Our paper on TadA-based cytosine base editors is now online in Advanced Science. We introduce zTadCBEs—a next-generation CRISPR base editor optimized for zebrafish.
advanced.onlinelibrary.wiley.com/doi/10.1002/...
By engineering TadA-based cytosine base editors with enhanced PAM flexibility and reduced off-targets, we overcome key limitations of existing CBEs, including poor editing at CC and GC motifs.
