Jeff Saucerman
Professor of Biomedical Engineering and Cardiovascular Medicine at UVA. Systems biology to discover drugs for heart disease. Hiking with my dog in Shenandoah NP, around Charlottesville. engineering.virginia.edu/faculty/jeffrey-sau…
- Happy New Year! Just 5 days until the 4th Netflux and Network Biology Virtual Conference on Jan 7, 1-5 pm ET. Please share. Agenda and free registration at: tinyurl.com/netfluxnet2026
- Reposted by Jeff SaucermanAccepted ms on modeling human atrial disease posted @dev-journal.bsky.social just now. Congratulations to @irfankathiriya.bsky.social @jsauce7.bsky.social and team! @gladstoneinst.bsky.social @ucsfanesthesia.bsky.social journals.biologists.com/dev/article-...
- Snowy hike to Hawksbill Summit, Shenandoah NP
- Always fun collaborating on networks of cardiac development with Irfan, @benoitbruneau.bsky.social, and team!
- The 4th Netflux and Network Biology Virtual Conference is coming, Jan 7! Talks on network modeling across methods and biological systems. Free! tinyurl.com/netfluxnet2026
- Winter wonderland 🥾❄️
- Announcing the 4th Netflux and Network Biology Virtual Conference, Jan 7! Free registration and abstract submission (Dec 12). Live demo of the new user-friendly Netflux webapp, student talks, keynote by Suzanne Gaudet (Novartis): bit.ly/4i1eQD6
- Sauce lab dressed for Halloween as favorite proteins! 🎃👻🕷️. I was a serotonin receptor bound to LexaPro for Taylors recent paper.
- Rain fog and leaves turning along Riprap. One of my favorite trails in Shenandoah NP. #hiking
- How do signaling pathways differentially control cell size vs. shape? In a new preprint led by Alice Luanpaisanon, we iterate between experimental and computational methods to discover such pathways. 1/ www.biorxiv.org/content/10.1...
- Spooky fall day in Shenandoah NP
- Paradoxically, heart failure involves both cell death and growth. How does a cell decide? In a paper at JMCC Plus led by Bryan Chun and Lavie Ngo, we find that rather than dying following hypertrophy, stressed cardiomyocytes commit early to either grow or die. www.sciencedirect.com/science/arti...
- Nearing sunset, Shenandoah NP #cville
- @j-muncie-vasic.bsky.social and @benoitbruneau.bsky.social show that MEF2C is not a one trick pony- it distinctly regulates different regions of heart tube formation. Glad @aclark.bsky.social and I could contribute gene regulatory networks that predict mechanisms.
- Happy to share our latest preprint, "Network Modeling Predicts How DYRK1A Inhibition Promotes Cardiomyocyte Cycling after Ischemic/Reperfusion Injury", in collaboration with Matthew Wolf's lab, led by Bryce Murillo and Alex Young! www.biorxiv.org/content/10.1...
- Cooling off at Sugar Hollow #cville
- Sunset showers at Shenandoah NP
- Do large language models understand how cells work? To find out, we built a pipeline that generates logic-based models of signaling networks using general purpose LLMs GPT, Gemini, or Claude. We benchmarked LLM-generated networks against 3 large-scale literature-curated and validated networks. 1/
- Great interactions, crabcakes, and science at #BCVS2025 in Baltimore
- On my way to AHA #BCVS25 in Baltimore! Come see Bryce Murillo present on a drug for DYRK1A that induces cardiomyocyte cell cycling in network models, isolated cardiomyocytes, and after myocardial infarction. Wed 9:39 am.
