We developed H&E-UTAG, an unsupervised method that detects recurrent microanatomical domains directly from H&E slides. It identified 218 domains across 40 tissues and 29 organs — revealing how cellular organization underlies organ function.

Among 100+ biological and clinical factors, age was the main driver of microanatomical changes. About 27% of domains shift in abundance over adulthood, yet others remain remarkably stable.