Sandy Anderson
Mathematical oncologist working on cancer evolutionary therapy #AndersonLab @mathonco.bsky.social Chair @EvolTherapy.bsky.social Director @smbmathbiology.bsky.social Fellow and former President
- Reposted by Sandy AndersonHad a fantastic time presenting my research at MathOnco25. Looking forward to IMO workshop! @mathonco.bsky.social
- Reposted by Sandy AndersonLast speaker at #MathOnco25 is our own @mathonco.bsky.social Jeffrey West that provides a study of the #mathonco literature to produce this definition of MathOnco: the use of interpretable models to understand and improve cancer therapy
- Reposted by Sandy AndersonGreat last didactic at #MathOnco25 by @andriy-marusyk.bsky.social describing the complex landscape of evolutionary and ecological mechanisms aiding cancers become treatment-resistant. Andriy and I both share the idea of maps as an example of what models can be
- Reposted by Sandy Anderson4th (and last) day of #MathOnco25. Excellent work @sandyanderson.bsky.social and @gliomath.bsky.social. Looking forward the next one, hopefully in 2026
- Reposted by Sandy AndersonLast keynote at #MathOnco25 by Sarah Bruningk talking about #AI in #Medicine. While generally optimistic about AI in medicine she is aware of the challenge that AI works best when there is a lot of data and that is almost never the case in clinical oncology
- Reposted by Sandy AndersonIn her #MathOnco25 plenary, Sarah Brüningk motivates mechanistic learning in mathematical oncology, drawing on her recent review paper: www.frontiersin.org/journals/imm...
- Reposted by Sandy AndersonBob Gatenby finishes his phenomenal #MathOnco25 talk with this stunning figure and conclusion: "Cycles within cycles may allow metastatic prostate cancer to be converted to a chronic disease". The results are from a new paper: onlinelibrary.wiley.com/doi/10.1002/...
- Reposted by Sandy AndersonJoel Brown at #MathOnco25 draws parallels between the evolution and ecology of cancer and of dogs, elephant shrews and (of course) squirrels. Cancer redefined as "a disease of uncontrolled proliferation by transformed cells subject to evolution by natural selection". aacrjournals.org/mcr/article/...
- Reposted by Sandy AndersonNow @kitcgallagher.bsky.social at #MathOnco25 presents his recent research on predicting treatment outcomes to identify which patients will benefit the most from adaptive therapy. Preprints and papers at scholar.google.com/citations?us...
- Reposted by Sandy AndersonFranco Pradelli presents one of the most beautiful slides so far at #MathOnco25, on the topic of exploiting the cost of addiction in anaplastic large cell lymphoma
- Reposted by Sandy AndersonFantastic to have adaptive therapy pioneer Jingsong Zhang here at #MathOnco25 talking about a third-generation adaptive therapy trial for metastatic prostate cancer underway at the Moffitt Cancer Center, informed by Jill Gallagher's mathematical modelling. Preprint: www.medrxiv.org/content/10.1...
- Reposted by Sandy AndersonThursday keynote at #MathOnco25 with @robjohnnoble.bsky.social showing a wealth of #MathOnco models of cancer evolution and evolutionary-enlightened therapies. Notice the bingo card: he showed enough different math models to fill up the card!
- Reposted by Sandy AndersonReally nice #MathOnco25 talk by Einar Bjarki Gunnarsson on optimal dosing of anti-cancer treatment under drug-induced plasticity, showing "that the optimal dosing strategy steers the tumor to a fixed equilibrium composition between sensitive and tolerant cells" www.nature.com/articles/s41...
- Reposted by Sandy AndersonNow at #MathOnco25, co-organiser @gliomath.bsky.social presents recent work showing that the predictions of an AI method massively improved when coupled with a mechnaistic mathematical model www.nature.com/articles/s41...
- Reposted by Sandy AndersonFrom Tampa to the gorgeous St. Pete for #MathOnco25. Science and views for the next few days! 😍
- Reposted by Sandy AndersonGreat talk by collaborator Joon Hyun Song from @ceel-damaghilab.bsky.social working on a simple model of the storage effect to explain the role of temporal fluctuations in intra tumor heterogeneity #MathOnco25
- Reposted by Sandy AndersonAt #MathOnco25, @rrockne.bsky.social explains why he so loves SINDy (sparse identification of nonlinear dynamics).
