Tanja Mittag
Phase separation and disordered proteins!
All comments/opinions are my own and are not representative of St. Jude.
- Faculty retreat of @stjuderesearch.bsky.social today. We see evidence everywhere of how Jim Downing shaped the vision for St. Jude over the last twenty years. The results are cutting edge fundamental science, St. Jude Global and important new initiatives. Inspiring!
- Reposted by Tanja MittagNew preprint with work led by @asrauh.bsky.social in which we explore how double mutant cycles could be used to study molecular interactions in condensates, and highlight difficulties in extracting information about interactions from mutational experiments www.biorxiv.org/content/10.6...
- On the Use of Double Mutant Cycles to Probe the Molecular Interactions in Biomolecular Condensates biorxiv.org/content/10.64898/20…
- Reposted by Tanja MittagDoes targeting enzymes and substrates in a condensate lead to rate enhancement? No. Here, we investigate how the condensate environment can inhibit an enzyme reaction. Spoiler: Mass-transport limitations. We find a strong correlation between diffusion and reaction rates. doi.org/10.64898/202...
- Reposted by Tanja MittagI am recruiting postdoctoral fellows to develop new research directions in the lab. We study transcriptional regulation through biomolecular condensates in development and disease, with an emphasis on first-principles and mechanistic discovery. Please repost or share with colleagues.
- Reposted by Tanja MittagSecond preprint of the year in which @sarahgersing.bsky.social from @rhp-lab.bsky.social mapped the effects of >7500 variants in glucokinase (GCK) on the interaction with the glucokinase regulatory protein so that we now have a 3D GCK scan (abundance, interaction, activity) doi.org/10.64898/202...
- New preprint! Led by @sarahgersing.bsky.social we map how 7,500+ variants in glucokinase (GCK) affect binding to GKRP and disentangle this from stability. We now have activity, abundance, and interaction scores for 7,128 GCK variants - a resource for understanding phenotypes and glucose homeostasis.
- Reposted by Tanja MittagAre you a junior scientist working in theoretical biophysics? @zamakany.bsky.social and I are organizing another workshop this fall here at @hhmijanelia.bsky.social. Travel and the workshop expenses are all covered! tinyurl.com/yc66fawc
- Reposted by Tanja MittagIDPSeminars is BACK THIS WEEK! Talks from Andrea Soranno and @bokaizhulab.bsky.social on Thursday! 1 pm EST / 7 PM European time! Sign up here: forms.gle/3yCHeYvuuqLh... And check out the full Spring 2026 schedule at idpseminars.com!
- Reposted by Tanja MittagNuclear speckle associated RRM-containing proteins are block copolymers. They make size-limited, ordered microphases, tens of nm in size comprising tens of molecules. Speckles are likely clusters or emulsions of distinct microphases and not macrophases www.sciencedirect.com/science/arti...
- Reposted by Tanja Mittag🚨New preprint(1/2)! We show that RTK fusion oncoproteins broadly suppress EGFR signaling. How? Sequestration of adapters as the shared principle. Led by superb PhD student Carol Gao. www.biorxiv.org/content/10.1... Implications for drug tolerance/resistance, and includes one big surprise🫧.👇
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- Reposted by Tanja MittagOur review on Integrative modelling of biomolecular dynamics 💃 is now live at COSB We discuss approaches to integrate computational methods with time-dependent & time-resolved experiments to study protein dynamics With @dariagusew.bsky.social & Carl G. Henning Hansen doi.org/10.1016/j.sb...
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- Reposted by Tanja MittagNew preprint! We measured temperature- and pH-induced aggregation for over 18,000 natural and de novo designed protein domains!
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- Reposted by Tanja MittagRe-boosting! The Dept. of Microbiology 🧫 at the University of Tennessee is hiring two 9-month faculty! Come join a vibrant and growing department located in the foothills of the Smoky Mountains! #microsky
- Come join us in Knoxville! The Dept. of Microbiology 🧫🦠 at the University of Tennessee is hiring 2 Assistant Professors (tenure track, 9-month appt.). Microbial Drivers of Chronic Disease: apply.interfolio.com/173153Quantitative Microbe-Plant-Environment Interactions: apply.interfolio.com/173345
- Reposted by Tanja Mittag📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Integrative Structure Biology with a focus on in situ structural biology using cryo-electron tomography (cryo-ET) and related methods. More details ➡️ tinyurl.com/brswbymu
- Reposted by Tanja MittagWe (@sobuelow.bsky.social) developed AF-CALVADOS to integrate AlphaFold and CALVADOS to simulate flexible multidomain proteins at scale See preprint for: — Ensembles of >12000 full-length human proteins — Analysis of IDRs in >1500 TFs 📜 doi.org/10.1101/2025... 💾 github.com/KULL-Centre/...
- AF-CALVADOS: AlphaFold-guided simulations of multi-domain proteins at the proteome level biorxiv.org/content/10.1101/202…
- Reposted by Tanja MittagDuring these uncertain times, I’m very happy to see that my institution, @scripps.edu has an open tenure-track Assistant Professor position. Any field in Chemistry or Biology is welcome. I’d especially love to see fellow neuroscientists apply. Please repost! apply.interfolio.com/174756
- Reposted by Tanja MittagJOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada at @sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto. www.nature.com/naturecareer... Please repost!
- Reposted by Tanja Mittag🚨The 2026 IDP GRC Program is LIVE! 📣 Check it out: www.grc.org/intrinsicall... We’ve got an incredible speaker lineup! 🌟 Over the next few weeks, we’ll be highlighting some of them and giving you a sneak peek at the exciting topics they’ll be covering. Stay tuned!
