Mark McMullan
Evolutionary biologist -population genomics -wild-agricultural pathogen evolution, invasion and adaptation (Wheat & Beets)
- Reposted by Mark McMullanWhat enables a fungus to invade a mammal host? @marco-guerreiro.bsky.social unravels signatures of translation adaptation among pathogenic and non-pathogenic species of Trichosporonales. See more: www.nature.com/articles/s41...
- Reposted by Mark McMullanDistribution of Gene Tree Topologies with Duplication, Loss, and Coalescence biorxiv.org/content/10.64898/20…
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- Reposted by Mark McMullanHave we been overstating the role of transposable elements in adaptation to local or rapidly changing environmental conditions? Happy to share my (somewhat unpopular?) opinion paper on this matter: www.sciencedirect.com/science/arti... Thanks to those who already shared the link!
- Reposted by Mark McMullanAre you excited about pangenomics? If so, join us in Edinburgh on 8-9th June to discuss the latest methods & insights from using these approaches across biodiversity! More details here: royalsociety.org/science-even... Organised together with @henrylnorth.bsky.social & @joanameier.bsky.social!
- Reposted by Mark McMullanSpent last week at the microscope 🔬✨, and seeing arbuscular mycorrhizal fungi up close for the first time—hyphae, arbuscules, vesicles—was absolutely mind-blowing. Small but mighty partners of plant roots 🌿. Sharing a few of my favourite shots. #Mycorrhiza #fungi
- Reposted by Mark McMullanBig congratulations @tobybarilbio.bsky.social! Please check out and share our final version of the transposon mobilization work in a fungal pathogen - out now in Nature Communications www.nature.com/articles/s41...
- TEs aren’t just genomic parasites, they’re also engines of genomic novelty. Our new study with ~2,000 Z. tritici genomes shows repeated TE mobilization waves during global expansion. With @danielcroll.bsky.social & @guidopuccetti.bsky.social 🧬 www.nature.com/articles/s41... #TEworldwide
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- Reposted by Mark McMullan@tobybarilbio.bsky.social and I are very excited to release MycoMobilome! A very extensive effort to discover, QC and annotate TEs across the fungal kingdom. 👉 Ready-to-use for your own genome with a simple tutorial! 👉 Metadata about TEs discovered in your genome! 👉 Contribute and get recognition!
- 1/ Ever needed to annotate TEs in a fungal genome, but didn't know where to start? We have released #MycoMobilome, a community-focused non-redundant database of transposable element consensus sequences for the fungal kingdom, constructed from >4,000 fungal genomes! www.biorxiv.org/content/10.1...
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- Reposted by Mark McMullanWe are advertising a PhD project investigating a cellular mechanism that ensures protein quality control during mRNA translation in plants. Please get in touch on here or via email if you are interested and I can provide further details! Lab website: sites.google.com/site/danielg...
- Reposted by Mark McMullanGreat new postdoc fellowship for foundational plant research. If you’re into genetics and genomics of plant reproductive evolution or adaptive convergence (incl in the cool and charismatic nightshades!) I’d be happy to talk about possible projects! www.simonsfoundation.org/grant/simons...
- PhD studentship Come help us understand the wheat rhizosphere at the Earlham Institute 🦠 Working at the interface of fungal antagonists & pathogens (@rowenahill.bsky.social @neilhall.bsky.social ), host genetic diversity (Simon Griffiths -JIC) and bacterial community diversity (Jacob Malone -JIC)
- Working alongside colleagues at @earlhaminst.bsky.social , @johninnescentre.bsky.social , @dsw-isp.bsky.social , @norwichmicro.bsky.social , and @rothamsted.bsky.social. Do get in touch to find out more
- Reposted by Mark McMullanProfessorship in plant genetics. The Botanical Institute at Kiel University is advertising a W2 professorship. Great opportunity to do plant research in the north of Germany. See: www.berufungen.uni-kiel.de/de/dateien/o...
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- Reposted by Mark McMullanIt was a delight to have Guillaume Delhaye and Torda Varga (@rbgkew.bsky.social) at @earlhaminst.bsky.social last week, talking to a packed Norwich Research Park audience about mushroom-forming and mycorrhizal fungi from molecule to ecosystem! 🍄🧬🌳 @neilhall.bsky.social @norwichmicro.bsky.social
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- Reposted by Mark McMullanHow predictably does complex trait adaptation proceed over space and time in wild populations? doi.org/10.1093/evle... Now in @evolletters.bsky.social by @skylerberardi.bsky.social, @paulrschmidt.bsky.social et al. 📷: Dr. Rush Dhillon
- Reposted by Mark McMullanAdvances in computational methods for inferring networks from #genome-scale data and guidelines for deriving biological insights from #phylogenetic networks www.pnas.org/doi/10.1073/...
