Brain
Brain has published landmark papers in clinical neurology and translational neuroscience since 1878.
- Cardoso et al. review the conditions collectively termed Huntington’s disease phenocopies, in which Huntington’s disease is suspected but no HTT mutation is found. They discuss clinical features and underlying aetiologies with an emphasis on acquired causes. shorturl.at/qqYFE
- Benina et al. evaluated the plasma pTau217/Aβ 1-42 ratio as a blood-based marker of AD pathology. The ratio improved diagnostic accuracy and reduced indeterminate results vs pTau217 alone, supporting its clinical utility for identifying amyloid positivity. shorturl.at/qBUS1
- Over 125 years ago, Cécile & Oskar Vogt began assembling an extensive collection of brain histological sections and related documents. Katrin Amunts explores how digitizing these materials will create a valuable resource for modern neuroscience. shorturl.at/RaMw8
- Vermorgen et al. examine tau aggregation in astrocytes in brains from middle-aged adults. They show that ARTAG (ageing-related tau astrogliopathy) is not restricted to elderly brains and is associated with neurodegenerative pathology. shorturl.at/NEYWB
- Tsang et al. reviewed 13 studies combining TMS with intracranial EEG in humans and non-human primates. They found that stimulation can rapidly alter neuronal activity and connectivity, with some effects persisting for extended periods. tinyurl.com/yver3s93
- The January 2026 issue of Brain is now online! academic.oup.com/brain/issue/...
- Reposted by BrainHave you read an outstanding paper published in Brain Communications during 2025? Take note of it for the Early Career Researcher Paper Prize! Nominations are Open! #ecr #paperprize #neuroscience Link to form: buff.ly/8DWT8TV Find out more at: buff.ly/5WfBuCR
- González-Velasco et al. show that somatic mutations in known ALS genes are enriched in the motor cortex of patients with sporadic ALS, particularly in excitatory neurons, and may contribute to disease initiation. tinyurl.com/24vx7shp
- Multiple studies have shown a mismatch between EEG parameters and subjective sleep quality. Hauglund & Nedergaard argue that nightly clearance of brain waste via the glymphatic system may be crucial for the restorative properties of sleep. tinyurl.com/2ju4cyc6
- Defining neurological disease is less objective than often assumed. Simon Shorvon considers how confusion between symptoms and disease, shifting criteria, unstable classifications, and complex aetiology can undermine the medical model. tinyurl.com/5n8anfsc
- Although new Alzheimer's disease therapies reduce amyloid plaques, they have not led to major clinical improvements. Pini et al. suggest that changes in brain connectivity may offer a more sensitive and biologically meaningful marker of disease modification. tinyurl.com/32975se3
- Thalamic highways as a bridge to neuromodulation New scientific commentary by David Burdette, Bahram Sarvi Zargar & Paul Ferrari tinyurl.com/bdhh28dn
- White matter changes in Alzheimer's disease: contributor, consequence or co-pathology? New scientific commentary by Julia Neitzel tinyurl.com/3x5ezsrc
- December's issue of Brain is now online! academic.oup.com/brain/issue/...
- One third of stroke survivors experience vision loss. Raffin et al. present a non-invasive brain stimulation technique targeting visual pathways and show that it improves perception and expands visual fields. tinyurl.com/yhppvzkv
- De Marchi et al. used FDG-PET and machine learning to examine neuropsychological and metabolic differences across the ALS-FTD spectrum, revealing distinct cognitive profiles and patterns of brain hypometabolism.
- Koch et al. review motor skill learning and sensorimotor adaptation after stroke, highlighting ways in which lesion location, recovery stage, and individual differences affect learning, and offering recommendations for future research.
- Weisman et al. critically examine the claim that pain can exist purely in the mind, without any physical trigger in the body, arguing instead that nociception is necessary – but not sufficient – for pain. tinyurl.com/yw88waba
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- Cortical cerebral microinfarcts spark cognitive decline New scientific commentary by Gemma Solé-Guardia, Anil Tuladhar & Frank-Erik de Leeuw: tinyurl.com/nhrr7fek
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- Choo et al. show that damage to the medial temporal lobe – particularly the hippocampus – reduces the precision of memory for fine visual details, underscoring the role of this region in maintaining the fidelity of visual working memory representations. tinyurl.com/t2jxztz7
- November's issue of Brain is now online! academic.oup.com/brain/issue/...
- Mukherjee et al. review how ageing affects remyelination in MS. While most studies suggest remyelination capacity decreases with age, findings are sometimes inconsistent, and remyelination remains possible at any age. tinyurl.com/c2ynpfrj
- Togo et al. show strong electrophysiological links between the hippocampus and both the anterior and posterior thalamus, along with robust connections between thalamic subregions. tinyurl.com/5c6n23xj
- Kollenburg et al. review the molecular mechanisms and regional activity patterns underlying headache disorders including migraine, cluster headache, and paroxysmal hemicrania. tinyurl.com/46aafjxu
- Reposted by BrainThe current environment is making it near impossible to run clinical trials in the UK. One key issue discussed in @brain1878.bsky.social is the duplication - or worse - of regulatory oversight at NHS hospitals & universities. My views on how to change the system academic.oup.com/brain/articl...
