Nature Reviews Endocrinology, Published online: 11 December 2025; doi:10.1038/s41574-025-01222-9The quest to understand the adverse health outcomes linked to endocrine-disrupting chemicals continued in 2025. Insights have been gained regarding their effects on metabolic health, their key characteristics, the mechanisms underlying their effects and the burden of disorders associated with exposure to these chemicals in terms of mortality and life-years lost.