Noonan Lab
Laboratory of Professor James Noonan | Department of Genetics at Yale University. Science is a team sport. Reposts are not necessarily endorsements. We speak only for ourselves. Website: noonanlab.org
- Reposted by Noonan LabThe conference (agreement between House and Senate) appropriations bill that includes HHS and NIH was released this morning. www.appropriations.senate.gov/news/majorit... 1/5
- Reposted by Noonan LabNIH budget bill out today. It’s the result of heavy negotiations in Congress over past month+. 🧪 Big pic: NIH budget now is abt more than funding. It’s abt restraining the technical ways NIH is being broken by Proj 2025. And the restraints in the bill are tepid 🤷♂️ Also: watch ICE/DHS budget. 🧵1/
- Reposted by Noonan LabCancer research costs too much but we have the money to run Venezuela
- We're truly in the darkest timeline. bsky.app/profile/timb...
- Reposted by Noonan LabI really hate it when scientists keep saying that “we need to rebuild trust in science,” because it implies that scientists are to blame for the mistrust rather than the millions of dollars of dark money that have funded political attacks on science in order to advance a far right agenda.
- Out in Cell Genomics: A comprehensive analysis of the cell-type-specific effects of CHD8 loss of function on gene expression in the embryonic and juvenile mouse cortex. Thread 🧵: www.cell.com/cell-genomic...
- Loss-of-function variants in CHD8 are strongly associated with risk of autism spectrum disorder (ASD) and macrocephaly. Previous studies, including work from our lab, implicated CHD8 in broad gene regulation during neurodevelopment, including the direct regulation of other ASD risk-associated genes.
- Reposted by Noonan LabMost neurodevelopmental disorders are caused by having 1 functional gene copy. Using SCN2A, we show that upregulating the functional copy rescues neuronal phenotypes. Amazing work with @neurobender.bsky.social led by Serena Tamura, Andrew Nelson, Perry Spratt & others. www.nature.com/articles/s41...
- Yale has established a new PhD program in Human Genome Sciences and will be accepting applications this fall. We are also searching for an Associate Director of Student Services (a PhD-level position). Learn more here: medicine.yale.edu/bbs/tracks/h... careers.yale.edu/us/en/job/YU...
- Reposted by Noonan LabCheck out our latest work co-led by @dcsoto.bsky.social and @jmuribescr.bsky.social identifying hundreds of human duplicated gene families using the new T2T-CHM13 assembly, with a focus on those potentially contributing to brain evolution 🧪: authors.elsevier.com/a/1lTQtL7PXu...
- So NIMH is no longer supporting F31s, but is still supporting F30s and F32s? I initially thought this might be an error in the FOA (there are a lot more errors popping up now), but it's in the Guide too: grants.nih.gov/funding/nih-...
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- Reposted by Noonan LabThrilled to share our latest study out in @natureportfolio.nature.com led by the fantastically talented Jing Liu. Our study provides insight into a long standing question in biology: What molecular features make us uniquely human and how do these function? www.nature.com/articles/s41...
- Despite the Times trying to spin this as “Harvard should quit,” the article really (and likely unintentionally) conveys the message “Harvard should absolutely keep fighting.” www.nytimes.com/2025/05/08/u...
- For #FluorescenceFriday, here's a human-chimpanzee iPSC-derived chimeric somitoid, with human cells shown in red and chimpanzee cells shown in green, made by our student Je Won Yang (1/2):
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- Reposted by Noonan LabACTION ITEM-----ACTION ITEM Implementation of Schedule F This is what a lot of us have been worried about. This allows for many civil service positions to replaced with political appointees. This could include NIH institute directors and even POs. BUT THERE IS A COMMENT PERIOD... 1/n
- Glad to see that Yale has co-signed this statement. bsky.app/profile/cant...
- Our own Paschal candle. Happy Easter, everyone.
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- On the futility of collaboration, from Tom Scocca. I'd also like to point out that trust in higher ed and institutional expertise is so low right now in large part because of a decades-long right wing propaganda campaign to achieve exactly that end. defector.com/the-bargain-...
