Understanding bacteria's role in transforming steroids to pharmaceuticals
Paper: Journal of Biological Chemistry
Sal is a proteobacterial bile acid aldolase that repurposes key thiolase catalytic residues for retroaldol cleavage of C5 steroid side chains
doi.org/10.1016/j.jb...
Understanding bacteria's role in transforming steroids to pharmaceuticals
For decades, pharmaceutical companies have been using bacteria found in soil and water to chemically convert steroids into effective treatments for human diseases. One example is cortisol, which is us...
