Maria Puschhof
Computational Scientist at HI-STEM / DKFZ.
Heterogeneity in cancer | Computational Biomedicine
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- Reposted by Maria PuschhofI wrote a short piece on how becoming an IgA Nephropathy patient has changed my perspective on biomedical research, developing an appreciation for the challenges in data interpretability & availability and the importance of patient engagement www.nature.com/articles/s41...
- Reposted by Maria PuschhofHow does tumour heterogeneity arise? How can we predict cancer cell plasticity? In 2 new studies, we trace #glioblastoma heterogeneity to a spatial cancer cell trajectory w. multimodal cell atlassing bit.ly/4mkrWgs & predict plasticity w. snRNA/ATAC+deep learning bit.ly/3FbI6Ic 🧵
- Reposted by Maria Puschhof🧠 Excited to share my main PhD project! We mapped the regulatory rules governing Glioblastoma plasticity using single-cell multi-omics and deep learning. This work is part of a two-paper series with @bayraktarlab.bsky.social @oliverstegle.bsky.social and @moritzmall.bsky.social, Preprint at end🧵👇
- Reposted by Maria Puschhof🎗️On #RareDiseaseDay, we raise awareness for #MYT1L Syndrome, a rare #autism-associated disorder disrupting brain development. Our research at DKFZ, ZI, and Heidelberg University Hospital shows an epilepsy drug may help—future trials ahead! 📑 www.nature.com/articles/s41... 🎥 youtu.be/nYqNEPIOc-8?...
- Reposted by Maria Puschhof#CellPlasticity—the ability of cells to change their identity—is vital for tissue growth and repair. But when it goes unchecked, it can fuel #cancer. Our latest study examines how to block #LiverCancer by actively suppressing plasticity. www.nature.com/articles/s41... #CancerBiology
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- Reposted by Maria PuschhofInterested in our research? We've created a starter pack so you can now follow our current lab members and alumni. Be sure to check it out! 🥳at://did:plc:gek7noi4bxklrhxyaiy625og/app.bsky.graph.starterpack/3ldlsdelctj2v
- Hyped to be at the #ESSB #spatial #biology conference together with some of my colleagues from the @saezlab.bsky.social . Great science, beautiful venue, looking forward to the next 1.5 days...
- Reposted by Maria PuschhofWe are looking for a Postdoc with a strong computational background to join our team. Want to work on the development and application of computational methods in the field of translational spatial biology? Apply now! karriere.klinikum.uni-heidelberg.de/index.php?ac...
- Reposted by Maria PuschhofVery pleased to announce that our package for Multiscale Spatial Analysis - MuSpAn - has landed! The preprint is on biorxiv now, but you can find a lot more details at www.muspan.co.uk, including documentation, worked tutorials (an ever-expanding list), install guides, and how to get the code!
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- Great to see the study published! Congrats to all co-authors and thanks very much for having us @juliosaezrod.bsky.social @saezlab.bsky.social on the team. A nice example of how the @aihcluster.bsky.social makes new collaborations possible.
- 🧵Just in time for : New research from the Venkataramani lab @CellCellPress maps how brain tumor cells create extensive neural networks in glioblastoma. Check out our paper here: authors.elsevier.com/sd/article/S... @ekinreyhan.bsky.social @svenjaktetzlaff.bsky.social 1/15
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- Reposted by Maria PuschhofWe present NetworkCommons, a unified platform 🪐 for network biology, providing access to omics data, knowledge, and contextualization methods, all with a consistent API 👇🧵 Paper: doi.org/10.1101/2024... Docs: networkcommons.readthedocs.io
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