Very hot from the press !
Almost every topic we work in:
#IonChannels #Leukocytes #CalciumSignaling
T cell response depends on target-cell stifness to drive Piezo1- Orai1 membrane channels activation, softening of tumours prevents this response.
Full
www.science.org/doi/10.1126/... @science.org
T cell polarization and NFAT activation are stiffness dependent and differentially regulated by the channels PIEZO1 and ORAI1
Target stiffness influences T cell polarization and gene expression through distinct Ca2+ channels.
