Katherine Horton
Infectious disease epidemiologist | Assistant Professor in #TB modelling @lshtm.bsky.social | Mama to 👦👦👦🐶
- Reposted by Katherine HortonPhD position (London, UK) Real-time modelling of infectious disease outbreaks. with @sbfnk.bsky.social @anne-cori.bsky.social @seabbs.bsky.social at @epiforecasts.io @cmmid-lshtm.bsky.social More details: iddjobs.org/jobs/2440
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- All are welcome to join the Gender Equity in TB Working Group today at 12:30 in Room B4B @theunion.org! We'll share updates on working group activities and host a panel discussion on progress to date and ways forward to ensure an equitable and inclusive #TB response.
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- Reposted by Katherine Horton🚨Fully-funded PhD opportunity!🚨 Interested in researching how to improve risk prediction for people with #tuberculosis #TB and #multimorbidity? Joint project between @uofgshw.bsky.social 🏴 and @ki.se 🇸🇪, funded by UK MRC. Details here⬇️ www.gla.ac.uk/postgraduate...
- Interested in #TB, equity, and modelling? @reinhouben.bsky.social and I are advertising an MRC LID studentship on heterogeneity in the coverage of community screening for TB @lshtm-tbmod.bsky.social @lshtm.bsky.social. For more details, visit mrc-lid.lshtm.ac.uk/2026-27-proj...
- Many thanks to @theunion.org and @the-independent.com for highlighting our work estimating the impact of reductions in global health funding on #TB morbidity and mortality @lshtm-tbmod.bsky.social @tb-lshtm.bsky.social
- Ahead of The Union World Conference on Lung Health, Katherine Horton provides @the-independent.com with insights into the devastating impact of the funding cuts on global health, particularly tuberculosis. Be sure to read about the threat of UK aid cuts: www.independent.co.uk/news/uk/poli...
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- Reposted by Katherine HortonWhen fluoroquinolone resistance status is unknown, empirical use of BPaLM (adding moxifloxacin to BPaL) is cost-effective as a replacement for BPaL even with high fluoroquinolone resistance levels! 🦠💊 doi.org/10.1371/jour...
- Reposted by Katherine HortonOur framework that informed the @who.int TB & climate change policy brief out now in @lancetrespirmed.bsky.social, exploring the intersections and implications of climate change for the TB epidemic. Key message? TB should be considered a climate-sensitive disease www.thelancet.com/journals/lan...
- It was a real pleasure to deliver this Introduction to TB Modelling workshop for representatives from Kenya’s National TB, Leprosy and Lung Disease Programme last week with great discussions about how modelling can be used in policy and programme decisions.
- Understanding patterns of #TB exposure and transmission is needed for targeted prevention strategies. In our latest pre-print, @petedodd24.bsky.social and I estimated the proportion of TB exposure to and transmission from sex and age groups for 177 countries. bit.ly/4nbV492
- Both exposure and transmission were higher in males than in females. We found that a majority of TB transmission was attributable to contact with adult men: 67% (95% UI 62-71%) of transmission to men, 52% (95% UI 49-56%) to women, and 63% (95% UI 58-68%) to children. [NOT YET PEER REVIEWED]
- Reposted by Katherine HortonIn a new preprint (NOT PEER REVIEWED) we continue to explore the challenge of overtreatment in community screening. It seems the benefits of TB treatment far outweigh the harms, especially once we accept that sputum culture is not perfect. Important food for thought. www.medrxiv.org/content/10.1...
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- Our systematic review of rural/urban differences in #TB prevalence shows evidence of rapidly urbanising epidemics in many settings, with differences across countries and regions. Link to preprint below ⬇️
- Are there more people with #TB in cities or rural areas? In a 🚨new🚨 preprint (NOT PEER REVIEWED) we modelled urban-rural TB trends from 2000-2023 in 26 countries with 4.6 billion people. www.medrxiv.org/content/10.1...
- Reposted by Katherine HortonSad (but not surprised) to read the latest Global Health 50/50 report, amidst turmoil in global health, erosion of democracy, withdrawal from multi-lateralism, aid cuts, attacks on science, DEI, human rights @kentbuse.bsky.social @jocalynclark.bsky.social global5050.org/2025-report/
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- 1/ It’s been 10 years (😮) since we reported that #TB prevalence was twice as high in men as in women. 📢 Our new preprint explores how sex differences have shifted with more recent national prevalence surveys and growing attention to #gender responsive TB prevention and care. bit.ly/4gqP1LH
- 2/ We updated our systematic review and identified 99 TB prevalence surveys reporting sex-disaggregated results (with >4 million participants) conducted between 1993 and 2024 in 33 low- or middle-income countries. NOT PEER REVIEWED
- Fantastic work from @aschwalbc.bsky.social now out in @plosglobalpublichealth.org. Check out his thread below for more details!
- Our work on modelling population-wide screening in Viet Nam is now available in PLOS Global Public Health! tinyurl.com/3ymhuj5s
- Reposted by Katherine HortonNutritional status is a key determinant of TB. In this updated systematic review and dose-response meta-analysis (43 cohorts inc > 26 million people) we redefined the relationship between body mass index (BMI) and TB. doi.org/10.1093/ije/...
