biorxiv.org/content/10.64898/20…
- Next generation open access?? www.jisc.ac.uk/news/all/lan...
- Reposted by Bungo AkiyoshiWhat's it like being Editor-in-chief of @jcellsci.bsky.social? doi.org/10.1242/jcs....
- The discovery of the first kinetochore proteins (CENP-A, CENP-B, CENP-C) was reported by Bill Earnshaw and Naomi Rothfield in 1985 in Chromosoma. Forty years later, Chromosoma/Chromosome Research has published a special issue (most articles are open access) link.springer.com/collections/...
- Put together by Simona Giunta, @tatsuofukagawa.bsky.social, @roneilllab.bsky.social and myself. Big thanks to all the authors who contributed to this collection! link.springer.com/article/10.1...
- Reposted by Bungo AkiyoshiThanks @jcellsci.bsky.social for this opportunity to contribute to your centenary collection with our take on the state of the field - 10 years after its modern reincarnation 🧪🌍 W/ @alebenoit.bsky.social @eelcotromer.bsky.social @fritzlaylin.bsky.social journals.biologists.com/jcs/article/...
- Reposted by Bungo AkiyoshiDelighted to share our latest preprint on reverse gyrase, a unique topoisomerase found exclusively in thermophiles! www.biorxiv.org/content/10.6...
- Mitosis is beautiful
- Yes, this experiment says a lot...
- Self-citations are not elegant, yet I feel that much of what we need to know about the robustness of "LLPS scaffolds" is summarized in this figure doi.org/10.1016/j.mo...
- Reposted by Bungo AkiyoshiSelf-citations are not elegant, yet I feel that much of what we need to know about the robustness of "LLPS scaffolds" is summarized in this figure doi.org/10.1016/j.mo...
- Reposted by Bungo Akiyoshi#Diplonemids are among the most diverse & abundant #protists in the deep #ocean. This study localises >5,000 proteins of #Paradiplonema papillatum, revealing #organelle compartmentalisation, including a membrane coated with carbohydrate-degrading enzymes @plosbiology.org 🧪 plos.io/3XvmpIO
- Reposted by Bungo Akiyoshiwhether you agree with Andrea or not, what he is doing is very important for a healthy scientific culture. Thank you @andrea-musacchio.bsky.social for setting a great example for all of us: Speak your mind even if it is against the mainstream flow.
- There is always pseudoscience out there some of which are excellent at gaining momentum (and people, money, power) because they sound attractive. But pseudoscience is pseudoscience. Time will tell. As a scientist, one should judge what's right/wrong by themselves
- Reposted by Bungo Akiyoshi[This post could not be retrieved]
- Reposted by Bungo Akiyoshi[This post could not be retrieved]
- Reposted by Bungo Akiyoshi[This post could not be retrieved]
- Reposted by Bungo AkiyoshiSo happy to announce our new preprint, “A geothermal amoeba sets a new upper temperature limit for eukaryotes.” We cultured a novel amoeba from Lassen Volcanic NP (CA, USA) that divides at 63°C (145°F) 🔥 - a new record for euk growth! #protistsonsky 🧵
- Reposted by Bungo AkiyoshiA new and fascinating story from @bencarty.bsky.social and the group, with crucial help from the teams of @naltemose.bsky.social, Simona Giunta, and @dfachinetti.bsky.social. Many thanks to all for a fantastic collaboration. www.nature.com/articles/s41...
- Reposted by Bungo AkiyoshiI however wonder why a new supergroup was erected (Disparia) when the existing supergroup Promethea precisely describes this grouping? Promethea was published here: www.cell.com/iscience/ful...
- Reposted by Bungo AkiyoshiWhy IDPs Are Poor Candidates for Homotypic LLPS 🧵👇A thread
- Reposted by Bungo AkiyoshiWhy LLPS Scaffolds Cannot Exist – A Thermodynamic Thread If you consider arguments logical, please share. Else please expose logical faults 🧵👇
- Trypanosoma
- Reposted by Bungo Akiyoshi[This post could not be retrieved]
- Reposted by Bungo AkiyoshiDeadline 18th Nov! Please write to express your support for continued funding for Jalview!
