Mike Lacy
I work @addgene.bsky.social curating DNA and web content.
#OpenScience supporter, previously at ASCB, science publishing/preprints.
Yale Biophysics PhD. Opinions my own. He/him
- Reposted by Mike LacyBeen on multiple search committees For me (personally so YMMV)…I basically dismiss everything that’s labeled *submitted* unless there’s a preprint I can read
- Reposted by Mike Lacy[Not loaded yet]
- Reposted by Mike LacySo many developers have sent me that Anthropic skills/mastery case study that I realized I should ungate what I *already wrote* about this: beginning principles to design workflows that work *with* your mind, not against it, & protect your problem-solving www.fightforthehuman.com/cognitive-he...
- Reposted by Mike LacyToday, I would like to honor the memory of Roger Y. Tsien, born on February 1, 1952. His legacy lives with all who use his technologies, including calcium sensors, fluorescent proteins, the acetoxymethyl (AM) ester, & many more! #FluorescenceFriday www.nature.com/articles/nme...
- Reposted by Mike LacyI had intended to post something about this new Google DeepMind paper that appeared yesterday in Nature, but the press coverage has added to what there is to say. So this is a long 🧵 www.nature.com/articles/s41...
- Reposted by Mike LacyMake your gene knockouts more efficient with multiplexed Cas12a sgRNAs. Our new paper is out now, with tools available from @addgene.bsky.social , www.plasmids.eu and @vdrc-flies.bsky.social. www.nature.com/articles/s41... #CRISPR #geneediting #Drosophila 🧪🧬✂️🔬🪰 Summary 🧵 below.
- Reposted by Mike Lacy[Not loaded yet]
- Reposted by Mike LacyGreat news! @mariaingaramo.bsky.social 's company (Nonfiction Labs) made a remote-controlled antibody. Its binding turns on and off with a magnet. This is a HUGE step towards our dream of magnetically controlled drugs. Imagine a cancer drug that ONLY attacks the tumor, not the rest of your body.
- Reposted by Mike Lacy[Not loaded yet]
- Reposted by Mike LacyThis is so grim. Science isn’t just something nerds do, but the foundation of the modern world. What the Trump regime has done to US science will harm Americans for generations.
- Reposted by Mike LacyOne of my concerns with AI-assisted research in biology is that we're already looking only in the lamplight and AI incentivizes us to narrow the beam. Seems like it's happening... www.nature.com/articles/s41...
- Reposted by Mike Lacy[Not loaded yet]
- Reposted by Mike Lacy[Not loaded yet]
- Reposted by Mike LacyIt's easier to tear down than build up, and in science we have a bad case of that. So: how to lead a journal club that actually finds value in what you read. scientistseessquirre... 🧪
- Reposted by Mike LacyPreprints of pandemic potential - new historical piece from me on the history of bioRxiv/medRxiv, their role in the pandemic, and the way forward. 1/n journals.asm.org/doi/10.1128/...
- Reposted by Mike Lacy🔬 🖥️ Applications are open for the CSHL course Quantitative Imaging: From Acquisition to Analysis (April 6–21, 2026)! An intensive, hands-on course covering advanced fluorescence microscopy and quantitative image analysis using open-source tools. 🗓️ Apply online by Jan 30, 2026
- Reposted by Mike LacyGiving the gift of negative data 🥰 Since I joined @lsajournal.org I have handled several stellar manuscripts that report null results. These papers do very well and reviewers almost always appreciate them! Thanks @rockefeller.edu news team for the article! www.rockefeller.edu/news/38829-t...
- Reposted by Mike Lacy[Not loaded yet]
- Reposted by Mike LacyWe recently published a paper in @plosbiology.org We found a lot of problems in animal studies of hemorrhagic stroke. Research integrity folks found the paper but the neuroscience community seems to have missed it completely. I'd like them to read it too! doi.org/10.1371/journal.pbio.3003438
- "We need to stop measuring what's easy to measure and start looking for what's important." - Tony Ross-Hellauer [2021] Example case study: UniProt database saves users €1000s per year in the "time they would have otherwise spent digging up the information from other sources"
- Reposted by Mike LacyA free, open-access library of high-quality organism illustrations for science communication
- Reposted by Mike LacyOn delayed application review, the NIH grant terminations lawsuit appears to be headed for a settlement. Both plaintiffs and defendants have submitted a joint document outlining their agreement. Judge Young must sign off on it before it takes effect. Here's what it says and what all this means 🧵
- Reposted by Mike LacyWe’ve highlighted some wonderful images and researchers in our ‘Featured image’ series in 2025. To celebrate, we’re inviting you to vote for your favourite in our image competition! #FluorescenceFriday Check them out here: focalplane.biologists.com/2025/12/19/v...
