Jonas Verhellen
Theoretical physicist with a PhD in neuroscience. Postdoc in protein-protein interactions. Into art, science, and innovation.
Currently: Copenhagen 🇩🇰
Previously: Oslo 🇳🇴, London 🇬🇧, Brussels 🇧🇪
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- If you're near Copenhagen, I'd love to host you for a talk!
- Made it to @intconfchemstr.social.edu.nl.ap.brid.gy just in time for the Mike Lynch Award (after about 6 hours of public transport).
- #ICCS25 A Chemoinformatics Journey (in 17 parts) by Mike Lynch Awardee Val Gillet.
- #ICCS25 GENEOnet: Accurate Protein Binding Pocket Detection
- Big news! I've received a DKK 2.97 million postdoc grant from the Lundbeck Foundation to kick off my independent research at the University of Copenhagen! lundbeckfonden.com/news/young-t... #neuroscience #postdoc #LundbeckFoundation #mentalhealth
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- Thank you!
- I was very happy to discover Copenhagen has a statue for @janhjensen.bsky.social! 🦉🦉🦉
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- It was about time. 😉
- Come work with me! We are looking to bring on more top talent to our language modeling workstream at @ai2.bsky.social building the open ecosystem. We are hiring: * Research scientists * Senior research engineers * Post docs (Young investigators) * Pre docs job-boards.greenhouse.io/thealleninst...
- FYI @kl4sp.bsky.social :)
- Happy Valentine's day! And for all of us who need some extra love today - especially the NIH folks - here's a happy oxytocin molecule! 💞🧪
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- The day will come ... it always does. 💪
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- 😯 — 🙏
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- Ooh this looks nice! ✨ I was looking for something of this kind before the holidays. 😊
- I used to share this video on the other place every year at Christmas ... time for a new tradition. Happy holidays BlueSky! youtu.be/Etflv7R6NKA?...
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- I opened BlueSky during someone else's turn and your post was the first thing I saw. 😊🎄😂
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- Definitely worth considering. Also checking for repeats (different smiles somehow but same compound) and inconsistencies. There's quite a few issues with most of these (compiled) datatsets. I think Pat Walters has had a blog post about this. Can't remember exactly.
- 🔬 More #SciComm! 🔬 This week’s figure shows how severe mental disorders affect the entire body. 🧠 While these disorders are known for their impact on brain functioning (blue), patients are also disproportionately affected by physical diseases (red). Details 👇!
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View full threadCardiovascular diseases are one example. People with schizophrenia face a strikingly higher mortality risk compared to those without. This highlights the urgent need for integrated care that addresses both mental and physical health!
- Despite decades of research, people suffering from severe mental health disorders still face an average 10 to 15 year reduction in life expectancy. In part due to current medical limitations and in part due the severity of the comorbidities.
- Severe mental disorders, like schizophrenia and bipolar disorder, are linked to higher risks of diseases affecting organs across the body. For each disease cluster, I highlighted a representative organ and the 95% confidence interval mortality risk ratio compared to the general population.
- 🔬 Hello, BlueSky! Time for some more #SciComm! 🔬 Last week’s (procrastination 🙈) figure illustrates the frequency spectrum of genetic risk factors for Schizophrenia: common variants (blue), protein truncating variants (red), and copy number variations (green). More 👇!
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View full threadProtein-truncating variants, depicted in red, are rare mutations that disrupt the function of genes by prematurely shortening proteins. One such example is SETD1A, a methyltransferase, where mutations can interfere with transcription regulation, significantly increasing schizophrenia risk.
- Lastly, copy number variations (CNVs), marked in green, involve larger segments of DNA that are either duplicated or deleted. As seen with NRXN1, a gene essential for synaptic connectivity. Deletions of NRXN1 are strongly associated with schizophrenia.
- Common variants are frequent in the population, typically contribute modestly to risk, and are found by screening large populations. An example gene with common variations in schizophrenia is C4A which potentially plays a role in synaptic pruning, a critical brain development process.
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- Hello Klas!
- 🔬 Hello, BlueSky! Time for some #SciComm! 🔬 This week’s figure illustrates the onset and progression of schizophrenia, integrating symptom intensity (blue line), environmental and genetic risk factors (red boxes), and key disease milestones (white boxes) as they unfold across age.
- ✅ Importantly, a window of opportunity (green zone) represents the crucial timeframe for early detection and intervention, which could reshape long-term outcomes.
- This Figure is based on Figures 1.a and 1.b in the review paper "Altering the Course of Schizophrenia: Progress and Perspectives": www.nature.com/articles/nrd...
- I’m creating a Starter Pack for AI/ML in science. This includes people who create models, benchmarks, data resources, those with insightful views on the topic, and other relevant areas. If that’s you or someone you know, say hello below! 👇 👋
- 👋 I probably belong here too. [Generate joke about Bayesian prior].
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- You mean ... many pictures of excellent chocolate?
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- Cannot overstate how stellar of a job @amelierocks.bsky.social did the past three days! An absolute masterclass. Calm, composed, always human. 💯👏
- go.bsky.app/Qc4frbt Made a starter pack for computational chemists, let me know who I missed please @jchodera.bsky.social @olexandr.bsky.social @jelfschem.bsky.socialat://did:plc:no3avbdkex2mxmt4ulea5jyj/app.bsky.graph.starterpack/3laqzdsxhds2a
- Reporting for (interdisciplinary) duty 🫡.
- 🚀 Excited to announce that "Bayesian Illumination: Inference and Quality-Diversity Accelerate Generative Molecular Models" is now available! Key takeaway: Bayesian Illumination is 100x more effective than either genetic algorithms or deep generative models. 📊
- 📄 Preprint: doi.org/10.26434/che... 💻 GitHub: github.com/Jonas-Verhel... 📰 Docs: jonas-verhellen.github.io/Bayesian-Ill... Bayesian Illumination has been accepted at the ICML ML4LMS workshop! More updates to come!
- Over the summer, I wrote a blog post series based on my PHD thesis. ✍️ So, whether you are a fellow academic, a curious mind, or simply looking to expand your knowledge, check it out! I'll be republishing announcements here from time to time. ✨ Link: jonas-verhellen.github.io/blog-thesis-...
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- I really like the style of this plot. Wonder what it’s made in. 🤓