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- Reposted by Noonan LabA project five years in the making, we've now published complete "T2T" genomes for six additional ape species! It turns out that finishing (and analyzing) six genomes is slightly more work than one... doi.org/10.1038/s415...
- Reposted by Noonan LabExclusive: Weeks after President Donald Trump’s administration ordered NIH to pull $250 million in biomedical research grants to Columbia University, the agency is freezing all remaining grant money owed to the university until further notice. scim.ag/4if5Rg1
- Reposted by Noonan LabWe're disappointed to see Ben Barres's powerful book "The Autobiography of a Transgender Scientist" among the ~400 titles removed from the Naval Academy Library. Needless to say, we're proud to have published his book and will keep it — and his memory — alive.
- Cornell is unique among the Ivies in that many of its constituent colleges are effectively part of the SUNY system. Doesn't this give New York State standing to sue the federal government? bsky.app/profile/deni...
- Reposted by Noonan LabNew preprint from my group! Here we studied the contribution of a subset of human- and hominoid-specific transposons (SVA, LTR5HS) to the evolution of human craniofacial development. We specifically focussed on cranial neural crest (CNCC) formation and migration 1/n www.biorxiv.org/content/10.1...
- Reposted by Noonan LabBREAKING: We're suing the National Institutes of Health over their politically-motivated purge of research grants. This is an unlawful attack on scientific progress that puts lives at risk.
- Congratulations to Dr. Atreyo Pal, who defended his PhD thesis today! He is our 11th PhD! You can read all about his work here: www.cell.com/cell/fulltex...
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- Reposted by Noonan LabMy OpEd in @elife.bsky.social “It feels as if we are trying to fight a series of attacks on science with one arm tied behind our back and our lips half sewn shut.” “Yet we are not beaten, and some of us are downright energized.” elifesciences.org/articles/106...
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- These are children. Little girls and boys playing at "government."
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- Reposted by Noonan Lab"Why don't you buy a new centrifuge" Because everyone knows that any appliances in that shade of yellow will outlive you and your entire family, look at it
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- Reposted by Noonan LabHow does gene regulation shape brain evolution? Our new preprint dives into this question in the context of mammalian cerebellum development! rb.gy/dbcxjz Led by @ioansarr.bsky.social, @marisepp.bsky.social and @tyamadat.bsky.social, in collaboration with @steinaerts.bsky.social
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- Reposted by Noonan LabI have confirmation from several sources now that all T32s, many F30s and F31s, and most or all Center awards (P30, P50) have been terminated at Columbia. This is quite damaging to research and to individuals. This is pure terrorism and cannot be legal. But litigation will take time...
- Reposted by Noonan Lab👇🎯 The public isn't going to understand this, unless the presidents of R1 universities around the country <loudly> & <collectively> get out into the public square & start explaining this & calling out the existential threat to the entire 🇺🇸 university system. The silence is deafening right now.
- Reposted by Noonan LabA beautiful blustery day in Hartford Connecticut to gather in support of scientific funding and research. Great that @blumenthal.senate.gov showed up, too!
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- My reading of this is that it will affect every single institutional training grant. Every T32 has a section describing how the program includes efforts to promote diversity. I guess we'll see if T32 NOAs are issued this spring. bsky.app/profile/jere...
- Apparently, program officers (POs) must evaluate each grant and confirm that it complies with the Exec Orders. The objectionable topics include workforce DEIA, gender identity, environ. justice, foreign sites, and Plans for Enhancing Diverse Perspectives) commonfund.nih.gov/humanvirome/... 3/n
- This is grim reading. They are trying to starve the NIH and universities into compliance. The fact that this will also destroy public health, American higher education and will literally kill people is clearly of no concern to them at all. www.theatlantic.com/health/archi...
- Reposted by Noonan LabI talked to NIH officials, current and former, about what's been happening inside the agency since the Trump administration shut down their grantmaking pipeline in January. Their stories showed just how willing our new leaders are to break the law: www.theatlantic.com/health/archi...
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- I guess I'm on the purge list now: bsky.app/profile/dave...
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- Some good advice this Friday that now is not the time to succumb to despair. www.hamiltonnolan.com/p/they-are-a...
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