- Reposted by Sandy AndersonGreat didactic at #MathOnco25 by @rrockne.bsky.social who starts his presentation with a very Freudian slip by thanking organizers @gliomath.bsky.social and #SINDy (meaning @sandyanderson.bsky.social)
- Reposted by Sandy AndersonFirst plenary talk at #MathOnco25 today is Harvard's Galit Lahav about the temporal dynamics of p53 and how it lends itself to #MathModeling
- Reposted by Sandy AndersonDay 2 of #MathOnco25 in St Pete Beach, FL
- Reposted by Sandy AndersonGreat didactic at #MathOnco25 by @dwodarz.bsky.social showing the importance of space...and turnover in #cancerevolution
- Reposted by Sandy AndersonOur own Tatiana Miti highlighting the importance of data to find out the initial configuration of an ABM describing early stages in metastasis, something which is hard to study with experimental models and clinical data #MathOnco25
- Reposted by Sandy AndersonA man after my own heart! @dwodarz.bsky.social on the importance of spatial structure in tumour evolution #MathOnco25
- Reposted by Sandy AndersonAt #MathOnco25, @cancerevo.org talks about how to model the role of the tumor microenvironment in cancer initiation, progression, and treatment resistance. He finishes by advertising the Moffitt IMO PhD program www.moffitt.org/education/re...
- Reposted by Sandy AndersonNow at #MathOnco25, @ceel-damaghilab.bsky.social advocates "3D spheroids as a simplest model of tumor ecosystem". His beautiful data make a strong case.
- Reposted by Sandy AndersonFirst didactic of the day at #MathOnco25 is Stony Brook's @ceel-damaghilab.bsky.social about the breast ecosystem. The early breast cancer ecosystem is a tumor incubator
- Reposted by Sandy AndersonSetting the tone for #MathOnco25, @stroblmar.bsky.social (now based in London) outlines the benefits of theory-experiment integration
- Reposted by Sandy AndersonCo-organiser @sandyanderson.bsky.social is about to kick off the four-day #MathOnco25 meeting. And you can join us online! moffitt.zoom.us/j/95801446916
- Reposted by Sandy AndersonWell, #IMO retreat is underway now and here is our very own @sandyanderson.bsky.social describing some of the changes and accomplishments at @mathonco.bsky.social since our last retreat in 2018
- Next ups is panel 3 at #NFCR with Elena @fertiglab.bsky.social from @genomescience.bsky.social discussing the role of ‘AI in early detection and prevention’
- Paul @mathcancer.bsky.social was rocking the stage at #NFCR as part of the second panel discussion on ‘AI in cancer diagnosis and management’. It’s cool to see the important role of #MathOnco folks in these types of discussions.
- Reposted by Sandy AndersonReally thrilled to be at the National Press Club today for the NFCR Summit on Cancer Care. My great friend @sandyanderson.bsky.social is on the first panel on AI and cancer care. I'll be on the next panel. :-) 🧪
- Reposted by Sandy AndersonAlways a thrill to see my dear friend @sandyanderson.bsky.social present his groundbreaking work in model-guided adaptive cancer therapy at this year's @jktgfoundation.bsky.social breast cancer symposium. 🧪
- Last weeks @mathonco.bsky.social research in progress is by Agata Xella from the #AndersonLab presenting, Modeling CDC7i and PKMYT1i Synergy in Ovarian Cancer @moffittnews.bsky.social
- Fab closing presentation by friend and #mathonco agitator @gliomath.bsky.social from @cedarssinaicancer.bsky.social presenting cool new work, Every Patient Deserves Their Own Equation: Towards Digital Twins for Neuro-Oncology.
- The penultimate talk is from friend and collaborator Mark Chaplain from St. Andrews University presenting, A Mathematical Modelling Framework for a Virtual Solid Tumour: Foundation for an Oncological Digital Twin.
- Next up is Katie Bentley from @crick.ac.uk on Simulating pathological vascular dynamics.
- Opening the afternoon session is Hector Gomez from Purdue University presents, Prostate: Small Organ, Big Problems—informing clinical decisions with computational models.
