Using barcodes 📊 to track cancer 💊 resistance evolution: is it clonal selection or plasticity?
@fwhiting.bsky.social knows! His new "Evolutionary Informed Resistance Assays" (EIRAs) framework infers resistance evolution dynamics from barcode diversity data.
www.nature.com/articles/s41... @icr.ac.uk
Quantitative measurement of phenotype dynamics during cancer drug resistance evolution using genetic barcoding - Nature Communications
Understanding the dynamics of how drug resistance originates in cancer remains crucial, but it is not possible to observe them directly. Here, the authors construct a mathematical framework to infer d...