- I just found this now. @jalview.bsky.social team needs your support for their BBSRC application. Deadline tomorrow! discourse.jalview.org/t/write-a-le...
- I just found this now. @jalview.bsky.social team needs your support for their BBSRC application. Deadline tomorrow! discourse.jalview.org/t/write-a-le...
- Reposted by Bungo Akiyoshi[This post could not be retrieved]
- Reposted by Bungo AkiyoshiRadiolarian - a huge one!
- Reposted by Bungo AkiyoshiIt’s a beautiful afternoon. Dive 3 (864). We are taking Subastian into a deep underwater canyon. Live feed will begin soon: www.youtube.com/@SchmidtOcea...
- Interested in pursuing a PhD by working on a long-neglected marine organism and making a lot of discoveries? Darwin Trust offers a PhD studentship for international students (anyone non-UK) www.findaphd.com/phds/project...
- My attempt to become a professor was unsuccessful again but the diplonema tagging paper is now published in Open Biology. royalsocietypublishing.org/doi/10.1098/...
- Reposted by Bungo Akiyoshi
- Simply looking at the 60 pages of images is just so much fun. Data S1 console.s3.embl.de/browser/cult...
- 🚨Our collaboration with @centriolelab.bsky.social & @gautamdey.bsky.social is out today in @cp-cell.bsky.social We show that #Expansion #Microscopy is a broad-spectrum modality for Euks, enabling 3D phenotypic maps rooted to phylogeny. #ProtistsOnSky #SciComm #SciSky www.cell.com/cell/fulltex...
- Reposted by Bungo AkiyoshiOnly the second radiolarian I’ve seen in my life, and this one is a chonks! #marineplankton #protistsonsky 🦑
- I was happy with the cell counter which worked for more than 10 years. When I bought a new one recently, the company sent a newer version, which turned out to be an absolute nightmare
- Reposted by Bungo AkiyoshiBéla Novák (1956–2025) – a legacy of scientific discovery and personal charm Alexis Barr, Francis Barr and John Tyson remember Béla Novák. journals.biologists.com/jcs/article/...
- Reposted by Bungo AkiyoshiWe have a 3+ year post doc available in our lab to study trypanosome transmission and virulence. Combined wet lab and bioinformatics expertise preferred. Please apply via the HR link (elxw.fa.em3.oraclecloud.com/hcmUI/Candid...). Find out more about us in the link below.
- Reposted by Bungo AkiyoshiHHMI adopts Plan U journals.plos.org/plosbiology/...
- Congrats to all authors, especially Lim who had an impressive PhD viva last week! TAC is a very interesting structure linking mitochondrial DNA and basal bodies in trypanosomes
- The trypanosomal TAC of is required for mitochondrial DNA segregation: Discovery of the novel TAC53 subunit and the tubular arrangement of the TAC filaments Joint study by the Ochsenreiter and Schneiderlabs. 👏 to 1. Author Lim. journals.plos.org/plospathogen... #mitochondria #mtDNA #Trypanosoma
- Reposted by Bungo AkiyoshiSave the dates!! @bspparasitology.bsky.social Spring Meeting 2026 will be in Bonnie Glasgow! 7-9 April 2026, with a drinks reception in Glasgow City Chambers on the 6th of April 2026! Keep an eye on the BSP website for registration and abstract submission! Logo by @shannaraeilean.bsky.social! 🦟
- Reposted by Bungo AkiyoshiA big welcome to everyone who has joined us for the @bspparasitology.bsky.social trypanosomiasis and leishmaniasis meeting this week in the beautiful city of Ceske Budějovice!
- I guess I have been quite open about my ongoing diplonema project, showing PCR results, live cell imaging, IF attempts, some interesting localization. For example, my tweet about "one of two flagella" protein led to conversations with various people I had not talked to. It's been so much fun
- But I do not tweet about lab members' progress on trypanosome work because they may get annoyed
- Core funding, Orbitrap Astral, Aquilos 2, super low facility charges, etc etc
- Reposted by Bungo AkiyoshiBuilding a synthetic cell together - nice common perspective written by many leading scientists who gathered in Shenzhen China for the inaugural ‘SynCell Global Summit’. Check it out in Nature Comm: www.nature.com/articles/s41...
