Ryan Hisner: While transmission is unlikely it can't be ruled out. At least 2 Cryptic-like variants have transmitted: • Early 2022, Iran, 4 patients, ≥1 death (a child) • From Canary Islands (Dec 2022/Jan 2023) to Spain (Oct 2024), 2 patients, ≥1 death. bsky.app/profile/ryan...

Ryan Hisner ryanhisner.bsky.social · Jan 24
New Cryptic (North Carolina) derived from a 2020, pre-B.1.1 lineage, meaning from an infection that has lasted nearly six years. It has one of the classic patterns of Cryptic reversions to Bat-CoV/SARS-1 spike residues: Q498Y-N501T. Eager to see the rest of the genome.
- Solid Evidence handle.invalid · Jan 24
  We found a new (I think) cryptic lineage this week. I know I say this all the time, but this is really weird. Warning, this thread is for nerds only. 1/
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Ryan Hisner ryanhisner.bsky.social
While transmission is unlikely it can't be ruled out. At least 2 Cryptic-like variants have transmitted: • Early 2022, Iran, 4 patients, ≥1 death (a child) • From Canary Islands (Dec 2022/Jan 2023) to Spain (Oct 2024), 2 patients, ≥1 death. bsky.app/profile/ryan...
- Ryan Hisner ryanhisner.bsky.social · Nov 22, 2025
  Fascinating 🧵. The grotesquely mutated spike of this NJ Cryptic binds ACE2 very tightly. It raises a broader question: Can cryptic wastewater-like lineages transmit? YES We knew it happened once. Now we know it's happened at least twice. The results in both cases were not pretty. 1/15
Jan 25, 2026 03:24
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