Centre for Synthetic Biology @TUDarmstadt: The group of Harald Kolmar has expanded the Antibody-Drug-Conjugates (ADCs) toolbox🧪: Pyrococcus horikoshii biotin ligase (PhBL) enables site-specific conjugation to trastuzumab via a p67-tag. Check out the article at ChemBioChem: chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10....

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Centre for Synthetic Biology @TUDarmstadt synbio.bsky.social
The group of Harald Kolmar has expanded the Antibody-Drug-Conjugates (ADCs) toolbox🧪: Pyrococcus horikoshii biotin ligase (PhBL) enables site-specific conjugation to trastuzumab via a p67-tag. Check out the article at ChemBioChem: chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10....
A Recognition Tag of Human Origin for Bioorthogonal Generation of Antibody‐Drug Conjugates using Microbial Biotin Ligase

The use of enzymes such as microbial transglutaminase, lipoate protein ligase A or sortase A for the generation of antibody-drug conjugates (ADCs) has proven to be a powerful tool for the site-specif...

chemistry-europe.onlinelibrary.wiley.com
Apr 22, 2025 13:59
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