Jonathan Bohlen
Group leader at the Gene Center in Munich. RNA biology and protein translation in Immunity. Looking for excited and motivated students!
Dad in Science, He/His Bohlenlab.com
- Reposted by Jonathan BohlenComplete and partial forms of X-linked MCTS1 deficiency in patients with mycobacterial disease. New study by Qinhua Zhou (Fudan University), Jacinta Bustamante @institutimagine.bsky.social, Jonathan Bohlen @jonathanbohlen.bsky.social @lmumuenchen.bsky.social & colleagues rupress.org/jhi/article/...
- New paper in the Journal of Human Immunity! We report complete and partial forms of X-linked MCTS1 deficiency in patients with mycobacterial disease -- four new families from Iran, Oman, China, and the USA. doi.org/10.70962/jhi...
- Building on our 2023 paper, we identified three new MCTS1 variants, including the first hypomorphic variant (p.W175*). Even partial loss of MCTS1 translation reinitiation activity can cause susceptibility to mycobacteria.
- JHI @jhumimmunity.org is the journal of the primary immunodeficiency societies worldwide, hosted by Rockefeller University Press. Open access: doi.org/10.70962/jhi... With Qinhua Zhou, Jacinta Bustamante, Jean-Laurent @casanovalab.bsky.social , and colleagues from six countries.
- Reposted by Jonathan BohlenX-linked MCTS1 deficiency causes susceptibility to mycobacterial disease. In @jhumimmunity.org, Zhou et al. show that report 4 new patients carrying 3 previously undescribed truncating or loss-of-expression variants, presenting w/ BCG disease or M. abscessus infection. rupress.org/jhi/article/...
- Reposted by Jonathan BohlenX-linked MCTS1 deficiency causes susceptibility to mycobacterial disease. Zhou, Bustamante, Bohlen et al. show that report 4 new patients carrying 3 previously undescribed truncating or loss-of-expression variants, presenting w/ BCG disease or M. abscessus infection. rupress.org/jhi/article/...
- Our lab website is live! 🥳 We study how mRNA translation controls immune cell function and how defects in the protein synthesis machinery cause human disease. Come say hello and learn about what we do at the Gene Center Munich. bohlenlab.com
- Reposted by Jonathan BohlenActive transport of tRNAs facilitates distributed protein synthesis biorxiv.org/content/10.64898/20…
- Reposted by Jonathan Bohlen🙌 Herzlichen Glückwunsch! @jonathanbohlen.bsky.social und Jiamin Hou wurden von der @dfg.de im Rahmen des Emmy Noether-Programms ausgezeichnet. Die Fördersumme beträgt jeweils 1,85 Mio. Euro für einen Zeitraum von sechs Jahren. #LMUMuenchen #Astrophysik #Molekularbiologie www.lmu.de/de/newsroom/...
- I don't want to be a huge stickler and I actually really like this paper, congrats to the authors for the nice work. But isn't the use of human eyes in the graphical abstract rather misleading for a paper that contains entirely mouse experiments?
- Commensal-derived trehalose monocorynomycolate triggers γδ T cell-driven protective ocular barrier immunity #gdTcells @cp-immunity.bsky.social
- 🥳 We are excited to share the first publication from the Bohlen Lab! "Somatic deficiency of the human E3 ubiquitin ligase CBL in leukocytes impairs B but not T cell development and function" www.nature.com/articles/s41... together with the Tangye Lab and @bloodgenes.bsky.social and many more! 1/n
- We studied patients with somatic CBL deficiency. These patients often have transient myeloproliferation in childhood, and as we published recently (www.jci.org/articles/vie...) chronic autoinflammation. We noticed that our cohort of CBL deficient patients had a high rate of severe infections. 2/n
- CBL deficient mice have defects in T cell development and function. Yet, surprisingly, the CBL deficient T cells of the patients were largely unaffected. Conversely, B cell development was strongly perturbed. 3/n
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View full threadHuge thanks also to all the amazing collaborators and colleagues all around the world, who made this happen. Finally, many, many thanks to the patients and their families for supporting and enabling our research. fin/n
- Honored to get this opportunity to build out my team and explore molecular immunology!
- 🥳🥂Huge congratulations to Jonathan Bohlen on being awarded an Emmy Noether Grant by @dfg.de 😊🤩 His project addresses a central open question in immunology: how mRNA translation governs the function of T cells. www.genzentrum.uni-muenchen.de/news-events/... @jonathanbohlen.bsky.social
- Reposted by Jonathan Bohlen📣Publication alert! A team led by Roland Beckmann shows: Ribosome collisions activate the kinase ZAK and thus trigger the ribotoxic stress response — a key mechanism of the cellular stress defense. More about it here👇 www.lmu.de/en/newsroom/...
- Reposted by Jonathan BohlenHow does the kinase ZAK sense ribosome collisions? Find out in our latest collaboration with the @greenlab.bsky.social @doubleshuang.bsky.social @Vienna Huso: 1/4 rdcu.be/eRmJl #ribosome #cryoEM #LMU #JHMI
- Reposted by Jonathan BohlenWhipple's disease was an inflammatory condition for decades, it became an infectious disease some years ago, and it is now becoming a genetic disorder: IRF4 haploinsufficiency in a multiplex family with Whipple’s disease url: rupress.org/jhi/article/...
