Great work from Gloria Brar’s group on the role of paralogous RNA helicases in the heat shock response. Surprising increase in growth at high temperature and impact of a short motif! Also important implications of the role of biomolecular condensation. Awesome
www.cell.com/cell-reports...
Analyses of translation factors Dbp1 and Ded1 reveal the cellular response to heat stress to be separable from stress granule formation
Kuwayama and Powers et al. reveal differences in function for two related RNA remodelers. Dbp1 is poor at stimulating translation, but, when expressed instead of Ded1, it prevents cells from halting growth upon heat stress. This depends on a short disordered Ded1 region but not stress granule formation or reduced translation.
