Yong E. Zhang
Evolutionary geneticist, new gene origination, transposable element
- Reposted by Yong E. ZhangCall for Abstracts Open! The 4th AsiaEvo conference will be held at Kumming, China Dec 8-11 2025. We are organizing Symposium 3 aiming for a broad discussion on organisms’ adaptation under global change, from bacteria to large mammals. Also check other symposium topics that attract you!
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- 1/8 Our new paper w/ Drs. Caixia Gao & Gogo Liu groups reveals how #CRISPR-Cas12 systems evolved from transposon-encoded TnpB nucleases through RNA splitting by analyzing “TranC” systems (evolutionary intermediates bridging selfish elements and adaptive immunity). #Evolution
- 2/8 Phylogenetic mining revealed several young Cas12 clades we call “TranCs”, i.e., nascent CRISPR systems emerging from distinct TnpB lineages. These represent multiple independent domestication events from transposons.