- Excited to announce that registration for the 13th @mathonco.bsky.social workshop on Treatment Revolution is now open. Held onsite @moffittnews.bsky.social Nov 2-Nov 7 #MoffittIMO more details: imo13.eventbrite.com. Deluxe travel awards are available on a competitive basis, apply by 10/03!
- If you are interested in learning more about what an IMO Workshop is like check out our dedicated website: imoworkshop.org. Note the workshop this year runs directly after our #MathOnco25 meeting: mathematical-oncology.org/mathonco25.
- Closing the morning session is Olivier Gevaert from @stanforduniversity.bsky.social presenting, Multimodal data fusion for precision medicine and digital twins.
- Next is friend and fellow Department chair @gibin.bsky.social from @swanseauni.bsky.social presenting, A Multiscale Modelling Framework for Studying Cancer Growth and Treatment Responses.
- Next is Simon Walker-Samuel @ucl.ac.uk presenting, Digital twins of the retina as a model for cancer.
- Reposted by Sandy AndersonInterested in doing a PhD in #MatOnco next year? Our department at @moffittnews.bsky.social is a great place to do research and we offer fully-paid tuition and fees. Apply before the deadline 12/1 at Moffitt.org/CancerPhD
- Then our very own Jill Gallaher discusses our ongoing @evoltherapy.bsky.social clinical trial with @genentech.bsky.social on, Adaptive therapy in advanced basal cell carcinoma driven by imaging and predictive mathematical. #AndersonLab @mathonco.bsky.social @moffittnews.bsky.social
- Next up was short presentations by Luciana Luque from @cruk-si.bsky.social discussing, From measurement to decision: a tissue-aware digital-twin platform for CAR T cell dosimetry.
- Opening day 2 of Mathematical Foundations of Oncological Digital Twins at The NewtonI nstitute is Trachette Jackson from @umich.edu presenting, From PD-L1 to PSA: Virtual Clones and Cohorts in Action Across Cancer Types and Therapeutic Modalities.
- Final presentation for today by Richard Gilbertson from Cambridge University and CRUK Cambridge Institute presenting, Context Drift and the Virtual Mouse: new approaches to better cancer treatments.
- Next Justicia Kyeremeh from Cambridge University presenting, From Data to Decisions: Building the Digital Twin Framework for Personalised Kidney Cancer Surgery.
- Opening the final session for today is Anna Sher from GSK presenting, Oncological Digital Twins in Drug Discovery and Development: A Quantitative Systems Pharmacology Perspective. Sadly most of the slides couldn’t be shared. But Anna’s message was industry is ready to share!
- Opening the afternoon session is Jasmine Fisher from @ucl.ac.uk presenting, Precision Oncology through Digital Twins: Mechanisms, Models, and Clinical Applications.
- Next up is friend and community player extraordinaire @mathcancer.bsky.social from Indiana University presenting, Advances in building patient-specific agent-based models in cancer.
- Next up is friend and collaborator @trevorgraham.bsky.social from @icr.ac.uk presenting, Modelling drug resistance evolution. Most of his talk is unpublished so I didn’t photograph it!
- Next up is @eriksahailab.bsky.social from the @crick.ac.uk presenting, Using inference and modelling to understand how cancers change over time.
- It was great to see friend and former @mathonco.bsky.social member @stroblmar.bsky.social presenting a vision for his independent research here in the UK! He’s gonna be one to watch for sure.
- Attending ‘Mathematical Foundations of Oncological Digital Twins’ meeting at the Newton Institute in Cambridge organised by Steven Niederer and Helen Byrne. Watch along with me here: www.newton.ac.uk/event/ooew07/
- Reposted by Sandy AndersonGood friend @sandyanderson.bsky.social is giving the 1st keynote address on virtual cancer trials, virtual tumor boards, and using patient-calibrated models to plan individual treatments to delay therapeutic resistance. Groundbreaking work making a difference in real patient trails! #mathonco
- Reposted by Sandy AndersonStudying cancer evolution needs multi-region or single cell seq for phylogenetics, right? Amazingly (I think!) we found single-sample bulk methylation suffices, via analysis of "fluctuating methylation". In @nature.com today led by brilliant @calumgabbutt.bsky.social www.nature.com/articles/s41...