- Pruckner et al. show that the structural effects of neurosurgery extend beyond the resected tissue into connected networks through transneuronal degeneration. They were able to reliably predict these changes from preoperative MRI. tinyurl.com/a6rxvbey
- New issue of Brain now online! tinyurl.com/mwxp6x24
- Avalos-Alais et al. present a high-resolution probabilistic map of bidirectional effective connectivity between the human lateral PFC and widespread cortical and subcortical regions, based on analysis of intracranial evoked potentials. tinyurl.com/br7htec9
- Mongay-Ochoa et al. review advanced methods for mapping brain connections and identify common topographical patterns of pathology spread across different neurological disorders, including MS, AD and PD. tinyurl.com/3sz8ayup
- Research into mental imagery often relies on Hume’s view of visual imagination as weak perception. Arcangeli & Bartolomeo argue that Sartre’s alternative framework – supported by recent findings on aphantasia – offers a more conceptually robust approach. tinyurl.com/n2k3md9e
- Pansieri et al. argue that bureaucracy is suffocating research, as an ever increasing admin burden consumes researchers’ time and diverts focus from discovery to compliance. tinyurl.com/ybv5e9ft
- Using tau PET and post-mortem data from individuals with five clinical variants of AD, de Bruin et al. show that tau progression follows the brain’s intrinsic functional connectivity architecture, originating from local epicentres. tinyurl.com/bdfprjcn
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- September's issue of Brain is now online! academic.oup.com/brain/issue/...
- Abreaction was once a common treatment for functional neurological disorder (FND) but has since fallen out of use. Norman Poole argues that abreaction is compatible with many findings from modern neuroscience, and should be tested as a treatment for FND. tinyurl.com/fcjpywx2
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- From signal to senescence: IFNγ drives muscle atrophy in myositis New scientific commentary by Werner Stenzel et al. tinyurl.com/33hwhd8f
- Arena et al. show that a history of TBI or repetitive head impacts from contact sports is associated with widespread tau pathology within glial cells, beyond that of chronic traumatic encephalopathy. tinyurl.com/h658b3f2
- August's issue of Brain is now online! academic.oup.com/brain/issue/...
- Yogeshwar et al. present clinical and MRI data from 127 patients with anti-IgLON5 disease. They show brain atrophy patterns that closely mirror sites of autoantibody binding and tau accumulation, with the location of atrophy linked to specific symptoms. tinyurl.com/3u4ufv2z
- Peruzzotti-Jametti et al. examine the remyelination potential of mouse- and human-derived directly induced neural stem cell (iNSC) grafts, and show that iNSCs can differentiate into mature oligodendrocytes and remyelinate axons in demyelinated lesions. tinyurl.com/3a2auah5
- Disentangling epilepsy and dementia: more to do, together New scientific commentary by Arjune Sen tinyurl.com/mr44jt9b
- Reposted by BrainI’m delighted to share my editorial for the July issue @brain1878.bsky.social academic.oup.com/brain/articl...
- Benninger & Goldberg argue that early surgery for lesional focal epilepsy should be considered even before the emergence of drug resistance. tinyurl.com/3b7msy45
- Medial temporal lobe structural changes when Down syndrome and Alzheimer’s disease collide New scientific commentary by Laura Wisse and Renaud La Joie tinyurl.com/345u5r3w
- The converging paths to hippocampal sclerosis of ageing: insights from LATE-NC and vascular disease New scientific commentary by Ryan Coburn and Hugo Botha tinyurl.com/3ffhrkm7
- Kazazian et al. review the use of neuroimaging in disorders of consciousness, detailing key methods (fMRI, EEG, PET) and imaging paradigms that can be used to improve diagnosis and prognosis. tinyurl.com/bddyanm4
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- Benninger & Goldberg argue that early surgery for lesional focal epilepsy should be considered even before the emergence of drug resistance. tinyurl.com/3b7msy45
- Proelss et al. describe the mapping of human genital representations by electrical stimulation of somatosensory cortex. Males but not females report genital sensations in response to stimulation of the postcentral gyrus. tinyurl.com/2xptrtfs
- Moschovaki-Filippidou et al. show that an exon skipping morpholino targeting Dnm2 splicing reduces intact Dmn2 mRNA and protein levels in muscle, and restores muscle force, in a centronuclear myopathy mouse model. tinyurl.com/3hth9csf
- Graham et al. used biomarkers to investigate the effects of TBI in mid-life former elite rugby players. Compared to unexposed controls, these individuals showed elevated plasma p-tau217 levels and reduced volumes in frontal and anterior cingulate cortex. tinyurl.com/j8emw6d3
- Pathogenic variants in CLCN3 and CLCN4—which encode the 2Cl-/H+ exchangers ClC-3 and ClC-4—cause rare neurodevelopmental disorders. Qi et al. show that ClC-3/ClC-4 regulate neuronal excitability and firing patterns by fine-tuning Kv7/KCNQ channel density. tinyurl.com/2tbpdevh
- July's issue of Brain is now online! academic.oup.com/brain/issue/...
- TDP-43 aggregates play a key role in nerve cell loss in ALS and FTD. Ervilha Pereira et al. highlight new genetic data showing that TDP-43 also plays a role in muscle function and disease. tinyurl.com/2uy95axn
- Sun et al. generate a transcriptomic map of the developing human leptomeninges by analysing more than 27 000 single-cell transcriptomes from tissues spanning different fetal stages. tinyurl.com/3z7cj7pc
