Parul Johri
Population geneticist
Assistant Professor at UNC, Chapel Hill
- Reposted by Parul JohriPEQG! My favorite conference ever*. Single session, fantastic talks, great discussions. Only once every 2 years. And in the best conference location too! Abstract deadline coming up Feb 5! *Disclosure: I am required to say it's the best conference because it is and I told my mom I wouldn't lie.
- Reposted by Parul JohriThe last work of my PhD is finally out: www.pnas.org/doi/10.1073/...! This work is about accurately estimating branch length in the Ancestral Recombination Graph (ARG), which is achieved by a really simple framework with minimal assumptions. (1/n)
- Reposted by Parul JohriThe SMBE Graduate Student Excellence Award honors the best presentation at the Graduate Student Excellence symposium, which provides a forum for young investigators to showcase their exemplary research at the annual meeting. 📨 Award applications smbe2026.org/abstracts #SMBE2026
- We (with Fanny Pouyet and Brian Charlesworth) provide a theoretical perspective on rescaling forward simulations in population genetics, along with some guidelines: arxiv.org/abs/2601.05367
- Specifically, we discuss which population genetic quantities should be scaleable when employing diffusion theory-based rescaling approaches. We hope that this is useful when designing simulation projects.
- Reposted by Parul JohriI wrote a short op-ed in @genetics-gsa.bsky.social G3 this month’s issue on missing data problems in population genomics that I’ve been thinking about for a couple of years. Lemme know your thoughts! Comments/suggestions/ideas welcome! doi.org/10.1093/g3jo...
- We wrote a perspective piece about important considerations when building an evolutionary baseline model for population genomic inference in the deadliest malaria parasite- Plasmodium falciparum. www.biorxiv.org/content/10.6...
- This can be particularly challenging in pathogenic organisms due to their unique life cycles, complex demographic history with recurrent bottlenecks during transmission, strong selection against drugs, high-coding density across the genome, and skewed progeny distributions.
- Also fun to complete this as a group project in the lab with Cobi Henry, Jacob Marsh, @adaigle.bsky.social, and @james-crescenzi.bsky.social, along with Jessica Lin and Jeff Bailey.
- Reposted by Parul JohriA final new paper out from the lab, work from Steve Johnson, @joannarifkin.bsky.social & @stepheniwright.bsky.social We asked what maintains the striking variation in floral color, size, and shape within and among populations of Dame's Rocket, Hesperis matronalis
- Reposted by Parul JohriI'm on the Board of @biologists.bsky.social. Many know them as publishers of @dev-journal.bsky.social, @jcellsci.bsky.social, @jexpbiol.bsky.social , DMM, and @biologyopen.bsky.social --but they also are a major funder of small grants that empower young biologists and enable scientific meetings 🧪
- We believe that, as our future leaders in biology, it is vital to provide #ECRs with the right support during the early stages of your academic career. We offer a number of practical ways to help you meet the unique needs and challenges you may encounter: www.biologists.com/about-us/ear...
- Reposted by Parul JohriHappy to highlight an essay I wrote together with @marcdemanuel.bsky.social, @natanaels.bsky.social and Anastasia Stolyarova, trying to think through what sets the mutation rate of a cell type in an animal species: www.biorxiv.org/content/10.6... 1/n
- Now accepted in Genetics! academic.oup.com/genetics/adv... We ask why and when rescaling of forward simulations in population genetics is not accurate. There are some interesting results for people performing simulations with selection.
- Reposted by Parul JohriThe December episode of Genetics in Your World is now live!🎙️ ECS Multimedia Subcommittee member Debraj Manna interviewed Dr. Matthew Rockman (@wormsrock.bsky.social) of New York University about inbreeding depression in C. elegans. Listen now: buff.ly/7DVBt56
- Reposted by Parul Johri@lntran.bsky.social @castellanoed.bsky.social @ryangutenkunst.bsky.social introduce a systematic permutation approach for interpreting haplotype matrix-based methods in population genomics. 🔗 doi.org/10.1093/molbev/msaf250 #evobio #molbio
- The Johri Lab has an open postdoc position. Please send me an email, if interested. Start date is flexible. Please do share! Thank you in advance.
- Our latest preprint about the effects of rescaling forward-in-time simulations in population genetics - www.biorxiv.org/content/10.1...
- Recently, multiple studies have shown that rescaling forward simulations does not accurately capture the evolutionary dynamics of an unscaled population. However, some important questions remain unanswered –
- (a) When is rescaling reasonably accurate, and when does it break down? (b) Why does rescaling lead to the observed biases? (c) Can we realistically simulate whole genomes?
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View full threadBut, hitchhiking effects near functional regions are relatively unaffected by rescaling the population. Finally, we discuss how to accurately rescale simulations.
- Reposted by Parul JohriExcited to share my first PhD project with my mentor, @johriparul.bsky.social! We examine how Hill–Robertson interference (HRI) in highly selfing species biases estimates of the distribution of fitness effects of new mutations (DFE). doi.org/10.1093/evol... @journal-evo.bsky.social #popgen #evobio