- Today’s @mathonco.bsky.social research in progress is from Jeffrey West lab member Ari Barnett presenting, Moment-Informed Radiotherapy: Inferring inter-patient radiosensitivity with probability convolution @moffittnews.bsky.social
- For last weeks @mathonco.bsky.social research in progress we had the new chair of Translational Pathology, Ignacio Wistuba sharing his vision for the new department that will explicitly integrate computational approaches @moffittnews.bsky.social
- I’ve not been on top of my research in progress presentations for @mathonco.bsky.social So here are some catch ups! 2 weeks ago we have Tao Li from @einsteincross.bsky.social lab on, Characterizing how selection pressures shape Karyotype Fitness Landscapes (KFLs) @moffittnews.bsky.social
- #MathOnco25 Abstract submission is being extended until this Friday the 5th of September! So please go ahead and submit asap to have a chance of getting one of our travel awards! mathematical-oncology.org/mathonco25
- Reposted by Sandy AndersonThis paper took the scenic route to publication: paused for maternity leave, rerouted by other work priorities, and finally dusted off like a forgotten treasure in the attic when my brilliant student Amy came on board.
- Save the date #MathOnco25! October 29th-31st in Tampa, Florida. Directly before the 13th IMO Workshop (November 3rd-7th) - stay the weekend and brainstorm the beaches! More information to follow but @evoltherapy.bsky.social will be a key theme @mathonco.bsky.social @moffittnews.bsky.social
- Abstract submission is now open for #MathOnco25! So please go ahead and submit asap to have a chance of getting one of our travel awards: mathematical-oncology.org/mathonco25
- Reposted by Sandy AndersonReally excited to share our new @cellpress.bsky.social Cell paper with @fertiglab.bsky.social and colleagues. 1/n www.cell.com/cell/fulltex... @jktgfoundation.bsky.social @itcrtraining.bsky.social @smbmathbiology.bsky.social #mathbio #mathonco @mathonco.bsky.social @deniswirtz.bsky.social
- Reposted by Sandy AndersonOut now @dev-journal.bsky.social Transition paths across the epithelial-mesenchymal transition landscape are dictated by network logic Through investigation into the role of logic in GRN models, we discovered that choice of logic (AND vs OR) profoundly impacts cell fate. doi.org/10.1242/dev....
- Closing this session is another one of our @mathonco.bsky.social faculty, @cancerevo.org David Basanta: "Calibrating a Spatial Agent-Based Model of Multiple Myeloma Using In Vivo Data to Predict Immunotherapy Response" #SMB2025 @moffittnews.bsky.social
- Next up is our very own @mathonco.bsky.social faculty @rejniaklab.bsky.social presenting, "Using tumor histology to analyze cancer immunotherapies with the agent-based micropharamacology model" #SMB2025 @moffittnews.bsky.social
- Now attending a minisymposium on parameterising agent based models organized @dwodarz.bsky.social lab, 1st up is @utaustin.bsky.social member David Hormuth on "Leveraging longitudinal experimental data to parameterize mathematical models of tumor growth and response” #SMB2025
- Former HAL developer and @mathonco.bsky.social student, Rafael Bravo now with @utaustin.bsky.social presents new work on: "Testing the feasibility of estimating the migration to proliferation rate ratio in glioblastoma from single time-point MRI data" #SMB2025
- Today’s morning plenary and John Jungck Prize lecture is from @smbmathbiology.bsky.social former president, Fred Adler (@dendroicap.bsky.social) on "Education, Bureaucracy and Corruption". He manages to discuss some of his virus work with former @mathonco.bsky.social member Anna Miller! #SMB2025
- Reposted by Sandy AndersonYesterday's #mathonco minisymp with @mathonco.bsky.social @moffittnews.bsky.social's chair and friend @sandyanderson.bsky.social presenting models that capture patient data and help us to understand how to improve treatment schedules in a clinically translatable way
- Reposted by Sandy Anderson"Patients should be their own control" - great & pithy takeaway from @sandyanderson.bsky.social in his talk on the adoption of adaptive therapies in the clinic #SMB2025 #MathOnco
- Next up is friend and collaborator @rrockne.bsky.social from @cityofhope.bsky.social presenting "State-transitions at the single cell and system levels in chronic and acute myeloid leukemia" #MathOnco #SMB2025
