This week in
#psychedelic science: A new
@natureportfolio.nature.com paper disentangles how psychedelics work at the 5-HT2A receptor. The study shows that Gi signaling drives hallucination-like effects, while Gq signaling underlies therapeutic outcomes.
Read the study:
Psychedelics elicit their effects by 5-HT2A receptor-mediated Gi signalling - Nature
Psychedelics and their non-hallucinogenic analogues were compared, revealing that serotonin 2A receptor (5-HT2AR)-mediated Gi signalling is essential for hallucinogenic effect, with the functional mec...