- Reposted by Jonathan BohlenIn less than 8 months, @jhumimmunity has published 56 papers (rupress.org/jhi), including 10 already on PubMed (pubmed.ncbi.nlm.nih.gov?term=j+hum+i...). Please submit studies of human inborn errors of immunity and their phenocopies (rupress.org/jhi/article-...) !
- We report a 5'UTR variant in YEATS4 that confers resistance to tuberculosis through altering the translation of the YEATS4 open-reading frame! Congrats to Clement Conil and colleagues at @casanovalab.bsky.social! It was fun to help with this story! link.springer.com/article/10.1...
- Reposted by Jonathan BohlenNew in @jhumimmunity.org: Tristan van der Linden, András Spaan et al. describe and characterize six unrelated patients with #OTULIN #haploinsufficiency, in whom severe #necrosis followed infectious and/or traumatic triggers. rupress.org/jhi/article/... #Staphylococcus #Ubiquitin
- Reposted by Jonathan BohlenHuge variability documented in how publishers respond when informed about a problematic body of work by a research group. www.jclinepi.com/article/S089... #publishers #retractions
- Reposted by Jonathan BohlenA MUST-READ Review on Penetrance of Human Monogenic Inborn Errors (of Immunity, or not): Incomplete penetrance in inborn errors of immunity: A skeleton in the closet—The sequel url: rupress.org/jhi/article/...
- Reposted by Jonathan BohlenLatest by us! An mRNA-based broad-spectrum antiviral inspired by ISG15 deficiency protects against viral infections in vitro and in vivo | Science Translational Medicine www.science.org/doi/10.1126/...
- Excited to participate in this symposium!
- 1/ Join us on 24 Sept 2025 at the @institutimagine.bsky.social in Paris for the Novo Nordisk Prize Symposium: Inborn Errors of Immunity. Registration is free at: my.weezevent.com/novo-nordisk...
- Very nice review on genetic insights to B cell development: rupress.org/jhi/article/... by @alneehus.bsky.social and @bloodgenes.bsky.social
- Reposted by Jonathan Bohlen🥳Amazing publication from the Hornung lab, in collab. with the Carell lab, on the innate immune system: how modified RNA tricks the immune system. Big shout-out to the two first authors, Marleen Bérouti and Mirko Wagner! www.cell.com/cell/fulltex... @v-hornung.bsky.social @m-berouti.bsky.social
- Reposted by Jonathan Bohlen@nbellono.bsky.social and colleagues observed that Elysia sea slugs steal chloroplasts from algae and store them in specialized organelles called kleptosomes. During times of starvation, this allows them to photosynthesize in support of their energy needs! 🧪 www.cell.com/cell/abstrac...
- Reposted by Jonathan BohlenNo evidence for neutralizing IL1RN autoantibodies in our cohorts of MIS-C, SARS-CoV2 pneumonia or vaccine-induced myocarditis. onlinelibrary.wiley.com/doi/10.1111/... Great work by Anish Behere in Nils Landegren lab, Uppsala university
- We are looking for motivated Master Students who are interested to start an internship or thesis in the fall. The project will focus on molecular biology of mRNA translation and is a great opportunity to master some staple methods. Please get in touch @genecenter-lmu.bsky.social tinyurl.com/3f3kwmja
- Comprehensive and convincing report of a new IEI, with just a single patient! Congrats Stuart and the team. Stellar!
- 📢📢Published today in @jem.org 📢📢 New human inborn error of immunity. We describe the first reported human with a monogenic disorder caused by the disruption of ZBTB7B, which encodes the transcription factor ThPOK. rupress.org/jem/article/... @ubcmedicine.bsky.social @bcchresearch.bsky.social
- Wow, very cool and unexpected findings!
- Fascinating!
- New in @jem.org - Antunes et al. describe a pathogenic mutation in the deubiquitinase USP5 that is linked to congenital insensitivity to #pain. They show that mice with this mutation are hyposensitive to acute and chronic pain, and uncover the underlying mechanism. rupress.org/jem/article/...
- Reposted by Jonathan BohlenA PhD position is open in my group here in Heidelberg. We'll use cool primary cell models of osteosarcoma and genetic screens to understand and overcome mechanisms of clinically acquired drug resistance. It'll be a blast! karriere.klinikum.uni-heidelberg.de/index.php?ac...
- Excited to welcome Evan and exchange ideas!
- We're happy to welcome Evangelos Karousis next Monday! 🎉 He’ll be talking about “Decoding viral secrets using cell-free translation” 🧬 📅 May 12 🕐 1:15 PM ➡️Lynen Lecture Hall Don’t miss it! 🤗✨ @karousislab.bsky.social @jonathanbohlen.bsky.social @unibe.ch
- Reposted by Jonathan Bohlen1/ One of the most intriguing enigmas of the #COVID19 pandemic was the sudden and unprecedented outbreak of chilblains that accompanied the early waves of #SARSCoV2 infections. Our new study in @jem.org uncovers the underlying immunological mechanism rupress.org/jem/article/...
- Reposted by Jonathan BohlenRole of clonal inflammatory microglia in histiocytosis-associated neurodegeneration: Neuron www.cell.com/neuron/fullt...
