Zhenyu Zhong
Assistant Professor at UT Southwestern Medical Center. We study inflammation, metabolic diseases, and cancer. Opinons are my own.
- Why is obesity often associated with dysregulated, low-grade chronic inflammation? In our new paper in @science.org we show that obesity rewires nucleotide metabolism in immune cells, making inflammatory responses much easier to trigger. www.science.org/doi/10.1126/...
- Macrophages from obese humans and mice show hyperactive NLRP3 inflammasome signaling, producing excess IL-1β relative to those from lean subjects.
- This is not due to increased expression of inflammasome components. Instead, obesity disables SAMHD1, an enzyme that normally restrains intracellular dNTP pools.
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View full threadGrateful to our wonderful collaborators and outstanding lab members👍 and for support from UTSW, CPRIT, and NIH🙏
