Toth-Petroczy lab
Protein evolution, IDRs, bimolecular condensates, phenotypic mutations. Science and fun from the ATPlab.
- I am honored and proud to work with my amazing group @mpi-cbg.de and @csbdresden.bsky.social 🥰 🧬. Thanks to all my colleagues for the wonderful scientific environment. And thank you @kboes.bsky.social for preparing this superb video! 🤩
- Watch this video about the work of the research group of @agnestoth.bsky.social @mpi-cbg.de & @csbdresden.bsky.social. Agnes and her group work on protein plasticity and evolution. For her work, Agnes recently received the Schering Young Investigator Award 2025! youtu.be/lEpvGu3J63M?...
- Reposted by Toth-Petroczy labThe new @mpi-cbg.de research group leader Daniela Egas Santander is looking for a Postdoctoral Researcher (m/f/d) in Applied Topology for Biology. Apply until November 16th here: careers.mpi-cbg.de/jobs/6002777...
- Reposted by Toth-Petroczy lab💡With a #relational structure, programmatic access #API and improved search capabilities, CD-CODE 2.0 easily integrates into #datascience and digital #biology workflows, broadening its versatility and creating connections between condensate biology and #therapeutic development. 🔗 cd-code.org
- Reposted by Toth-Petroczy labCD-CODE is a great example of an interdisciplinary teamwork between computational and experimental biologists and software engineers! #Thankyou to all the authors of @tothpetroczylab.bsky.social, the biomolecular condensate community of @mpi-cbg.de, @hymanlab.bsky.social, and Dewpoint Therapeutics!
- Our enhanced knowledge base for condensates is online @narjournal.bsky.social! Congratulations to the first authors @kkuznetsova.bsky.social and @mscheremetjew.bsky.social and all co-authors & curators! What a wonderful team effort to advance condensate research! 🤩 @mpi-cbg.de @hymanlab.bsky.social
- CD-CODE 2.0 is now published in @narjournal.bsky.social 🤩 CD-CODE 2.0 stores #biomolecular #condensates and their #protein and nucleic acid components and now includes repository of 🦠 infectious condensates, 💊 condensate-modulating compounds, and 🩺 condensatopathies 👀 doi.org/10.1093/nar/...
- Reposted by Toth-Petroczy labSchering Young Investigator Award 2025 by the Schering Stiftung for Agnes Toth-Petroczy @tothpetroczylab.bsky.social @mpi-cbg.de @csbdresden.bsky.social. She receives the award for her work on the evolution, diversity, and function of proteins. Congratulations! 🎉 www.mpi-cbg.de/news-outreac...
- Reposted by Toth-Petroczy labAI can now generate fake microscopy images that are nearly impossible to detect. A serious threat to scientific integrity—and we’re not prepared for it. Commentary in @natnano.nature.com #nanotechnology
- Reposted by Toth-Petroczy lab🧬 We're excited to host the 13th Symposium on Structural #Proteomics at HT in Milan on 6–8 Oct 25! Join this international meeting with talks on protein structure and interactions by crosslinking MS, HDX-MS, native MS, chemoproteomics & more 👉 ssp2025.squarespace.com ▶️ @ssp2025.bsky.social
- Reposted by Toth-Petroczy labNovel Research in Biological Artificial Intelligence: Expressions of interest and nominations for a Max Planck Director to lead research in the field of Biological Artificial Intelligence @mpi-cbg.de and @csbdresden.bsky.social. More information: www.mpi-cbg.de/news-outreac...
- Reposted by Toth-Petroczy labScientific research is at the heart of Israel’s success and has worldwide benefits. Our work will continue despite adversity, says Alon Chen go.nature.com/40wXMx6
- Reposted by Toth-Petroczy labBig news 🎉 We are excited to announce the new TUD graduate school "Biomolecular Condensates: From Physics to Biological Functions", with 12 members from PoL! Through this school, we will train a new generation of scientists working on #condensates at the interphase between theory and experiments 🤓⤵️
- Hochaktuelles Themenfeld an der Schnittstelle von Physik, Biologie und Polymerforschung: Die @dfg.de fördert ab 2026 mit rund 7 Millionen Euro ein neues Graduiertenkolleg zur Erforschung biomolekularer Kondensate in #Dresden. 🔬 ℹ️ tu-dresden.de/tu-dresden/n...
- Reposted by Toth-Petroczy labThe latest release was supported by the #condesathon joined by @mpi-cbg.de condensate community🤩 Big #thankyou to all the participants from @hymanlab.bsky.social, @tothpetroczylab.bsky.social and von Appen labs for your support and enthusiasm!💜
- Reposted by Toth-Petroczy labRelated science sketch video by @marionamec.bsky.social www.youtube.com/watch?v=0REv...
- Are you looking for homologous sequences but alignments do not seem to work? SHARK is available as a webserver: compare sequences or search against precomputed IDR datasets: bio-shark.org @narjournal.bsky.social @mpi-cbg.de @csbdresden.bsky.social @poldresden.bsky.social doi.org/10.1093/nar/...