- www.nature.com/articles/s41... Really nice. Especially nice RIP result linked to ancestral sex hypotheses. Which then links nicely to plastic genomic regions and adaptation in the face of asexual reproduction.
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- Reposted by Mark McMullanOur paper on phylogenetics of fungal Starship TEs is now on the cover of the June issue of Genetics @genetics-gsa.bsky.social 🙂 academic.oup.com/genetics/iss... @mcmullan0.bsky.social @earlhaminst.bsky.social @rothamsted.bsky.social
- Starship giant transposable elements cluster by host taxonomy using k-mer-based phylogenetics. #TransposableElements #TEs #Kmer #Phylogenetics #Genomics #Bioinformatics #G3 🧬 🖥️ academic.oup.com/g3journal/ad...
- Reposted by Mark McMullanWhile helping out on a cool genomics project recently, I came to realise I’d been taught a pretty big inaccuracy about the events that occur at fertilization. I suspect that almost everyone reading this has the same misapprehension, so let’s do some learning together: 1/
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- Kmer based phylogenetic methods like Mashtree (@lskatz.github.io), are really powerful for difficult to align and repetitive regions including TEs, Integrative and conjugative elements & Starships etc. Really nice work from @rowenahill.bsky.social and thanks to collaborators @rothamsted.bsky.social
- Our recent paper is out where we propose kmer-based phylogenetics for fungal Starship TEs (which are unalignable as highly variable). We think it could help with spotting bonafide HGT events (and suggest direction of transfer?) doi.org/10.1093/g3jo... @mcmullan0.bsky.social @norwichmicro.bsky.social
- Thanks for posting @reviewcommons.org If you're interested you can also find the reviewed version here: doi.org/10.7554/eLif... Really keen to get people's perspectives on the population genetics of reservoirs, and what they tell us about variation associated with emergent crop pathogens.
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- Reposted by Mark McMullanExcited to share our latest preprint 🥳 Historic transposon mobilisation waves create distinct pools of adaptive variants in a major crop pathogen @danielcroll.bsky.social #TESky www.biorxiv.org/content/10.1...
- Reposted by Mark McMullanThose trying to understand the tariffs as economic policy are dangerously naive. No, the tariffs are a tool to collapse our democracy. A means to compel loyalty from every business that will need to petition Trump for relief. 1/ A 🧵 to explain his plan and how we fight back.
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- Reposted by Mark McMullanHappy to share that our paper "Analyses of Transposable Elements in Arbuscular Mycorrhizal Fungi Support Evolutionary Parallels With Filamentous Plant Pathogens" is out. academic.oup.com/gbe/article/...
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- This the second in a clutch of papers that start to look at the genome biology of virulence of this important wheat pathogen (@dsw-ISP.bsky.social). Here detailing methods for extracting fungal DNA for @pacbio.bsky.social HiFi T2T genomes when melanin is an issue. Well Done.
- Reposted by Mark McMullan🆕 Fully funded #PhD with @neilhall.bsky.social and @mcmullan0.bsky.social analysing genetic diversity in the genomes of potential crop invasion pathogens and plant hosts associated with resistance. 📆 Apply by: 21 April ➡️ buff.ly/RpmTSFN #plantscience #agritech
- Reposted by Mark McMullanMe on the radio this morning talking about UK preparedness for #xylella, froghoppers and the BRIGIT project in the @saskiahogenhout.bsky.social lab @johninnescentre.bsky.social www.bbc.co.uk/sounds/play/...
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- Reposted by Mark McMullanThe final version of our paper on genomics of understudied fungal root pathogens/endophytes of wheat is now out! The result of close ongoing collab between @earlhaminst.bsky.social (@mcmullan0.bsky.social @greymj.bsky.social @neilhall.bsky.social et al) and @rothamsted.bsky.social rdcu.be/edlB9
- This is the first in a clutch of papers that start to look at the genome biology of virulence of this important wheat pathogen (@dsw-isp.bsky.social). Here dipping into RIP, gene copy number variation, biosynthetic gene clusters, and giant cargo mobilising elements (Starships). Well done.
- The final version of our paper on genomics of understudied fungal root pathogens/endophytes of wheat is now out! The result of close ongoing collab between @earlhaminst.bsky.social (@mcmullan0.bsky.social @greymj.bsky.social @neilhall.bsky.social et al) and @rothamsted.bsky.social rdcu.be/edlB9
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