- At a time when global resources for #TB research, development, prevention, and care are limited, which interventions should be prioritised in high burden settings? 📢 Our new pre-print compares the impact, cost, and cost-effectiveness of 9 TB interventions in 3 countries. 1/n bit.ly/3V3vXth
- We developed a deterministic #TB model for a geographically and epidemiologically diverse set of countries, incorporating key structural determinants: incarceration in Brazil, undernutrition in India, HIV in South Africa. We calibrated to epidemiological indicators and trends for each country. 2/9
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- Community screening for #tuberculosis could extend the reach of #TB services, but evidence on its effectiveness is limited. In our latest preprint, we examine the epidemiological impact of trade-offs in diagnostic algorithm, population coverage, and duration of screening. 1/n bit.ly/3UK7pFD
- We used mathematical modelling to evaluate algorithms targeting three disease thresholds: symptomatic TB (by cough w/ confirmatory Xpert Ultra), infectious TB (by Xpert Ultra), or all TB (incl. non-infectious TB, by CXR) at different population coverage levels (10-100%) and durations (1-5 yrs). 2/n
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- New WHO policy brief on #TB among populations at high risk and people in vulnerable situations includes (for the first time!) "men in settings where health care access is not tailored to their needs". www.who.int/publications...
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- Our work estimating the potential impacts of reductions in international donor funding for #TB is now out in @lancetgh.bsky.social: bit.ly/3TDl28T @raclark18.bsky.social @cfmcquaid.bsky.social @alexandra-richards.bsky.social @top-j.bsky.social @reinhouben.bsky.social @richardwhite321.bsky.social
- #Tuberculosis prevention and care relies heavily on international donor funding in many settings. In our latest preprint, we examine the potential impact of reductions in international donor funding for #TB - by the US and by other major donor countries. 1/8 www.medrxiv.org/content/10.1...
- In our latest personal view in @lancetrespirmed.bsky.social, we argue for the inclusion asymptomatic #tuberculosis in vaccine trial endpoints to potentially reduce the size, length, and cost of trials. doi.org/10.1016/S221... @lshtm-tbmod.bsky.social @tb-lshtm.bsky.social
- Co-authored by @richardwhite321.bsky.social Gavin Churchyard @kchorton.bsky.social Andrew Fiore-Gartland @mbehr-mcgill.bsky.social @raclark18.bsky.social @agbasteiro.bsky.social @emilybethwong.bsky.social @reinhouben.bsky.social and many others who don't appear to be on Bluesky
- New systematic review led by @hannahrickman.bsky.social shows annual risk of Mycobacterium #tuberculosis conversion in men and women diverges during adolescence and remains higher among men throughout adulthood. www.thelancet.com/journals/lan...
- NEW STUDY! 📣 A large global study found men are more likely to be exposed to TB than women. The reason? Likely social behaviours: • More time in crowded indoor spaces • Delays in seeking care READ MORE ⤵️ 🔗 www.thelancet.com/journals/lan... @petermacp.bsky.social @hannahrickman.bsky.social
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- Reposted by Katherine HortonTuberculosis (TB), an infectious disease caused by bacteria, was responsible for as many as one-quarter of all deaths in the US and Europe during parts of the 18th and 19th centuries. However, as we see in the chart for England and Wales, deaths from TB have declined dramatically in rich countries.
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- Reposted by Katherine HortonHow bad will it be? Catastrophic. Proposed cuts to #NSF, #NIH, and #NASA will set the US R&D landscape back 25 yrs+, cause economic and job loss now, and undermine innovations to come. But, this is the WH's *proposed* budget. Speak up now before it is too late. (inflation adjusted $-s below)
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- Reposted by Katherine HortonTB & climate change: @who.int report out now, building on an analytical framework we developed to explore the intersections and implications for the TB epidemic. Key message? TB should be considered a climate-sensitive disease www.who.int/publications...
- 🎉 Celebrate 25 years of the Introduction to Infectious Disease Modelling course @lshtm.bsky.social in June! 🎉
- Can you believe it’s already been 25 years!? Come join us on 20 June 2025 at 4pm UK time to celebrate the 25th anniversary of the Introduction to #Infectious Disease #Modelling course delivered by @lshtm.bsky.social and @ukhsa.bsky.social! More info 👉 www.lshtm.ac.uk/newsevents/e...
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- Reposted by Katherine HortonAre you interested in #TB and have experience in #modelling infectious diseases? Come join us in the TB Modelling Group at #LSHTM! We're advertising for a 1 year Research Fellow position, with a closing date of 30 May 2025 👉 jobs.lshtm.ac.uk/vacancy.aspx...
- New pre-print on perceptions of #gender equitable norms and #TB testing history in Malawi, led by @elizabeth-digi.bsky.social with @esnightingale.bsky.social @petermacp.bsky.social Helena Feasey, Rebecca Soko, Vincent Phiri, Liz Corbett @kchorton.bsky.social www.medrxiv.org/content/10.1...
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