Can HIV become resistant to lenacapavir?
An analysis of clinical isolates identifies mutations that shift the capsid protein’s lenacapavir binding pocket and endow resistance, but shows these mutations often come at a high fitness cost.
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Lenacapavir treatment–emergent HIV-1 capsid resistance mutations are frequently associated with replication defects
Treatment-emergent capsid mutations elicited by lenacapavir monotherapy showed variable drug resistance and viral fitness impacts.