- Hotel ISG, EMBL
- In Tokyo last month. In Heidelberg this week. Let's see what kind of images we can get
- Reposted by Bungo AkiyoshiWant to acquire #ExM images like this and help us understand the true extent of cytoskeletal diversity across the tree of life? This position might be for you! embl.wd103.myworkdayjobs.com/en-US/EMBL/j... With @dudinlab.bsky.social @embl.org @biology-unige.bsky.social @moorefound.bsky.social
- My attempt to become a professor was unsuccessful again but the diplonema tagging paper is now published in Open Biology. royalsocietypublishing.org/doi/10.1098/...
- I am happy to share a preprint on the marine plankton project I started one year ago (thanks to Julius and Drahomira's help) www.biorxiv.org/content/10.1...
- Reposted by Bungo AkiyoshiThe discovery of CENP-A, the centromere-specific histone H3 variant turns 40 years! Grant Rowley wrote a wonderful historical piece on the cell cycle control of this fascinating piece of chromatin! Check it out. link.springer.com/article/10.1...
- Reposted by Bungo Akiyoshi📣 Open postdoc position in my lab to investigate how Toxoplasma acquires nutrients. Join me at the University of Edinburgh. Closing date 14th August. More details below ⬇️ elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
- Reposted by Bungo AkiyoshiNew preprint! We solve a mystery you didn't know existed. Mitotic cells lack new transcription but require ongoing translation. Interphase mRNA half life is only 2-4 hrs. So how do cells arrest in mitosis for hours without depleting their transcriptomes? www.biorxiv.org/content/10.1...
- Reposted by Bungo AkiyoshiSubcellular proteomics of Paradiplonema papillatum reveals digestive capacity of the cell membrane and the plasticity of peroxisomes across euglenozoans biorxiv.org/content/10.1101/202…
- The problem is that the more I understand, the less it makes sense. Something is not right
- We all make assumptions based on existing knowledge. My assumptions when studying mitosis are - Cells divide sister chromatids - Cohesin holds sisters together - Kinetochores interact with spindle microtubules I feel that at least one assumption is not valid in diplonemids. I am confused
- A lesson I learned from studying unconventional trypanosome kinetochores is that it's better not to make much assumptions, but I thought that the very basic assumptions as above should apply to any eukaryote. Non-traditional eukaryotes are so interesting
- Reposted by Bungo AkiyoshiAfter 5 amazing years @pilhoferlab.bsky.social I'm starting my lab @embl.org Grenoble this November embl.org/wollweber We'll image Asgard archaea and many other strange microbes ( #archaeasky, #protistsonsky..) to understand eukaryogenesis First job ad: #teamtomo scientist!🔬❄️ tinyurl.com/2rdu2ze6
- Reposted by Bungo AkiyoshiPostdoc positions open in my lab (Francis Crick Institute) to study 1. initiation of DNA replication. 2. chromatin replication/epigenetic inheritance. Great for biochemists, biophysicists and cryo-EM/cryo-tomography scientists. Deadline 3 August 2025. crick.wd3.myworkdayjobs.com/External/job...
- Reposted by Bungo AkiyoshiCelebrating 25 years of curiosity, kinetochores, and cutting-edge science! Congratulations to the @suebiggins.bsky.social Lab @fredhutch.bsky.social on their 25th anniversary. Cheers to all the amazing colleagues that have made it such a wonderful place to do research over its past and present!
- Happy 25th anniversary, Biggins lab! @suebiggins.bsky.social
- Thanks for your feedback. Most people "never thought about that before", which is exactly why I wanted to write this paper. But yes, it is Garg and Martin who first proposed the idea. I reached the same idea independently from a different angle
- I loved reading this paper, need to read Garg and Martin next apparently. Maybe LECA was doing something like parasex??? en.wikipedia.org/wiki/Parasex... In any case, after reading your article, I am firmly in team Meiosis First. Never thought about that before!
- Reposted by Bungo AkiyoshiIn this Hypothesis article, Bungo Akiyoshi @bungoakiyoshi.bsky.social proposes that key aspects of meiosis evolved prior to mitosis in ancestral eukaryotes. journals.biologists.com/jcs/article/... bsky.app/profile/bung...