- Reposted by Tanja MittagOpen faculty position! We're seeking applicants for a tenure-track faculty position at the junior level (Assistant or untenured Associate Professor) with research programs that exist at the interface between molecular science and computation. Apply here: stanford.io/45MF3Qa
- Reposted by Tanja Mittag🚨🚨The GRC on Intrinsically Disordered Proteins #IDPs is back!! 🍝🧵🏔️Join us for cutting-edge IDP science, great discussions, and mountain views 🌄🍝 📅 June 21-26, 2026 | Les Diablerets, Switzerland 👉 Details & registration: grc.org/intrinsicall...
- Reposted by Tanja MittagWhy are transcription factors disordered? Come join us in Oxford as a postdoc and we'll find out together! Help publish 3 mature projects, AND develop cool new single molecule fluorescence binding assays! biophysics transcription protein:DNA interactions my.corehr.com/pls/uoxrecru...
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- Reposted by Tanja MittagWe are hiring an Assistant Professor of Biochemistry and Biophysics at Weill Cornell Medicine. Come join our collaborative research environment with state-of-the-art facilities in NYC! Application review starts Oct 22. biochem.weill.cornell.edu/join-our-fac...
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- Reposted by Tanja MittagDid you know about the BPS Bridging Funds Program? If you're a biophysicist navigating a difficult time, this program is for you to defray costs for attending the BPS Annual Meeting! I am grateful to the @biophysicalsoc.bsky.social for supporting our members! www.biophysics.org/2026meeting/...
- Reposted by Tanja MittagWow Karolinska Institutet is recruiting 20 outstanding early-career researchers for assistant professor positions ki.se/en/about-ki/...
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- New paper on transcription factor phase separation published from my colleague Aseem Ansari's and my lab: Reconciling competing models on the roles of condensates and soluble complexes in transcription factor function authors.elsevier.com/sd/article/S...
- Reposted by Tanja MittagKarolinska is looking for 20 (!!) assistant professors and offering 6 year appointments with ~1M USD startup packages. ki.se/en/about-ki/...
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- New paper out from the Mittag lab: www.biorxiv.org/content/10.1... New adventures in understanding structure and function of SPOP, which involve donuts! 🍩 Congratulations to first authors Matt Cuneo, Ömer Güllülü and Mohamed-Raafet Ammar, and all other authors!
- Reposted by Tanja MittagI spoke with Jade Hindmon, host of @kpbssandiego.bsky.social Midday Edition, about the consequences of the current administration’s cuts to science funding. Please share to help spread the word and raise awareness. www.kpbs.org/podcasts/kpb...
- Reposted by Tanja MittagWelcome to the Biological Physics of Biomolecular Condensates: Bridging Theory and Experiment (#biomol-c25) Conference at #KITP Learn more at: buff.ly/HHQAdGh If you are unable to attend in person or want to revisit any talks, recorded sessions are available to watch at: buff.ly/ufXjSxG 🧪
- Reposted by Tanja MittagLively poster session after a day full of talks (😅) by @drummondlab.bsky.social, Allie Obermeyer, @albertilab-tud.bsky.social, Sam Safran, and @tanjamittag.bsky.social at the #KITP biomol25 conference on biomolecular condensates. Great conversations between theorists and experimentalists!
- Reposted by Tanja Mittag"TENURE-TRACK FACULTY POSITIONS INSTITUTE OF PLANT AND MICROBIAL BIOLOGY at Academia Sinica, Taipei, Taiwan *Application Deadline: 8/31/2025" Read more here: arabidopsis.org/news/jobs/view?file… #PlantSciJobs
- Thank you, @philipcball.bsky.social ! It was a pleasure to meet you in person!
- Reposted by Tanja MittagAre you looking for a faculty job? We are hiring in my department at Roswell Park NOW. Contact me for details as I await the formal ad. (Please RT.)
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- Reposted by Tanja MittagBiomolecular condensates are shape shifting bits of DNA, RNA and proteins that “condense” molecules to key locations inside our cells. I call em "power blobs" cuz I'm fun like that. 🧪 🩺 Research from @rohitpappu68.bsky.social with @stjuderesearch.bsky.social source.washu.edu/2025/05/rese...
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- Are stress granules crucibles or protective against amyloid fibril formation? Read about our work at Mol Cell: "Tunable metastability of condensates reconciles their dual roles in amyloid fibril formation". Wonderful collaboration with @rohitpappu68.bsky.social and other colleagues (see next post)!
- With @tanjamittag.bsky.social we asked if A1-LCD condensates are protective or crucibles for amyloid fibril formation. Their interfaces enable fibril nucleation but their interiors suppress fibril formation. Insights were transferrable to stress granules in cells. doi.org/10.1016/j.mo...
- Postdocs @tapojyotidas.bsky.social and Fatima Zaidi from my lab tackled this question with Mina Farag and Kiersten Ruff in Rohit's lab. @priya-r-banerjee.bsky.social and Tharun Mahendran and Anruag Singh came up with a neat condensate efflux assay. Collaboration with Paul Taylor on cellular data.
- Reposted by Tanja MittagGemma Solomon and I are looking for a postdoc to work across the two groups on modelling biological systems with a view to applications for quantum computing More details about the project including how to apply in the link below. Deadline April 9 2025 candidate.hr-manager.net/ApplicationI...
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