Nature research paper: Re-adenylation by TENT5A enhances efficacy of SARS-CoV-2 mRNA vaccines
go.nature.com/4cAPx85
Re-adenylation by TENT5A enhances efficacy of SARS-CoV-2 mRNA vaccines - Nature
Upon intramuscular administration, COVID-19 mRNA vaccines are primarily taken up by macrophages, in which the cellular machinery extends their poly(A) tails, thereby increasing mRNA stability and translation, providing an explanation for the efficacy of these vaccines.