- Congratulations to the amazing team of Chi Fung Willis Chow, @mscheremetjew.bsky.social, Soumyadeep Ghosh, @annaha-poetry-art.bsky.social and HongKee and Lena from the Scientific Computing Facility @mpi-cbg.de! 🎉
- Reposted by Toth-Petroczy labOne week left to apply to the Physics of Life MSc this year! Students learn first-class research skills and can also avail of #scholarships to aid their studies. Learn more and apply: physics-of-life.tu-dresden.de/career-educa... #internationalstudents #MSc #EnglishMSc #Physics #studyabroad
- Good news: there will be 3 scholarships available for Physics of Life MSc students starting in 2025! ✅ €300/month for 1 year ✅ No separate application—admitted students are automatically considered. Apply now ➡️ tud.link/vejrmx #Biophysics #PhysicsofLife #StudyinGermany #Masters #Biology
- Reposted by Toth-Petroczy lab
Exciting that CD-CODE is now connected to THE go-to resource for everything protein-related! It's a great step forward, directing further developments and outlook for our project @tothpetroczylab.bsky.social @mscheremetjew.bsky.social 🥳 - Deep learning tools predict variants in disordered regions with lower sensitivity. Just published by FedericaLuppino, @swlenz.bsky.social and WillisChow @mpi-cbg.de @csbdresden.bsky.social @poldresden.bsky.social bmcgenomics.biomedcentral.com/articles/10....
- State-of-the-art VEPs tools have lower sensitivity but higher specificity for variants in disordered regions.
- It depends which disorder definition (score) is used. Only 7% of residues are consistently predicted as disordered across five different disorder prediction tools. flDPnn under predicts disorder compared to other methods.
-
View full threadWe conclude that new IDR-specific features and paradigms are needed to accurately classify disease mutations within those regions. Disorder-to-order transitions predicted by AlphaFold3 and motif predictions (e.g. by SHARK-capture) may aid structure-based variant interpretation.
- Reposted by Toth-Petroczy labNew Publication of the @tothpetroczylab.bsky.social: The group found that prediction tools are less sensitive in intrinsically disordered regions of proteins (IDRs). Since they are common & important, new methods tailored to these regions are needed. bmcgenomics.biomedcentral.com/articles/10....
- Reposted by Toth-Petroczy labThe @tothpetroczylab.bsky.social together with the @albertilab-tud.bsky.social developed SHARK-capture to detect recurring patterns (motifs) in intrinsically disordered protein regions (IDRs). Publication in Protein Science. www.mpi-cbg.de/news-outreac...
- Reposted by Toth-Petroczy labYou can download my protein structure-inspired artwork from pdb webpage: pdb101.rcsb.org/sci-art/bezs... @rcsbpdb.bsky.social @pdbeurope.bsky.social #sciart
- Identifying functional motifs in disordered regions is challenging. We gave it a try. Check out SHARK-capture, an alignment-free method to detect SLiMs. Congrats Chi Fung Willis Chow @swlenz.bsky.social et al. @mpi-cbg.de @csbdresden.bsky.social @poldresden.bsky.social doi.org/10.1002/pro....
- SHARK-capture is available as a Python package (pypi.org/project/bio-...) and on git (git.mpi-cbg.de/tothpetroczy...) where we provide bash scripts for parallelization on HPC and a colab notebook colab.research.google.com/drive/1l_hNY...
- SHARK-capture identifies a highly conserved motif (in pink) amongst Ded1p orthologs which regulates ATPase activity. Interestingly, AlphaFold2 predicts close proximity between the motif and the helices core.
- Proteome-wide predictions of motifs in S. cerevisiae are available. Matches to ELM motifs, UniProt motifs, and mutagenesis sites (UniProt) are enriched in SHARK-motifs compared to the random control. An example output: SHARK-capture score plot for Sic1.
- Reposted by Toth-Petroczy lab🍃CD-CODE update v1.09 is here!🍃 👀Check out the new #biomolecular #condensates at cd-code.org 👀We're continuing to update #Protein - #condensate connections and resolve issues! Join us to share your #condensate #expertise as a contributor: cd-code.org/signup #Bioinformatics #DatabaseUpdate #IDR
- Reposted by Toth-Petroczy labProgrammable viscoelastic hydrogels uncover mechano-sensing timescales and direct cell polarity biorxiv.org/content/10.1101/202…
- Reposted by Toth-Petroczy labMPI-CBG director Anthony Hyman @hymanlab.bsky.social will deliver the EMBO Lecture at the 49th FEBS Congress in Istanbul in July 2025. Read an interview with him, where he shares some of his inspirations and interests. network.febs.org/posts/anthon...
- Great opportunity if you are looking for an interdisciplinary postdoctoral position 👇
- Apply now for the ELBE Postdoctoral Fellows Program at the Center for Systems Biology @mpicbg.bsky.social @mpipks.bsky.social. The fully funded fellowships for postdoctoral researchers are designed for 2-3 years. Application deadline is February 14th. Join us! www.csbdresden.de/join-us/jobs...
- Reposted by Toth-Petroczy labMachine learning algorithm, PICNIC, can predict which proteins are involved in biomolecular condensates, regardless of their structure. Publication in @natureportfolio.bsky.social Communications by the @tothpetroczylab.bsky.social & @hymanlab.bsky.social www.mpi-cbg.de/news-outreac...
- Our PICNIC tool predicts condensate-proteins regardless of their structural disorder across organisms @naturecomms.bsky.social. Congratulations to @annaha-poetry-art.bsky.social for developing the algorithm and to Hari @hymanlab.bsky.social for the experiments! www.nature.com/articles/s41...
- Reposted by Toth-Petroczy lab✨Winter CD-CODE update to v1.08!✨ ❄️ New #biomolecular #condensates added (total ⚪: 680) ❄️ #Protein - #condensate connections updated ❄️ Species attributes fixed 🤩 👀Check the current version here: cd-code.org Join us to become a contributor: cd-code.org/signup #DatabaseUpdate #Bioinformatics #IDR
