Craig Kaplan: I love reading about how anti-phage systems work. This paper from the Laub lab shows RAZR system that forms a RING around phage proteins that form rings. www.nature.com/articles/s41...

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Craig Kaplan triggerloop.bsky.social
I love reading about how anti-phage systems work. This paper from the Laub lab shows RAZR system that forms a RING around phage proteins that form rings. www.nature.com/articles/s41...
Bacterial immune activation via supramolecular assembly with phage triggers - Nature

An antiphage defence system has an activation mechanism that relies on the sensing of phage-encoded proteins that enforce geometry crucial to activation and are not typically present in non-infec...

nature.com
Feb 5, 2026 02:09
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Craig Kaplan triggerloop.bsky.social · Feb 5
Here is ANOTHER one- this one uses its ring to form a pore after interacting with phage ring proteins. Whereas system above activates an RNA-degrading nuclease. From Norris and Maxwell labs www.nature.com/articles/s41...
A pore-forming antiphage defence is activated by oligomeric phage proteins - Nature

Bacteria use diverse defence systems against phages, including a 164-residue prophage-encoded protein, Rip1, which senses conserved phage assembly rings to form membrane pores that block virion matura...

nature.com

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