Ben Nicolet
Postdoc @ Schumacher lab, immunology, ML, TCR, Amsterdam
- Can you boost the protein expression in specific cell types? That is what we asked in our study published a week ago in @scienceadvances We used machine learning (AI) to learn the code for protein expression in immune cells. www.science.org/doi/10.1126/...
- Then we used that knowledge to boost or dampen the expression of different proteins. There are many exciting applications!! e.g. enhance (protein) drug production, enhance mRNA expression in vaccines, boost T cell immunotherapy efficacy…
- Very proud of our team @sanquin & @oncodeinstitute.bsky.social (yet now im at @nkinl.bsky.social ) and especially my mentor @monikawolkers.bsky.social
- Reposted by Ben Nicoletit is finally out! 👇 our #ML pipeline SONAR, which can predict the protein abundance in #immune cells. Using sequence features present in the #RNA. With @bnicolet.bsky.social Supported by the @erc.europa.eu and@oncodeinstitute.bsky.social www.science.org/doi/epdf/10....
- Reposted by Ben NicoletIt's not the models, it's the data! We show that a substantial proportion of a widely used TCR-pMHC database does not functionally validate, causing underestimation of performance of TCR-pMHC prediction models. www.biorxiv.org/content/10.1...
- Getting inspired at the EMBL sustainability event!
- Super grateful and happy to be part of MATCHMAKERS team of @cancergrand.bsky.social : bit.ly/4iN1dY9 (And thanks to CGC for the opportunity to talk about my work!)
- Super grateful and happy to be part of MATCHMAKERS team of @cancergrand.bsky.social : bit.ly/4iN1dY9 (And thanks to CGC for the oppressed to talk about my work!)
- Damn you autocorrect oppressed = opportunity. Sorry
- Reposted by Ben Nicolet
- New preprint 📣📣 Together with Monika Wolker's lab @sanquin Amsterdam, we optimized a smFISH protocol for T cells. We measured cytokines IFNG/TNF expression and localization during T cell activation and optimized an imaging pipeline for quantification. www.biorxiv.org/content/10.1...
- (Repost from EMBO on x) Rethinking #sustainability in #science: read about three projects on consumption and waste of shortlisted candidates for the EMBO Lab Sustainability Award embo.org/people/rethink… @CanigovaNikola @bnicolet.bsky.social @SELS_Network
- Reposted by Ben Nicolet
- Looking forward to attend this great meeting!
- Calling all T-cell aficionado's. Come and join us next year (27-28 May 2025) for the fourth Antwerp T-Cell Receptor conference organised by @pmeysman.bsky.social, @krislaukens.bsky.social and Benson Ogunjimi. I'll also be there! www.uantwerpen.be/en/conferenc... #ImmunoSky
- Reposted by Ben NicoletNew preprint 📣📣 Together with Monika Wolker's lab @sanquin Amsterdam, we optimized a smFISH protocol for T cells. We measured cytokines IFNG/TNF expression and localization during T cell activation and optimized an imaging pipeline for quantification. www.biorxiv.org/content/10.1...
- Reposted by Ben NicoletWonderful to see the #immunology community growing here. The first starter pack is full (they cap at 150), so I created a second one. Let me know if you'd like to be added go.bsky.app/PY5tCas go.bsky.app/FmERUoDat://did:plc:34vvwie7t4ys6zrcphjna2py/app.bsky.graph.starterpack/3l5hp62jg542w
