Madeline Lancaster
Developmental neurobiologist using cerebral #organoids to study brain size and evolution. Opinions my own.
- Thank you for this important paper! Using biobanks of thousands of people to check what effects archaic coding variants might have. Finding certain variants in healthy modern humans helps clarify which might have real consequences to human evolution, and which do not.
- This is a great article and you can read it free here! A fresh perspective to understanding language with an interdisciplinary and integrative approach.
- Just got @philipcball.bsky.social’s book, can’t wait to dig in!
- Cool paper and cool thread! Makes me wonder, what’s going on in a whale or dolphin brain where there’s essentially no layer 4 🤔
- A core function of cortex is predicting what happens next given the world's state. This recent paper from Oxford shows how cortical layers may use a delay trick to learn to predict. A simple illustration can explain the idea. A🧵with my toy model and notes: #neuroskyence #compneuro #NeuroAI
- Super excited for the start of #EESorgan 2025! One of my favorite parts of coming to EMBL is the walk to the ATC through the forest. Can’t wait for 4 days of awesome organoid science!
- Reposted by Madeline LancasterWe are recuiting two new Associate Professors here in Oxford Biochemistry. Come join us! Reach out to me if you have any questions. Please repost! tinyurl.com/mr3m7bd3
- Reposted by Madeline LancasterNew paper alert! Rare DNA changes in the SETBP1 gene are linked to speech problems & diverse syndromes affecting brain development. Work led by ace postdoc @maggiemkwong.bsky.social uncovered impact of different gene variants, coupling clinical/speech evaluation to molecular & cellular readouts.🧬🗣️🔬🧪
- Reposted by Madeline LancasterThe Vienna BioCenter PhD Program application deadline is approaching: October 10! Join one of Europe’s premier life science campuses, home to cutting-edge research across all areas of biology. Apply and start your scientific journey in Vienna! training.vbc.ac.at/phd-program/ #PhD #LifeSciences
- Love RNA biology? Join us to explore the piRNA pathway with structural and genetic approaches (see 👇👇). PhD student/postdoc position co-supervised by Clemens Plaschka & myself. DM or email us if you’d like to know more! @vbcscitraining.bsky.social @imbavienna.bsky.social @impvienna.bsky.social
- Reposted by Madeline LancasterInterested in the mechanisms of neurogenesis, and how they might converge/differ across species, regions, and life epochs? Check this out, wonderful location and great science! Please RT neuro-unige.ch/news/csf-mee...
- Reposted by Madeline Lancaster🚨 Excited to share the latest preprint form the lab ➡️https://tinyurl.com/32d3be9f Here we tackle a long-standing chicken-or-egg 🐣🥚question in #autism and developmental neuroscience ➡️ Is excitation–inhibition (E:I) imbalance a "cause" or a "consequence" of #autism? Check out what we found! 🧵1/n
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- Amazing work! The Silver lab is on a roll!
- Sharing our newest study led by the incredibly talented @federicamosti.bsky.social investigating new molecular mechanisms of human brain development. We discover a human-specific enhancer HAR1984 that influences chromatin looping to promote cortical size and folding! www.biorxiv.org/cgi/content/...
- This new preprint looks pretty interesting. Human neurons take up to 4 decades to fully mature!
- Reposted by Madeline LancasterDelighted & excited to share our latest preprint on non-canonical enhancers in human pluripotent stem cells, the result of a fantastic and fun collaboration with @guenesdoganlab.bsky.social: www.biorxiv.org/content/10.1... 🧵 below
- This is amazing. Really interesting science made accessible to non experts. I recommend tuning in if you can, even for a little while
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- This is so cool! It’s beautiful to see exactly the kind of elegant genetic locus swapping experiments I’ve been hoping to see in the field 🤩 Nice work Debby and team!
- Thrilled to share our latest study out in @natureportfolio.nature.com led by the fantastically talented Jing Liu. Our study provides insight into a long standing question in biology: What molecular features make us uniquely human and how do these function? www.nature.com/articles/s41...
- Check out this impressive work from the Jabaudon lab exploring an age old question: how does the forebrain grow more than the rest of the brain?
- Why does the forebrain expand dramatically while other neural regions grow less? Our new publication reveals progenitor metabolism critically shapes region-specific brain growth. Thread below. authors.elsevier.com/a/1k-udL7PXu...
- So many exciting papers and preprints in the past few weeks. This one is quite the tour de force!
- Exciting work from the Albert lab on unique signatures of human basal radial glia. And look at those beautiful organoids with their basal progenitors! 🤩
- 💫 New preprint from the lab: Comparing great ape cerebral organoids, we found that human-specific morphoregulatory signatures in basal radial glia characterise neocortex evolution. Fantastic work from super-talented PhD student Theresa Schütze! www.biorxiv.org/content/10.1...
- Interesting new work from the McDole lab on the extreme stress primordial germ cells have to endure on their journey to the gonads during embryonic development. It’s wild that a new generation is even possible after all that! www.biorxiv.org/content/10.1...
- In case you missed it, check out our recent preprint on developmental timing and how slower means bigger, axons that is! Led by the extraordinary @felinewlindhout.bsky.social www.biorxiv.org/content/10.1...
- Reposted by Madeline LancasterA couple of weeks left to apply to join Development's *Pathway to Independence* programme Support & mentoring for post-docs on the academic job market Deadline: January 31 journals.biologists.com/dev/pages/pi...
- It’s been an exciting holiday season for the Lancaster Lab, with not 1, not 2, but 3 new preprints to share! Check ‘em out: doi.org/10.1101/2024... doi.org/10.1101/2024... doi.org/10.1101/2024... Happy holidays and best wishes for 2025 from our lab to yours! 🎄🎉
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