How do you deal with missing values and "unique" proteins that were only identified in one condition in proteomics data?
Mengchun Li, an amazing PhD student in my lab, developed this great Bayesian approach. Please try it and give feedback!
www.biorxiv.org/content/10.6...
Empirical-Bayes and Bayesian Hierarchical Modelling for Missingness and Differential Expression in Proteomics
Mass spectrometry-based label-free proteomics data often suffer from missing values, especially for low-abundance proteins or when a protein is completely absent in one condition. This makes it challe...