- Next up is Sara Hamis @uppsalauniversity.bsky.social in a parallel #MathOnco session on "Growth rate-driven modelling elucidates phenotypic adaptation in BRAFV600E-mutant melanoma" #MathOnco #SMB2025
- Next up is former student & friend @stroblmar.bsky.social presenting new work with @cancerconnector.bsky.social on “Bridging the gap: What preclinical experiments can teach us about cancer drug scheduling” #MathOnco #SMB2025
- Opening 1 of 3 parallel #mathonco sessions this AM is Thomas Yankeelov from @utaustin.bsky.social shows "A practical computational framework for systematically investigating alternative treatment strategies for cancer”. Tom show realworld results from a digital twins driven clinical trial! #SMB2025
- A packed opening plenary from one of the @smbmathbiology.bsky.social Canadian giants! Mark Lewis “One equation helps solve three paradoxes in the spatial ecology of predators and prey” Mark also wins the prestigious Akira Okubo Prize!! #SMB2025
- Reposted by Sandy AndersonOver a month ago a bunch of #MathOnco and #AIOnco researchers got together in Syracuse to discuss how #AI may and may not change the field. Here are some thoughts in a collective effort led by @rrockne.bsky.social:
- Reposted by Sandy AndersonA week away from the start of the @smbmathbiology.bsky.social meeting in #Edmonton so it seems like an apt time to share my convo with conference organizer, Jay Newby. You'll also hear me nerding out about potassium channels in neurons 🧠 smb.org/news/13516785 #SciencePodcast #BiologyInNumbers
- Reposted by Sandy AndersonA behind-the-paper post by Einar Gunnarsson: Optimal #dosing of anti-cancer drug treatment under drug-induced #plasticity
- Reposted by Sandy AndersonBig shout out to rising M4 and CWRU MSTP student Eshan King - whose paper came out in @aaas.org Science Advances. connecting the fields of PK-PD and evolutionary modeling using fitness seascapes. #mathevo #mathonco @cbo.bsky.social @sandyanderson.bsky.social www.science.org/doi/10.1126/...
- Reposted by Sandy AndersonFantastic upcoming 2-day workshop on digital twins for cancer care at Oxford's Isaac Newton Institute, September 18-19 this year. This workshop will have a fantastic set of experts, and I'll also give a keynote talk on our cancer immunology work. 🧪 1/8 Apply at: www.newton.ac.uk/event/ooew07/
- Reposted by Sandy AndersonWOW!.. 8500+ supporting cast heroes (that's us!) have already signed our Letter of Support for the brave NIH heroes who laid down their case in the historic #BethesdaDeclaration. Add your name here actionnetwork.org/forms/add-na... & stand up to save science & health in America. #StandUpForScience
- Attending a conference entitled, The Future of Cancer Research: Unleashing the Power of Machine Learning, taking place in the historic city of Syracuse. Organized by @cityofhope.bsky.social @sergiobranciamore.bsky.social, Andrei Rodin, Konstancja Urbaniak and @rrockne.bsky.social
- First up is Aleksandra Karolak from @moffittnews.bsky.social Machine learning presenting, Molecular Dynamics and Artificial Intelligence – Capturing Molecular Interactions.
- This is a very discussion driven meeting with only two major presentations each day. The second was a @cityofhope double act Konstancja Urbaniak and Babgen Manookian discussing Static and Dynamic Bayesian Networks in Biomarker and Drug Discoveries
- A massive @mathonco.bsky.social congratulations to Dr. Weh @gosiaweh.bsky.social on successfully defending her PhD. Also a shoutout to both her advisors @cancerevo.org and Andriy Marusyk @moffittnews.bsky.social
- Today David @cancerevo.org lab member @gosiaweh.bsky.social defends her @mathonco.bsky.social PhD on, The Only Constant is Change: the Role of Genetic Diversification in Cancer and Beyond. Here David introduces external examiner @cancerconnector.bsky.social. Gosia starts with moth evolution!
- Gosia uses our Hybrid Automata Library (HAL) to investigate the fitness effects of new mutations in an explicitly spatial model where competition is purely driven by space @mathonco.bsky.social @moffittnews.bsky.social
- @gosiaweh.bsky.social thanks the @mathonco.bsky.social family and beyond for an exciting 5 year journey! She also especially thanks her cat Nikolai!
