- We’re thrilled to share our Nature Methods review on #CellPainting — your go-to resource for mastering Cell Painting! From MOA and toxicity prediction to contributing to candidate drugs in clinical trials, we’ve distilled 10 years of insights!
- What is Cell Painting? It's a microscopy-based, high-content assay that uses six fluorescent dyes to "paint" cells, capturing thousands of features like size, shape, texture, and intensity. The goal? Reveal cellular responses to perturbations in a target-agnostic way.
- Why it matters: Cell Painting unlocks phenotypic profiling, helping researchers understand drug mechanisms of action (MoA), predict toxicity, and even design safer, more effective compounds. It's cost-effective, scalable, and widely accessible.Dec 5, 2024 17:35
- Applications that are changing the game: Predicting MoAs: By comparing unknown compounds to landmark ones. Toxicity profiling: From mitochondrial health to drug-induced liver injury. Disease modeling: Creating phenotypic signatures for rare diseases, ...among others
- What excites you most about the future of Cell Painting? Share your thoughts below!
