anna brogan
PhD student into bacteria & coffee. Rudner lab @harvardmed. @penn_state alum.
- Reposted by anna broganUnlike other #bacteria, C. difficile must detect both germinant & co-germinant signals to trigger #spore #germination. This study finds that the CspC:CspA complex is a key signaling node that integrates environmental cues to regulate #Cdifficile spore germination @plosbiology.org 🧪 plos.io/4rtCKdZ
- Reposted by anna broganGreat new story from Sophie Helaine and Molly Sargen! www.helainelab.com
- A prophage-encoded abortive infection protein preserves host and prophage spread www.nature.com/articles/s41...
- Fer’s tour de force in B. anthracis is out! Fer got Tn-seq running, built an ordered knockout library, defined all essential sporulation genes, and found a peptidoglycan deacetylase inhibitor critical for engulfment. Including our first one-by-all Alphafold screen! journals.plos.org/plosbiology/...
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- Reposted by anna broganThrilled to share that the final piece of my PhD work is now on bioRxiv! biorxiv.org/content/10.1... With support from @nvidia and the @NSF, we used AlphaFold to screen 1.6M+ protein pairs, revealing thousands of potential novel PPIs. All data can be viewed at predictomes.org/hp
- Reposted by anna broganIdentification of genetic interactions in Bacillus subtilis cell division. Congratulations, Byoung-Mo Koo, Carol Gross, and all involved! @cp-cellsystems.bsky.social #subtiwiki www.cell.com/cell-systems...
- Reposted by anna broganDual transposon sequencing profiles the genetic interaction landscape in bacteria | Science www.science.org/doi/10.1126/...
- Reposted by anna brogan#microsky We challenge the long-standing view that peptidoglycan alone protects cells from bursting. Our study shows that the periplasm — enclosed by OM–PG connections — acts as a pressure buffer essential for osmoprotection in Gram-negative bacteria. 📄 www.nature.com/articles/s41...
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- Very happy to share that a large part of my thesis work is out today: B. subtilis uses the second messenger c-di-AMP to modulate its turgor pressure in response to the state of its cell envelope. www.nature.com/articles/s41...
- c-di-AMP has long been implicated in resistance to cell wall targeting antibiotics. We hypothesized that there could be a regulatory connection between the cell envelope and c-di-AMP levels.
- Reposted by anna broganI’m excited that the work by Diego Ramirez and Lei Yin is out, where they gained several key insights into what provides the force underlying bacterial cell division doi.org/10.1101/2025.... To divide, cells must first bend the membrane inward, a process that’s energetically expensive
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- Reposted by anna broganVery excited to share that my thesis work is out in Molecular Cell! We trained a Structure and Omics informed Classifier (SPOC) to score binary AlphaFold multimer (AF-M) predictions by structural quality and consistency with experimental omics datasets. www.cell.com/molecular-ce...
- Reposted by anna broganSAVE THE DATE ‼️ 📆 📢 BBM 2025 will be held on June 9-10th at the Harvard Science Center feat. the one and only Dr. Petra Levin as keynote! We can't wait to see you there. Registration and scholarship applications open next week.
- Angelika Gründling’s work from her sabbatical in the Bernhardt-Rudner labs is out. She came with the goal of finding the missing G+ phosphatidylglycerol phosphate phosphatase and found it with time to spare. I can also highly recommend her as a bay mate! www.pnas.org/doi/10.1073/...
