New Article! Single-nucleus chromatin accessibility and gene expression co-profiling by ISSAAC-seq

Single-nucleus chromatin accessibility and gene expression co-profiling by ISSAAC-seq
Nature Protocols, Published online: 12 January 2026; doi:10.1038/s41596-025-01304-yThis protocol describes a flexible workflow for joint profiling of chromatin accessibility and transcriptomes in single nuclei, compatible with either plate or droplet single-cell isolation platforms.