Ronan Doyle
Lead Clinical Bioinformatician in Pathogen Sequencing at St Thomas' Hospital in London, UK (Synnovis).
Working on infectious disease diagnostics, pathogen genomics and metagenomics.
- Reposted by Ronan DoyleOur latest preprint compares the dual-arm nanopore workflow with the respiratory metagenomics protocol currently implemented across the NHS, using clinical samples. 👉 www.researchsquare.com/article/rs-8... @nhsmetagenomicsnet.bsky.social @lukebsnell.bsky.social @ronandoyle.bsky.social
- As part of the @nhsmetagenomicsnet.bsky.social we have compared the current in-service nanopore metagenomics protocol with ONT's own dual-arm protocol. The results are published in the following preprint: www.researchsquare.com/article/rs-8...
- Reposted by Ronan DoyleHappy to share our new AMR resource which has phenotypic AMR (usually MIC data) collected from publications and databases. This is paired with assemblies and annotations We're excited for users who might train new models, find phenotype/genotype mismatches, or any other use
- Antimicrobial resistance (AMR) is a growing health threat, making infections harder to treat and complicating routine medical care. EMBL-EBI’s new AMR portal brings together laboratory resistance data and bacterial genomes in one open platform. #WAAW2025 #ActOnAMR www.ebi.ac.uk/about/news/t... 🧬💻
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- Our new preprint covering the improvements we made to our respiratory metagenomic assay is out now: www.medrxiv.org/content/10.1... ✅ Now implemented in 6 NHS hospitals ✅ Increased sensitivity ✅ Increased pathogen genome coverage (1/3)
- It is an improvement on the method that has been used in botho ur single-centre ICU paper published last month in Lancet Microbe, and the preprint results reported by GOSH in their paediatric intensive care setting: www.thelancet.com/journals/lan... www.medrxiv.org/content/10.1... (2/3)
- Reposted by Ronan DoyleNew research article Estimating the association of antimicrobial resistance genes with minimum inhibitory concentration in Escherichia coli: an observational study www.thelancet.com/journals/lan... #IDSky #ClinMicro #AMR #WGS #OpenAccess #OA
- Reposted by Ronan DoyleNew research article Rapid pan-microbial metagenomics for pathogen detection and personalised therapy in the intensive care unit: a single-centre prospective observational study www.thelancet.com/journals/lan... #IDSky #ClinMicro #OpenAccess #OA
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- Reposted by Ronan Doyle🚨 New preprint! 🧬 𝐏𝐡𝐚𝐠𝐞-𝐩𝐥𝐚𝐬𝐦𝐢𝐝𝐬 (𝐏-𝐏𝐬) are fascinating elements: both 𝐭𝐞𝐦𝐩𝐞𝐫𝐚𝐭𝐞 𝐩𝐡𝐚𝐠𝐞𝐬 and 𝐩𝐥𝐚𝐬𝐦𝐢𝐝𝐬 ➡️ tricky to detect. We present 𝐭𝐲𝐏𝐏𝐢𝐧𝐠 — the first 𝐢𝐝𝐞𝐧𝐭𝐢𝐟𝐢𝐜𝐚𝐭𝐢𝐨𝐧 𝐚𝐧𝐝 𝐜𝐥𝐚𝐬𝐬𝐢𝐟𝐢𝐜𝐚𝐭𝐢𝐨𝐧 𝐭𝐨𝐨𝐥 🛠️designed specifically for P-Ps: ✅ Accurate ✅ Sensitive ✅ Easy to use 📖 www.biorxiv.org/content/10.1...
- Reposted by Ronan DoyleExcited to share a new preprint from the lab with @ryandhindsa.bsky.social ! www.biorxiv.org/content/10.1... Led by @sherrynyeo.bsky.social, @erinmayc.bsky.social, and friends, we continue our journey to find viral DNA in our favorite place-- the overlooked and discarded reads in existing data! 1/
- Reposted by Ronan DoyleAnnouncing myloasm, a new long-read (ONT R10/PacBio) metagenome assembler that I've been working on during my postdoc in the Heng Li lab (@lh3lh3.bsky.social). myloasm-docs.github.io
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- Reposted by Ronan DoyleNext speaker was Luke Blagdon Snell with Same-day pan-microbial metagenomics for personalized therapy and pathogen surveillance on the intensive care unit: a single-centre prospective study (escmid.reg.key4events.com/AbstractList...).
- Reposted by Ronan DoyleRobbie Hammond presented next with Implementing same-day respiratory metagenomic diagnostics in paediatric intensive care (escmid.reg.key4events.com/AbstractList...). Their method had a turnaround time of 6 hours.
- Reposted by Ronan DoyleThis is the updated metagenomics protocol for respiratory samples search.app/V491AEp3tmB7...
- Reposted by Ronan DoyleMicrobiome science needs more microbiologists- A new commentary authored by myself and @abaumler.bsky.social www.nature.com/articles/s41...
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