- Reposted by Mike Lacy[Not loaded yet]
- Reposted by Mike Lacy[Not loaded yet]
- Reposted by Mike Lacy
- Reposted by Mike Lacy[Not loaded yet]
- Reposted by Mike Lacy[Not loaded yet]
- Reposted by Mike LacyOrganelles do NOT have a single uniform pH. And if you think they must, because “protons diffuse fast,” this paper is for you. A thread on why that assumption is wrong; and what we found instead. 🧵 1/n
- Organelles harbour pH gradients biorxiv.org/content/10.64898/20…
- Reposted by Mike LacyAttendance at US-based science conferences is bouncing around this year but generally down. #AGU25 has ~10k fewer this year! I explored these trends for @nature.com — including solutions to keep conferences local & productive: www.nature.com/articles/d41... 🧪
- Reposted by Mike Lacy[Not loaded yet]
- Reposted by Mike LacyPleased to share this thoughtful essay by Jess on my flower design project🌹🧬 As a small thank-you for spreading the work, I'm randomly giving away 5 of these new morphogenesis hoodies to whoever reposts this!
- Genetic engineering, painting, sculpting, floristry, and fantasy are united in @nickdesnoyer.bsky.social 's flower design art project. New essay out now on a blossoming frontier of transgenic art!
- Reposted by Mike Lacy[Not loaded yet]
- Reposted by Mike LacyThis is excellent: Tips and Tricks for Writing Constructive Peer Reviews Perhaps the most excellent part is this subhead: "Remember that peer review is not meant to crush souls". Right? Peer review should improve papers (and OK, gatekeep a little) - not make an author regret their career choices!
- In my first Editorial as Associate Editor for @conphysjournal.bsky.social, we help combat this lack of training by providing some "tips and tricks" for writing constructive peer reviews, based on our collective experiences as editors for multiple scientific journals.
- Reposted by Mike Lacy[Not loaded yet]
- 👀
- Leaders at @ukri.org should be seriously looking at the lottery first idea. 68% lower economic costs, increase in diversity of award holders and well received. www.nature.com/articles/s41...
- Reposted by Mike LacyLeaders at @ukri.org should be seriously looking at the lottery first idea. 68% lower economic costs, increase in diversity of award holders and well received. www.nature.com/articles/s41...
- Reposted by Mike Lacy[Not loaded yet]
- Reposted by Mike Lacy[Not loaded yet]
- Reposted by Mike Lacy[Not loaded yet]
- Reposted by Mike LacyArrows are tricky. For us, as the designer of the visual, it will be super clear what it means. But for someone looking at our visual for the first time, it can be highly ambiguous. Depending on the reader, the same arrow can mean sequence, zoom, range, label, movement,... 1/2
- Reposted by Mike LacyApplications are open for @dev-journal.bsky.social 2026 Pathway to Independence (PI) programme, supporting postdocs applying for group leader positions: Mentoring Profile raising Leadership training Network building Spread the word... www.biologists.com/grants/devel...
- Reposted by Mike LacyScience question: does your lab have a MinION sequencer and does it work well? Worth the money? (thanks for any opinions!)
- Reposted by Mike LacyHey, what are you gonna get for the office secret Santa? For your mother in law who loves her bird feeder? For your niece who loves whales? For your dad who literally has no hobbies and you’re like “shit wtf do I get this guy”? Get a love notes from nature calendar! squidfacts.net
- Let's gooo! 📣 I'm running the 2026 Boston Marathon as a fundraiser for Boston Children's Hospital! If you're looking for causes to support on #GivingTuesday, I'd be grateful for any contribution: secure.childrenshospital.org/goto/mikelac...
- Reposted by Mike Lacy[Not loaded yet]
- Reposted by Mike Lacy[Not loaded yet]
- Reposted by Mike Lacy[Not loaded yet]
- Reposted by Mike Lacy[Not loaded yet]
- Reposted by Mike Lacy[Not loaded yet]
- Reposted by Mike Lacy[Not loaded yet]
- Reposted by Mike LacyCalling all rising juniors & seniors: Interested in biological or biomedical research? Applications for our ’26 Summer Undergraduate Research Experience Program are now open! Nine weeks, hands-on research, & mentorship from some of the nation’s top scientists — learn more: bit.ly/CechFellows
- Reposted by Mike Lacy[Not loaded yet]