- Reposted by Bungo AkiyoshiSomething a bit different from the Gruber lab: More than 10 years ago, we (and others) tried to linearize the B. subtilis chromosome using a phage telomere (successfully used before in E. coli). But it did not work.
- It is great to see lab members making discoveries based on their own idea, which get them more excited and become independent (so that I can spend more time on my own project)
- Reposted by Bungo AkiyoshiCheck out this month’s #ISOP Member Spotlight featuring Patrick Keeling! We discuss the major challenges facing science today, the importance of storytelling in protistology, and Patrick’s experience with his long-running undergraduate protistology course at UBC #ProtistsOnSky
- Published now. doi.org/10.1242/jcs....
- Reposted by Bungo Akiyoshi90% of you probably don’t need to read this. But maybe some of you are curious & 10% will feel seen. Or a little less alone. This isn’t about seeking sympathy. It’s about sharing something hard to say out loud; partly to heal, partly in case someone needs to hear it too. (1/3) tinyurl.com/DudinO
- Reposted by Bungo AkiyoshiThe tripartite attachment complex (TAC) of Trypanosoma brucei is required for mitochondrial DNA segregation. Want to know how its outer membrane part is assembled? Check out our new preprint www.biorxiv.org/content/10.1...
- Dynamic cell (Paradiplonema papillatum)
- Dynamic chromosomes
- Swimming cells
- I thought it's perilla leaf (しそ)
- Reposted by Bungo AkiyoshiNon-profit journals are on the critical list. The cause: academics obsession with the Nature brand, coupled with the APC $ model. Some will argue it doesn’t matter (“all as bad as each other”). But the fact is undeniable and it’s good guys who put money back into science like COB who are losing..
- Thanks @mitodynamics.bsky.social for the fun interview and for saying it like it is: “…JCS and other community journals are being crushed by the mega profit-making journals, which just seem to proliferate and spit out new journals by the day…we must all make an effort to move away from this…”
- Reposted by Bungo Akiyoshi
- Reposted by Bungo AkiyoshiPlease consider applying for a post doc in our lab if you have bioinformatics and wet lab skills, and are interested in parasites! elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
- Reposted by Bungo AkiyoshiWow: check it out; these fungi distribute their chromosomes across different nuclei! Normally each nucleus has a complete set of all chromosomes. Distribution of haploid chromosomes into separate nuclei in two pathogenic fungi | Science www.science.org/doi/10.1126/...
- Reposted by Bungo AkiyoshiBeyond a Linear Structure: The Tubular Organization of the Tripartite Attachment Complex and the Functional Role of TAC53 biorxiv.org/content/10.1101/202…
- Reposted by Bungo AkiyoshiIf the topology of the tree changes every time a new lineage is discovered or someone else picks their favorite protein markers and runs a tree, maybe it’s time to take a step back and wait a bit. This is not against this particular paper but it’s a general grievance I have with the field right now.
- My first immunofluorescence attempt for Paradiplonema papillatum
- Reposted by Bungo AkiyoshiDeep origin of eukaryotes outside Heimdallarchaeia within Asgardarchaeota www.nature.com/articles/s41...
- From Andreas Houben's group. Looks very interesting.
- Kinetochore mutations and histone phosphorylation pattern changes preceded holo- and macro-monocentromere evolution biorxiv.org/content/10.1101/202…
- Reposted by Bungo AkiyoshiNew paper out! We discovered a tiny archaeon with the smallest known archaeal genome — only 238 kbp! Candidatus Sukunaarchaeum mirabile has almost no recognizable metabolic pathways and may rely heavily on a host to survive. It also represents a novel, deep-branching lineage in the archaeal tree.
- Reposted by Bungo AkiyoshiTwo CENH3 paralogs in the green alga Chlamydomonas reinhardtii have a redundantly essential function and associate with ZeppL-LINE1 elements onlinelibrary.wiley.com/doi/10.1111/... beautiful insights into the Chlamy LINE-based centromeres from the Umen and Dawe groups @corncolors.bsky.social
